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In order to test this hypothesis, we have generated and behaviourally characterized GASP-1 knockout KO mice and have examined the consequences of the absence of GASP-1 on chronic cocaine treatments. Additional mice were trained to acquire intravenous self-administration of cocaine on a fixed ratio 1 schedule of reinforcement, and the motivational value of cocaine was then assessed using a progressive ratio schedule of reinforcement. The dopamine and muscarinic receptor densities were quantitatively evaluated in the striatum of WT and KO mice tested for sensitization and self-administration. Acute and sensitized cocaine-locomotor effects were attenuated in KO mice. A decrease in the percentage of animals that acquired cocaine self-administration was also observed in GASPdeficient mice, which was associated with pronounced down-regulation of dopamine and muscarinic receptors in the striatum. However, in contrast to previous studies, our data suggest that upon sustained receptor stimulation GASP-1 stimulates recycling rather than receptor degradation. Publication types Research Support, Non-U.

United States v. Maldonado, 23 F.3d 4 (1st Cir. 1994)

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Deputy Defense Minister Ivan Vega, who runs counterinsurgency efforts in the region, said that he was not aware of any military officials under investigation. Videos obtained by AP show small planes landing on clandestine air strips in the jungle region, about the size of Ireland. Elite squads of narcotics police hidden on nearby hilltops videotaped the landings, but were too outgunned to intervene, said two narcotics police officers who provided the videos but declined to speak on the record for fear of losing their jobs. Men with assault rifles guard the strip. Money is offloaded, drugs are jammed into the cabin. The motor re-engages. The plane departs. But critics say the government lacks the will to do the job, having inexplicably scrapped plans to buy and install the necessary state-of-the-art radar. When President Ollanta Humala took office in , he declared combatting illicit drugs a priority. His government has destroyed record amounts of coca leaf. In a July 28 independence day address four years after assuming office, the former army lieutenant colonel said trafficking in the valley had been reined in. Humala also points to more than missions to blast craters into the clandestine airstrips as a triumph. National police director Gen. Vicente Romero has said repeatedly that traffickers fill the holes in a matter of days using local labor. A special congressional committee in Peru was convened to probe drug corruption in politics after state and municipal elections last October in which Medina counted candidates either under investigation for or convicted of drug-related crimes. Its chairwoman, Rep. Police say they are just one of about 15 cocaine-producing syndicates operating here and are down to 60 fighters. But the government says if it destroyed coca plants in the valley, it would cause a backlash. But police rely on the military for airlifts and many chafe at having to go on joint drug missions with soldiers. One recalled asking about clandestine airstrips during a meeting with military officials. They had never informed us of all this. Four anti-drug prosecutors complained about it in a May letter to their boss that the AP obtained. Three times they shared information with the military on when and where drug flights would land, they said. In each case, the planes never showed. The fourth time, they kept the intelligence to themselves and acted alone with police. The March operation was the only one in the past two years in which drugs, money, plane and pilot were all taken into custody. Over that period, more than two dozen suspected drug planes have been seized. Most were crash-landings. In all but five cases, the pilots escaped. Before the narco-flight boom, the military sent people to the valley as punishment for transgressions, said Victor Andres Garcia Belaunde, an opposition congressman and nephew of the late President Fernando Belaunde. Modern radar coverage combined with aerial pursuit and on-the-ground interception can dramatically reduce drug flights — without shooting down planes, experience has shown in Colombia and Brazil. He watched in dismay from his King Air as the drug flights grew into an epidemic. He collected narco-plane tail numbers he recorded on intelligence missions — to little effect. It funds police academies, assists in money-laundering investigations, trains police and armed forces units and backs eradication and alternatives to coca. It does not, however, regularly fly surveillance aircraft over the country as it does for Colombia, the source of most of the cocaine consumed in the US. Now, all those choppers, based in the jungle city of Pucallpa, are only allowed to support coca eradication missions. It is destabilizing the country. Instead, the government decided to repair two vintage US-made TPS radars initially acquired in The first radar became operational in May. Peruvian counternarcotics police blast a hole in a clandestine airstrip used by cocaine traffickers in Ciudad Constitucion, Peru, in July

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