Making sperm from stem cells

Making sperm from stem cells
May 27, 2023
In vitro gametogenesis begins with "pluripotent stem cells", a kind of cell that can develop into many different cell types. The aim is to persuade these stem cells to become eggs or sperm.
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Spermatogenesis, the origin and development of sperm cells within the male reproductive organs, the testes. Sperm are produced specifically from stem cells in the walls of the seminiferous tubules. Learn about the processes of sperm cell production and maturation with this article.
Even artificial fertilization techniques depend on donors for both of these cells. However, a new study shows that mouse pluripotent stem cells can differentiate into functional sperm.
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Sperm (pl.: sperm or sperms) is the male reproductive cell, or gamete, in anisogamous forms of sexual reproduction (forms in which there is a larger, female reproductive cell and a smaller, male one). Sperm cells contribute approximately half of the nuclear genetic information to the diploid offspring (excluding, in most cases, mitochondrial DNA).
The sperm of plants that reproduce using spores are formed by mitosis in an organ of the gametophyte known as the antheridium and the egg cells by mitosis in a flask-shaped organ called the archegonium. [16] Plant sperm cells are their only motile cells, often described as flagellate, but more correctly as ciliate. [17]
For an organism to grow, cells must divide by mitosis producing two new identical cells. If cells are isolated at an early stage of growth before they have become too specialised, they can retain their ability to grow into a range of different types of cells. This phenomenon has led to the development of stem cell technology.
US researchers say they will redouble their efforts to create human sperm from stem cells following the success of a Japanese study involving mice.
An embryonic stem cell, which can morph into any other type of tissue, was guided towards becoming sperm with a cocktail of chemicals, hormones and testicular tissue.
In vitro gametogenesis — making eggs and sperm from stem cells — isn't yet ready for human parents, but we should start thinking and talking about the major ethical and legal questions it raises.
Researchers have developed a way to culture cells with the characteristics of human sperm stem cells.
The trick is working out how to encourage the stem cells to form egg or sperm cells.
The first and possibly most extensively studied option is the use of stem cells—undifferentiated cells with a differentiation potential that may possibly be directed to form gametes in general and specifically artificial sperm cells. 17 Another interesting direction to achieve ripe spermatozoa is to retrieve spermatids from the testes and to ...
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US researchers say they will redouble their efforts to create human sperm from stem cells following the success of a Japanese study involving mice.
Apr 4, 2025
Jan 26, 2025
A new study led by researchers at University of Utah Health tracing the development of human sperm stem cells to mature sperm cells has yielded the most comprehensive view of this process to date.
Sperm stem cells are normally found in the testes, where they divide to help provide a continuous supply of sperm. While sperm stem cells have two sets of chromosomes, mature sperm capable of ...
Researchers are starting a project to create an artificial human testicle from stem cells that can produce sperm.The researchers received a grant from the National Institutes of Health.
Researchers at Newcastle University in England report they have coaxed the first human sperm cells from embryonic stem cells, in a remarkable demonstration of how quickly the field of stem-cell ...
The present article focuses on male factor infer-tility. From the male partner perspective, fertiliza-tion cannot be achieved unless mature sperm cells are available. In cases of complete absence of any sperm cells from the ejaculate, surgical options exist for the retrieval of sperm cells from the testicles themselves or their adnexa.
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Embryonic stem cells from mice can spontaneously form the precursors of sperm in a culture dish, scientists report this week. When the immature cells are inserted back into mouse testes, they can develop into mature sperm.
Currently, there are both in vivo and in vitro model systems. In vivo model systems involve the transplantation of either spermatogonial stem cells or testicular xenographs. In vitro model systems involve the use of pluripotent stem cells and complex coculturing and/or three-dimensional culturing techniques.
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This is one of the reasons why making sperm and eggs from embryonic stem cells is so much more complicated than making the other specialised tissues of the body, such as heart muscle or brain ...
Scientists have discovered only a handful of genes responsible for stem cell self-renewal, a property that allows stem cells to continue giving rise to a variety of cell types during an organism ...
Researchers converted embryonic stem cells, which can become any type of tissue, into immature sperm cells called spermatids. These were injected into mouse eggs, which were fertilised successfully.
For an organism to grow, cells must divide by mitosis producing two new identical cells. If cells are isolated at an early stage of growth before they have become too specialised, they can retain their ability to grow into a range of different types of cells. This phenomenon has led to the development of stem cell technology.
Scientists have grown an entity that closely resembles an early human embryo, without using sperm, eggs or a womb. The Weizmann Institute team say their "embryo model", made using stem cells ...
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