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Lormetazepam tablets

Lormetazepam \\\\\\\\\\\\\\\\\[1\\\\\\\\\\\\\\\\\] INN , or methyl-lorazepam, marketed as Noctamid among others, is a drug which is a short to intermediate acting 3-hydroxy \\\\\\\\\\\\\\\\\[2\\\\\\\\\\\\\\\\\] benzodiazepine derivative. It possesses hypnotic , anxiolytic , anticonvulsant , sedative , and skeletal muscle relaxant properties. Lormetazepam is not approved for sale in the United States or Canada. It is licensed in the UK as 0. It is sold in Poland as Noctofer. The Dutch , British , and French system called the System of Objectified Judgement Analysis for assessing whether drugs should be included in drug formularies based on clinical efficacy, adverse effects , pharmacokinetic properties, toxicity , and drug interactions was used to assess lormetazepam. A Dutch analysis using the system found that lormetazepam could be suitable to be included in drug prescribing formularies, although zolpidem , zopiclone , and temazepam had higher scores and thus can be seen as relatively favorable. Lormetazepam is considered a hypnotic benzodiazepine and is officially indicated for moderate to severe insomnia. Lormetazepam is a short-acting benzodiazepine and is sometimes used in patients who have difficulty in maintaining sleep or falling asleep. Hypnotics should only be used on a short-term basis or, in those with chronic insomnia, on an occasional basis. Side effects of lormetazepam are similar to those of other hypnotic benzodiazepines and can for the most part be regarded as a class effect. Rebound effects have been reported after chronic use including rebound REM. For example, in a study comparing the amnesic effects of lormetazepam to temazepam and flurazepam showed that amnesia was smallest after lormetazepam and greatest after temazepam, which had produced greater amnesia than both lormetazepam and flurazepam by a significant margin. Residual 'hangover' effects after nighttime administration of lormetazepam such as sleepiness, impaired psychomotor and cognitive functions may persist into the next day which may impair the ability of users to drive safely and increase risks of falls and hip fractures. Benzodiazepines require special precaution if used during pregnancy, in children, in alcohol- or drug-dependent individuals and individuals with comorbid psychiatric disorders. The risks of tolerance, dependence, and withdrawal are very low when the drug is used for 2—4 weeks only, and lormetazepam is generally a safe and effective drug when used for no longer than 2—4 weeks. Some sleep disturbance in the form of rebound insomnia can, however, occur even after short-term usage of 7 days. Lormetazepam as with other benzodiazepines is generally only recommended for short-term use 2—4 weeks due to tolerance and loss of efficacy. Tolerance to and loss of the sedative effects of benzodiazepine hypnotics occurs within 14 days of regular use. Dependence is the medical term for addiction. Psychological dependence can manifest itself as a reliance on a drug to cope with everyday life or in the form of craving. Physical dependence occurs due to physiological adaptations occurring as the body attempts to overcome the drugs effects which is known as tolerance and the continuing need to take the drug to avoid or suppress withdrawal symptoms which can sometimes resemble the original condition being treated. When the dose or the drug is discontinued withdrawal symptoms typically occur. Lormetazepam as with all other benzodiazepines produces both physical and psychological dependence but the main problem of concern is physical dependence which appears in the form of the benzodiazepine withdrawal syndrome after the dosage is reduced or the drug is stopped completely. Withdrawal symptoms which can occur from stopping benzodiazepines such as lormetazepam can include: This is sometimes associated with dosage escalation. Lormetazepam has a short to intermediate half-life of approximately 10—12 hours. Shorter acting benzodiazepine compounds are generally associated with a more intense and immediate withdrawal reaction compared to longer acting benzodiazepines. For this reason it is generally recommended to cross from lormetazepam to an equivalent dose of diazepam to gradually taper the dosage. Lormetazepam and other benzodiazepine drugs act as positive modulators at the GABA A benzodiazepine receptor complex. Lormetazepam binds to the benzodiazepine receptor which in turn enhances the effect of the GABA A receptor producing its therapeutic effects as well as adverse effects. When lormetazepam binds to the benzodiazepine receptor sites in sufficient quantities it produces sedation which is used clinically as a therapeutic treatment for insomnia. Lormetazepam alters the brain electrical activity which has been studied via EEG readings. Lormetazepam contains a stereocenter and consists of two enantiomers. This is a racemate , ie a 1: From Wikipedia, the free encyclopedia. Acta Psychiatr Scand Suppl. Br J Clin Pharmacol. A randomized, cross-over, double-blind study versus placebo' PDF. Cloxazolam Flutazolam Haloxazolam Mexazolam Oxazolam. Glutethimide Methyprylon Pyrithyldione Piperidione. Serotonin antagonists and reuptake inhibitors Etoperidone Nefazodone Trazodone Tricyclic antidepressants Amitriptyline Doxepin Trimipramine , etc. Tetracyclic antidepressants Mianserin Mirtazapine , etc. Typical antipsychotics Chlorpromazine Thioridazine , etc. Atypical antipsychotics Olanzapine Quetiapine Risperidone , etc. Trazodone Tricyclic antidepressants Amitriptyline Doxepin Trimipramine , etc. Agomelatine Melatonin Ramelteon Tasimelteon. Gabapentin Gabapentin enacarbil Mirogabalin Phenibut Pregabalin. GABA A receptor positive modulators. Glutethimide Methyprylon Piperidione Pyrithyldione. Retrieved from ' https: Views Read Edit View history. In other projects Wikimedia Commons. This page was last edited on 13 September , at By using this site, you agree to the Terms of Use and Privacy Policy. R -lormetazepam CAS number: S -lormetazepam CAS number:

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