Легальный jwh
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Легальный jwh
JWH 1-pentyl 1-naphthoyl indole or AM \\\\\\\\\\\\[1\\\\\\\\\\\\] is an analgesic chemical from the naphthoylindole family that acts as a full agonist at both the CB 1 and CB 2 cannabinoid receptors, with some selectivity for CB 2. It produces effects in animals similar to those of tetrahydrocannabinol THC , a cannabinoid naturally present in cannabis, leading to its use in synthetic cannabis products that in some countries are sold legally as ' incense blends'. As a full agonist at both the CB 1 and CB 2 cannabinoid receptors, this chemical compound is classified as an analgesic medication. The analgesic effects of cannabinoid ligands, mediated by CB1 receptors are well established in treatment of neuropathic pain, as well as cancer pain and arthritis. As the cause is poorly understood in chronic pain states, more research and development must be done before we can realize the therapeutic potential of this class of biologic compounds. John W. Huffman , an organic chemist at Clemson University , synthesized a variety of chemical compounds that affect the endocannabinoid system. JWH is one of these compounds, with studies showing an affinity for the cannabinoid CB 1 receptor five times greater than that of THC. Cannabinoid receptors are found in mammalian brain and spleen tissue; however, the structural details of the active sites are currently unknown. On December 15, , it was reported by German pharmaceutical companies that JWH was found as one of the active components in at least three versions of the grey market drug Spice , which has been sold as an incense in a number of countries around the world since Urine was collected for 24 hours, followed by extraction of JWH metabolites using both liquid-liquid extraction and solid-phase extraction. GC-MS was utilized to separate and identify the extracted compounds. JWH and its N-dealkylated metabolite were only detected in small amounts, with hydroxylated N-dealkylated metabolites comprising the primary signal. The observed mass shift indicates that it is likely that hydroxylation occurs in both the naphthalene and indole portions of the molecule. At least one case of JWH dependence has been reported by the media. Withdrawal symptoms were more severe than those experienced as a result of cannabis dependence. JWH has been shown to cause profound changes in CB 1 receptor density following administration, causing desensitization to its effects more rapidly than related cannabinoids. Cannabinoid receptor full agonists may present serious dangers to the user when used to excess. Various physical and psychological adverse effects have been reported from JWH use. One study reported psychotic relapses and anxiety symptoms in well-treated patients with mental illness following JWH inhalation. JWH usage is readily detected in urine using 'spice' screening immunoassays from several manufacturers focused on both the parent drug and its omega-hydroxy and carboxyl metabolites. The major urinary metabolite is a compound that is monohydroxylated on the omega minus one carbon atom of the alkyl side chain. From Wikipedia, the free encyclopedia. IUPAC name. Retrieved Dtsch Arztebl Int. Drug and Alcohol Dependence. Archived from the original PDF on British Journal of Pharmacology. Archived from the original on Archived from the original on August 22, Forensic Science International. ACS Chemical Neuroscience. Retrieved September 8, The Journal of Neuroscience. Journal of Drug and Alcohol Dependence. Screening for the synthetic cannabinoid JWH and its major metabolites in human doping controls. Drug Test. Sep 24, Sensitive and rapid quantification of the cannabinoid receptor agonist naphthalenyl- 1-pentylindolyl methanone JWH in human serum by liquid chromatography-tandem mass spectrometry. J Chrom. B , Journal of Mass Spectrometry. Deutsches Arzteblatt International. Anal Bioanal Chem. Januar , S. Retrieved 17 May Archived from the original on 21 September Retrieved 18 July Retrieved 18 February Department of Anti-smuggling and Organised Crime. General Directorate of Legislation Development and Publication. The Times. Retrieved 11 March Natural Product Reports. WIN 55, Diphenidine Ephenidine Fluorolintane Methoxphenidine. Dextrallorphan Dextromethorphan Dextrorphan Racemethorphan Racemorphan. Apomorphine Aporphine Bromocriptine Cabergoline Lisuride Memantine Nuciferine Pergolide Phenethylamine Piribedil Pramipexole Ropinirole Rotigotine Salvinorin A Also indirect D 2 agonists, such as dopamine reuptake inhibitors cocaine , methylphenidate , releasing agents amphetamine , methamphetamine , and precursors levodopa. Glaucine Isoaminile Noscapine Pukateine. Cannabinoid receptor modulators. Agonists: Revosimeline. Namespaces Article Talk. Views Read Edit View history. In other projects Wikimedia Commons. By using this site, you agree to the Terms of Use and Privacy Policy. The Austrian Ministry of Health announced on 18 December that Spice would be controlled under Paragraph 78 of their drug law on the grounds that it contains an active substance that affects the functions of the body, and the legality of JWH is under review. JWH is claimed to be a controlled substance in Canada though it is not listed under schedule 2 synthetic cannabinoids. Health Canada is of the opinion that 'similar synthetic preparations' covers jwh though jwh is not similar in chemical structure nor in its action of the CB1 receptor. Note: the most current CDSA can be found here \\\\\\\\\\\\[34\\\\\\\\\\\\]. China has made JWH Illegal for sale. It is illegal to import or export JWH The Anti-narcotics department declared synthetic cannabinoids and their analogues illegal after an outbreak of JWH containing product referred to as 'Joker'. New Zealand. South Korea. The seizure of 2C-B in blue pill form on 13 October and the seizure of 0. Upon these reports the EWS committee initiated the regulation process by warning the Ministry of Health. The regulation is in effect since 13 February United Kingdom. United States.
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Легальный jwh
Синтезирование наркотика JWH
JWH 1-pentyl 1-naphthoyl indole or AM \\\\\\\\\\\\\\[1\\\\\\\\\\\\\\] is an analgesic chemical from the naphthoylindole family that acts as a full agonist at both the CB 1 and CB 2 cannabinoid receptors, with some selectivity for CB 2. It produces effects in animals similar to those of tetrahydrocannabinol THC , a cannabinoid naturally present in cannabis, leading to its use in synthetic cannabis products that in some countries are sold legally as ' incense blends'. As a full agonist at both the CB 1 and CB 2 cannabinoid receptors, this chemical compound is classified as an analgesic medication. The analgesic effects of cannabinoid ligands, mediated by CB1 receptors are well established in treatment of neuropathic pain, as well as cancer pain and arthritis. As the cause is poorly understood in chronic pain states, more research and development must be done before we can realize the therapeutic potential of this class of biologic compounds. John W. Huffman , an organic chemist at Clemson University , synthesized a variety of chemical compounds that affect the endocannabinoid system. JWH is one of these compounds, with studies showing an affinity for the cannabinoid CB 1 receptor five times greater than that of THC. Cannabinoid receptors are found in mammalian brain and spleen tissue; however, the structural details of the active sites are currently unknown. On December 15, , it was reported by German pharmaceutical companies that JWH was found as one of the active components in at least three versions of the grey market drug Spice , which has been sold as an incense in a number of countries around the world since Urine was collected for 24 hours, followed by extraction of JWH metabolites using both liquid-liquid extraction and solid-phase extraction. GC-MS was utilized to separate and identify the extracted compounds. JWH and its N-dealkylated metabolite were only detected in small amounts, with hydroxylated N-dealkylated metabolites comprising the primary signal. The observed mass shift indicates that it is likely that hydroxylation occurs in both the naphthalene and indole portions of the molecule. At least one case of JWH dependence has been reported by the media. Withdrawal symptoms were more severe than those experienced as a result of cannabis dependence. JWH has been shown to cause profound changes in CB 1 receptor density following administration, causing desensitization to its effects more rapidly than related cannabinoids. Cannabinoid receptor full agonists may present serious dangers to the user when used to excess. Various physical and psychological adverse effects have been reported from JWH use. One study reported psychotic relapses and anxiety symptoms in well-treated patients with mental illness following JWH inhalation. JWH usage is readily detected in urine using 'spice' screening immunoassays from several manufacturers focused on both the parent drug and its omega-hydroxy and carboxyl metabolites. The major urinary metabolite is a compound that is monohydroxylated on the omega minus one carbon atom of the alkyl side chain. From Wikipedia, the free encyclopedia. IUPAC name. Retrieved Dtsch Arztebl Int. Drug and Alcohol Dependence. Archived from the original PDF on British Journal of Pharmacology. Archived from the original on Archived from the original on August 22, Forensic Science International. ACS Chemical Neuroscience. Retrieved September 8, The Journal of Neuroscience. Journal of Drug and Alcohol Dependence. Screening for the synthetic cannabinoid JWH and its major metabolites in human doping controls. Drug Test. Sep 24, Sensitive and rapid quantification of the cannabinoid receptor agonist naphthalenyl- 1-pentylindolyl methanone JWH in human serum by liquid chromatography-tandem mass spectrometry. J Chrom. B , Journal of Mass Spectrometry. Deutsches Arzteblatt International. Anal Bioanal Chem. Januar , S. Retrieved 17 May Archived from the original on 21 September Retrieved 18 July Retrieved 18 February Department of Anti-smuggling and Organised Crime. General Directorate of Legislation Development and Publication. The Times. Retrieved 11 March Natural Product Reports. WIN 55, Diphenidine Ephenidine Fluorolintane Methoxphenidine. Dextrallorphan Dextromethorphan Dextrorphan Racemethorphan Racemorphan. Apomorphine Aporphine Bromocriptine Cabergoline Lisuride Memantine Nuciferine Pergolide Phenethylamine Piribedil Pramipexole Ropinirole Rotigotine Salvinorin A Also indirect D 2 agonists, such as dopamine reuptake inhibitors cocaine , methylphenidate , releasing agents amphetamine , methamphetamine , and precursors levodopa. Glaucine Isoaminile Noscapine Pukateine. Cannabinoid receptor modulators. Agonists: Revosimeline. Namespaces Article Talk. Views Read Edit View history. In other projects Wikimedia Commons. By using this site, you agree to the Terms of Use and Privacy Policy. The Austrian Ministry of Health announced on 18 December that Spice would be controlled under Paragraph 78 of their drug law on the grounds that it contains an active substance that affects the functions of the body, and the legality of JWH is under review. JWH is claimed to be a controlled substance in Canada though it is not listed under schedule 2 synthetic cannabinoids. Health Canada is of the opinion that 'similar synthetic preparations' covers jwh though jwh is not similar in chemical structure nor in its action of the CB1 receptor. Note: the most current CDSA can be found here \\\\\\\\\\\\\\[34\\\\\\\\\\\\\\]. China has made JWH Illegal for sale. It is illegal to import or export JWH The Anti-narcotics department declared synthetic cannabinoids and their analogues illegal after an outbreak of JWH containing product referred to as 'Joker'. New Zealand. South Korea. The seizure of 2C-B in blue pill form on 13 October and the seizure of 0. Upon these reports the EWS committee initiated the regulation process by warning the Ministry of Health. The regulation is in effect since 13 February United Kingdom. United States.
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