Le_Lea Pregnant

Le_Lea Pregnant
DUGGAR DIP Amy Duggar breaks all the family's modesty rules in sexy black swimsuit
KHLO WAY Kardashian fans rip Khloe for 'selfish' parenting decision days after son's birth
HORROR FIND Mystery as mom and son found dead stuffed in sofa a week after they vanished
LUCKY MOVES I won the $1.6B Powerball jackpot - My strategy to beat 1 in 292million odds
TEEN Mom Leah Messer responded to the pregnancy rumors floating around after fans claimed that they spotted a "baby bump" in recent pictures with boyfriend Jaylan Mobley.
Leah , 29, shared the "daily insights" from her pregnancy calendar in an Instagram Story.
In the snapshot, one of the categories stated: "Chance of getting pregnant."
The Teen Mom 2 star captioned the post: "Some of y'all's comments are disrespectful as f**k."
The MTV star said: "Shaking My Head" and added the SMH emoji.
Leah shares her twin girls, Ali and Aleeah, 12, with ex Corey Simms, to who she was married from 2010 to 2011.
She also shares her youngest child, Addie, with her ex Jeremy Calvert.
A Teen Mom Fan page shared the snap as fans flocked to the comments section.
Followers appeared to agree with Leah when she said was not pregnant after some had speculated that she was from her New Year's Eve pics.
🍼 Follow all our latest news & stories on Teen Mo m .
One said: "She didn’t look pregnant at all. People want everybody's stomach to be flat but theirs."
Another stated: "Let’s normalize us women get bloated from time to time. Stop searching when there’s nothing to be found."
While a third fan wrote: "Nothing about her looks pregnant. What is wrong with people?"
A commentator mentioned: "Leah looks amazing. People are just cruel."
Recently, Leah shared a sexy New Year’s Eve photoshoot with her boyfriend Jaylan.
In the series of snaps, Jaylan’s hand was on her thigh as she pushed him against the wall.
In another snap, Jaylan's hand rested on Leah's stomach as she wore a plunging V-necked dress and high slit up one leg.
Followers jumped onto the comments section because they claimed to have spotted a “bump” from her dress.
One follower asked: "Is she pregnant?" while another follower chimed in, “Looks like a baby bump.”
Back in September, the famous mom had been dealing with pregnancy rumors when she went public with her new love.
The TV star set the record straight and addressed those baby rumors on social media.
She shared a gif of a basketball player shaking his head to the tune of Mood 4 Eva by Beyoncé , Donald Glover, and JAY-Z .
The TV personality wrote in all caps: “PSA. I’m not pregnant just bloated!”
Do you have a story for The US Sun team?
Like us on Facebook at www.facebook.com/TheSunUS and follow us from our main Twitter account at @TheSunUS
Amy Duggar breaks all the family's modesty rules in sexy black swimsuit
Kardashian fans rip Khloe for 'selfish' parenting decision days after son's birth
VPR's Katie Maloney shows off in black swimsuit after Tom Schwartz split
Sister Wives fans SLAM Robyn Brown's treatment of the other wives in trailer
© 2020 THE SUN, US, INC. ALL RIGHTS RESERVED | TERMS OF USE | PRIVACY | YOUR AD CHOICES | SITEMAP

DUGGAR DIP Amy Duggar breaks all the family's modesty rules in sexy black swimsuit
KHLO WAY Kardashian fans rip Khloe for 'selfish' parenting decision days after son's birth
HORROR FIND Mystery as mom and son found dead stuffed in sofa a week after they vanished
LUCKY MOVES I won the $1.6B Powerball jackpot - My strategy to beat 1 in 292million odds
TEEN Mom Leah Messer responded to the pregnancy rumors floating around after fans claimed that they spotted a "baby bump" in recent pictures with boyfriend Jaylan Mobley.
Leah , 29, shared the "daily insights" from her pregnancy calendar in an Instagram Story.
In the snapshot, one of the categories stated: "Chance of getting pregnant."
The Teen Mom 2 star captioned the post: "Some of y'all's comments are disrespectful as f**k."
The MTV star said: "Shaking My Head" and added the SMH emoji.
Leah shares her twin girls, Ali and Aleeah, 12, with ex Corey Simms, to who she was married from 2010 to 2011.
She also shares her youngest child, Addie, with her ex Jeremy Calvert.
A Teen Mom Fan page shared the snap as fans flocked to the comments section.
Followers appeared to agree with Leah when she said was not pregnant after some had speculated that she was from her New Year's Eve pics.
🍼 Follow all our latest news & stories on Teen Mo m .
One said: "She didn’t look pregnant at all. People want everybody's stomach to be flat but theirs."
Another stated: "Let’s normalize us women get bloated from time to time. Stop searching when there’s nothing to be found."
While a third fan wrote: "Nothing about her looks pregnant. What is wrong with people?"
A commentator mentioned: "Leah looks amazing. People are just cruel."
Recently, Leah shared a sexy New Year’s Eve photoshoot with her boyfriend Jaylan.
In the series of snaps, Jaylan’s hand was on her thigh as she pushed him against the wall.
In another snap, Jaylan's hand rested on Leah's stomach as she wore a plunging V-necked dress and high slit up one leg.
Followers jumped onto the comments section because they claimed to have spotted a “bump” from her dress.
One follower asked: "Is she pregnant?" while another follower chimed in, “Looks like a baby bump.”
Back in September, the famous mom had been dealing with pregnancy rumors when she went public with her new love.
The TV star set the record straight and addressed those baby rumors on social media.
She shared a gif of a basketball player shaking his head to the tune of Mood 4 Eva by Beyoncé , Donald Glover, and JAY-Z .
The TV personality wrote in all caps: “PSA. I’m not pregnant just bloated!”
Do you have a story for The US Sun team?
Like us on Facebook at www.facebook.com/TheSunUS and follow us from our main Twitter account at @TheSunUS
Amy Duggar breaks all the family's modesty rules in sexy black swimsuit
Kardashian fans rip Khloe for 'selfish' parenting decision days after son's birth
VPR's Katie Maloney shows off in black swimsuit after Tom Schwartz split
Sister Wives fans SLAM Robyn Brown's treatment of the other wives in trailer
© 2020 THE SUN, US, INC. ALL RIGHTS RESERVED | TERMS OF USE | PRIVACY | YOUR AD CHOICES | SITEMAP

From Wikipedia, the free encyclopedia

^ GRUBB R (1948). "Correlation between Lewis blood group and secretor character in man". Nature . 162 (4128): 933. Bibcode : 1948Natur.162..933G . doi : 10.1038/162933a0 . PMID 18104581 . S2CID 4104311 .

^ Jump up to: a b c d e f g h Mais DD. ASCP Quick Compendium of Clinical Pathology, 2nd Ed. Bethesda: ASCP Press, 2008.

^ Marionneau, S.; Cailleau-Thomas, A.; Rocher, J.; Le Moullac-Vaidye, B.; Ruvoën, N.; Clément, M.; Le Pendu, J. (2001). "ABH and Lewis histo-blood group antigens, a model for the meaning of oligosaccharide diversity in the face of a changing world". Biochimie . 83 (7): 565–73. doi : 10.1016/s0300-9084(01)01321-9 . PMID 11522384 .

^ Holgersson, J.; Breimer, M. E.; Samuelsson, B. E. (1992). "Basic biochemistry of cell surface carbohydrates and aspects of the tissue distribution of histo-blood group ABH and related glycosphingolipids". APMIS. Supplementum . 27 : 18–27. PMID 1520526 .

^ Jump up to: a b Issitt PD, Anstee DJ. Applied Blood Group Serology. 4th Ed. Durham, NC: Montgomery Scientific Publications, 1998.

^ Harmening, [edited by] Denise M. (2005). Modern blood banking and transfusion practices (5th ed.). Philadelphia: F.A. Davis. ISBN 978-0-8036-1248-8 . {{ cite book }} : |first= has generic name ( help )

^ Jump up to: a b c d e f g h i j k Roback JD et al. AABB Technical Manual, 16th Ed. Bethesda: AABB Press, 2008.

^ Boren, T.; Falk, P.; Roth, K. A.; Larson, G.; Normark, S. (1993). "Attachment of Helicobacter pylori to human gastric epithelium mediated by blood group antigens". Science . 262 (5141): 1892–5. Bibcode : 1993Sci...262.1892B . doi : 10.1126/science.8018146 . PMID 8018146 .

^ Franchini, M.; Veneri, D. (2004). "Helicobacter pylori infection and immune thrombocytopenic purpura: An update". Helicobacter . 9 (4): 342–6. doi : 10.1111/j.1083-4389.2004.00238.x . PMID 15270749 . S2CID 36822965 .

^ Hutson, A. M.; Atmar, R. L.; Marcus, D. M.; Estes, M. K. (2003). "Norwalk virus-like particle hemagglutination by binding to h histo-blood group antigens" . Journal of Virology . 77 (1): 405–15. doi : 10.1128/jvi.77.1.405-415.2003 . PMC 140602 . PMID 12477845 .

^ Hilton, E.; Chandrasekaran, V.; Rindos, P.; Isenberg, H. D. (1995). "Association of recurrent candidal vaginitis with inheritance of Lewis blood group antigens". The Journal of Infectious Diseases . 172 (6): 1616–9. doi : 10.1093/infdis/172.6.1616 . PMID 7594730 .

^ Stapleton, A.; Nudelman, E.; Clausen, H.; Hakomori, S.; Stamm, W. E. (1992). "Binding of uropathogenic Escherichia coli R45 to glycolipids extracted from vaginal epithelial cells is dependent on histo-blood group secretor status" . The Journal of Clinical Investigation . 90 (3): 965–72. doi : 10.1172/JCI115973 . PMC 329952 . PMID 1522244 .

^ Ducreux, M.; Cuhna, A. Sa.; Caramella, C.; Hollebecque, A.; Burtin, P.; Goéré, D.; Seufferlein, T.; Haustermans, K.; Van Laethem, J.L.; Conroy, T.; Arnold, D. (September 2015). "Cancer of the pancreas: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up" . Annals of Oncology . 26 : v56–v68. doi : 10.1093/annonc/mdv295 . PMID 26314780 .

The Lewis antigen system is a human blood group system . It is based upon two genes on chromosome 19 : FUT3 , or Lewis gene; and FUT2 , or Secretor gene. Both genes are expressed in glandular epithelia. FUT2 has a dominant allele which codes for an enzym (designated Se) and a recessive allele which does not produce a functional enzyme (designated se). Similarly, FUT3 has a functional dominant allele (Le) and a non-functional recessive allele (le).

The proteins produced by the FUT2 and FUT3 genes modify type I oligosaccharide chains to create Lewis antigens. These oligosaccharide chains are similar to the type II chains of the ABO blood system , with a single bond in a different position. The link between the Lewis blood group and secretion of the ABO blood group antigens was possibly the first example of multiple effects of a human gene : [1] the same enzyme (fucosyltransferase2) which converts the Le-a antigen to Le-b is also responsible for the presence of soluble A, B and H antigens in bodily fluids.

There are two main types of Lewis antigens, Lewis a (Le-a) and Lewis b (Le-b). There are three common phenotypes: Le(a+b-), Le(a-b+), and Le(a-b-). [2]

The enzyme fucosyltransferase 3 (FUT3), encoded by Le gene, adds a fucose to the precursor oligosaccharide substrate, converting it to the Le-a antigen. People who have the Le allele and who are non-secretors (homozygous for the nonfunctional se allele) will express the Le-a antigen in their bodily fluids and on their erythrocytes.

If a person has both the Le and Se alleles, their exocrine cells will also have the enzyme fucosyltransferase 2 (FUT2). This adds fucose to the oligosaccharide precursor in a different position from the FUT3 enzyme. This produces the Le-b antigen. In most people having both Le and Se, it is difficult to detect the antigen Le-a. This is because the activity of the FUT2 enzyme is more efficient than the FUT3 enzyme, so the type I oligosaccharide chain is mostly converted into Le-b instead of Le-a. Therefore, people with readily detectable Lewis-a antigen are non-secretors; they do not have FUT2 activity. Lewis-b antigen is found only in secretors: people who possess the Se allele and thus have FUT2 activity. Lewis negative people (Le a-, Le b-) are homozygous for the recessive le allele and can be either secretors or non-secretors.

Lewis antigens are expressed on the surface of red blood cells , endothelium , kidney, genitourinary and gastrointestinal epithelium . [3] [4] [5] Lewis antigens are red blood cell antigens which are not produced by the cell itself. Instead, Lewis antigens are components of exocrine epithelial secretions, and are subsequently adsorbed onto the surface of the red cell. [6]

The three above-stated common Lewis phenotypes represent the presence or absence of Lewis and Secretor enzymes. [ citation needed ]

Le(a+b-) individuals have at least one functional Lewis gene (Le) but are homozygous for nonfunctional Secretor alleles (sese). Thus, these individuals synthesize and secrete Le(a) antigen but lack Le(b) and type 1 chain ABH. [7]
Le(a-b+) individuals inherit both Le and Se alleles, leading to the synthesis of Le(a), Le(b), and type 1 chain ABH. Most type 1 chain precursor is converted to Le(b), therefore these individuals appear as if they are Le(a-). [7]
Le(a+b+) phenotype is transiently observed in infants (Secretor activity increases with age). [7] This phenotype is also encountered in 16% of Japanese individuals (who inherit a weak Secretor gene- Se(w)).

In absence of a functional Lewis gene (lele), neither Le(a) nor Le(b) are synthesized, leading to the Le(a-b-) phenotype. This phenotype is more common in persons of African descent. [7]

Two precursor oligosaccharides exist, type 1 and type 2. Type 1 is found in secretions and in the serum. Type 2 is found exclusively on the surface of red blood cells. No type 1 oligosaccharide is found on RBCs. Unbranched type 1 and 2 oligosaccharides represent i antigen . Branched type 1 and 2 oligosaccharides are I antigens . [2]

In neonates, i antigen oligosaccharides predominate (high in cord blood samples). Oligosaccharide branching increases with age, thus adults have mostly I antigen . [2]

The H gene of the ABO system encodes a fucosyltransferase that adds fucose to type 2 precursor substances on the surface of RBCs to make H antigen. The h allele is an amorphic form of the gene. If no further modifications are made to the H antigen, the person is type O. When the A gene product acts on the H antigen and adds an N-acetylgalactosamine, the A antigen results and the person is type A. When the B gene product acts on the H antigen to add a galactose, the B antigen results and the person is type B. [2]

The Le gene encodes a fucosyltransferase that adds fucose to type 1 precursor substance (both free in serum and in secretions) to make the Le(a) antigen. The le gene is an amorph. The Lewis antigen produced on free type 1 precursor substance passively adsorbs onto the surfaces or red blood cells. [2]

The Se gene encodes a fucosyltransferase that adds fucose to type 1 precursor generating H antigen. After this step, the Le gene product (FUT3) can add another fucose producing Le(b) antigen. Thus, individuals with the Le gene but no Se gene will have red blood cells bearing only the passively-adsorbed Le(a) but no Le(b). Individuals with both the Le gene and the Se gene will have red blood cells bearing only the passively adsorbed Le(b) and no Le(a). Individuals with no Le gene have neither Le(a) nor Le(b). [2]

In addition, the Se gene product is responsible for the presence of A, B and H substances in secretions. [ citation needed ]

Lewis antibodies are naturally occurring antibodies, almost always IgM type, found almost exclusively in Le(a-b-) individuals. [7] Lewis antibodies may include a mixture of anti-Le(a), anti-Le(b) and anti-Le(a+). [7]

Lewis antibodies are almost always clinically insignificant because:

Therefore, it is not necessary to transfuse antigen-negative blood components for most patients.

Lewis antibodies are generally reactive at room temperature and only occasionally at 37 C and AHG phase (antihuman globulin).

Lewis antibodies are not a cause of hemolytic disease of the fetus and newborn (HDFN), as stated below.

Lewis antigens cannot be reliably detected until the 2nd birthday. Lewis antibodies in a pregnant woman are essentially totally insignificant because they are IgM subtype (don't cross the placenta) and Lewis antigen is weakly expressed during pregnancy (Lewis Le(a-b-) phenotype is commonly seen during gestation). [2] Most newborns will type as Le(a-b-). [7]

Lewis antigen is often decreased on RBCs during pregnancy with some women transiently typing as Le(a-b-). [7] This is thought to be due in part to increased circulating plasma volume in pregnancy and increased lipoprotein. [5]

The Le(b) and H antigens are receptors for the bacteria Helicobacter pylori , a gram-negative bacterium that can cause gastritis and has been implicated in peptic ulcer disease , gastric adenocarcinoma , mucosa-associated lymphoma (or mucosal associated lymphatic tissue lymphoma – MALToma) and idiopathic thrombocytopenic purpura (ITP). [7] [8] [9]

Le(b) and type 1 H antigens are also receptors for Norwalk virus (common cause of acute gastroenteritis). [10]

The Le(a-b-) phenotype is associated with an increased susceptibility to infections by Candida and uropathogenic Escherichia coli . [7] [11] [12]

In patients with pancreatic adenocarcinoma and not harbouring a functional Lewis enzyme (Lea-b- genotype: 7%–10% of the population), levels of CA 19-9 are typically undetectable or below 1.0 U/ml. [13]

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