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WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section. It is not a recommendation and should be verified with other sources for accuracy. It acts as a norepinephrine-dopamine reuptake inhibitor. Reports of its use began to appear in the early s. Commonly reported effects include stimulation , disinhibition , increased libido , compulsive redosing , and euphoria. Very little data exists about the pharmacological properties, metabolism, and toxicity of a-PVP. Due to its potent psychostimulant effects and unknown toxicity profile, it is highly advised to use harm reduction practices if using with this substance. Substituted cathinones are derivatives of the naturally occurring substance cathinone , which is one of the psychoactive principles in khat Catha edullis. Cathinone is composed of a phenethylamine core with an alkyl group attached to the alpha carbon, and a ketone group attached to the beta carbon. Disclaimer: The effects listed below are cited from the Subjective Effect Index SEI , which relies on assorted anecdotal reports and the personal experiences of PsychonautWiki contributors. As a result, they should be taken with a healthy amount of skepticism. Likewise, adverse effects become much more likely on higher doses and may include serious injury or death. There are currently no anecdotal reports which describe the effects of this compound within our experience index. Additional experience reports can be found here:. Anecdotal reports suggest that there do not seem to be any negative health effects attributed to simply trying this substance at low to moderate doses by itself and using it sparingly but nothing can be guaranteed. It is strongly recommended that one use harm reduction practices when using this substance. When addiction has developed, cravings and withdrawal effects may occur if a person suddenly stops their usage. This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about 3 - 7 days for the tolerance to be reduced to half and 1 - 2 weeks to be back at baseline in the absence of further consumption. Although many psychoactive substances are reasonably safe to use on their own, they can quickly become dangerous or even life-threatening when combined with other substances. The list below includes some known dangerous combinations although it cannot be guaranteed to include all of them. Independent research e. Google , DuckDuckGo should always be conducted to ensure that a combination of two or more substances is safe to consume. Some interactions listed have been sourced from TripSit. Combinations with the following substances can cause dangerously high serotonin levels. Serotonin syndrome requires immediate medical attention and can be fatal if left untreated. Not to be confused with A-PHP. Physical effects. Visual effects. Cognitive effects. Auditory effects. After effects. Main article: Stimulant psychosis. Retrieved December 25, Treatment for amphetamine psychosis. The Cochrane Library. New York: Oxford University Press. ISBN Dose-independent occurrence of seizure with tramadol. Journal of Medical Toxicology, 5 2 , Monoamine oxidase inhibitors, opioid analgesics and serotonin toxicity. British Journal of Anaesthesia, 95 4 , Retrieved December 18, Bundesanzeiger Verlag. Misuse of Drugs Act S. London: The Stationery Office Limited. Navigation menu Personal tools Create account Log in. Namespaces Page Discussion. Views Read View source View history. Community Network YouTube Good vibes.

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