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When under the influence of this drug, the user feels neither fatigue nor thirst and becomes unresponsive to the alarm bells sent by the body. Anxiety and insomnia Back ache, muscle pain and tension Confusion Defensive attitude Dehydration Depressive state when coming down from the high Dilated pupils Disorientation Dry mouth Exhaustion Flushing and excessive sweating Headache Impulsivity Increased heart rate Irrational behaviour Jaw tension Loss of appetite Loss of motivation Mental fatigue Motor tics, gait disturbance Nystagmus involuntary, jerky eye movements and blurred vision Obsessive behaviour Sexual dysfunction: erectile dysfunction; may prevent women from reaching orgasm Tachycardia increased heart rate Teeth grinding Trismus masticatory muscle spasm Urinary retention or urgent need to urinate. Tolerance to MDMA appears to develop quickly. That said, with repeated use, it becomes difficult, if not impossible for users to experience the same effects they did when they first started. Although some users become dependent, very few cases of MDMA-specific dependence have been reported in the literature. Since most users take this drug only occasionally, dependence is not very prominent. Withdrawal symptoms are caused by a depletion of serotonin and may include depression and anxiety. Other symptoms associated with withdrawal are insomnia, panic attacks, agitation, psychosis and paranoid delusions. During withdrawal, users may also experience fatigue, sadness, bad moods and nightmares. Many different street drugs are sold under the same name. Furthermore, nothing guarantees the quantity, purity or even the content of a street drug in spite of the fact that it may, in some cases, look like medication. This content is for information purposes only and does not in any manner whatsoever replace the opinion or advice of your health care professional. Always consult a health care professional before making a decision about your medication or treatment. The emotional and pro social effects of MDMA are likely caused by the release of large amounts of serotonin. Serotonin then triggers the release of the hormones ocytocin and vasopressin, which play an important role in love, trust, sexual arousal and other social experiences. This may explain the feeling of empathy and the increased need for intimacy associated with this drug. Routes of administration Ingested the most common route , smoked, injected or snorted. Effects sought out by the user Desire to communicate with others Distorted perception of time Euphoria Extraversion Heightened sensuality and increased need for intimacy Heightening and distortion of sensory and enjoyment perceptions Intensification of emotions Lowered inhibitions Reduced fatigue Self-confidence Spontaneity Common toxic effects When under the influence of this drug, the user feels neither fatigue nor thirst and becomes unresponsive to the alarm bells sent by the body. Addiction Although some users become dependent, very few cases of MDMA-specific dependence have been reported in the literature. Withdrawal Withdrawal symptoms are caused by a depletion of serotonin and may include depression and anxiety. Onset and duration of action Route of administration Onset of action Peak Duration of action Ingested about 20 to 70 minutes about 2 hours about 4 to 6 hours Intoxication management No antidote available. Treatment is mainly symptomatic. If you need help or want to learn more: Partnership for a Drug-Free Canada. Share This Article. Find a Pharmacy. Newsletter Signup. Expect up-to-date health and lifestyle advice, special promotions, and more! Blocks the reuptake and promotes the release of serotonin, dopamine and noradrenaline.

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