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The use of illicit substances continues to pose a substantial threat to global health, affecting millions of individuals annually. Dysbiosis of the GM has been associated with the pathogenesis of various chronic diseases, including metabolic, malignant, and inflammatory conditions. However, little is currently known about the involvement of this axis in modulating the GM in response to psychoactive substances. In this study, we investigated the effect of MDMA 3,4-methylenedioxymethamphetamine, 'Ecstasy' -dependence on the behavioral and biochemical responses, and the diversity and abundance of the gut microbiome in rats post-treated or not with aqueous extract of Anacyclus pyrethrum AEAP , which has been reported to exhibit anticonvulsant activity. The dependency was validated using the conditioned place preference CPP paradigm, behavioral, and biochemical tests, while the gut microbiota was identified using matrix-assisted laser desorption ionization-time of flight mass spectrometry MALDI-TOF MS. These findings suggest that A. Abstract The use of illicit substances continues to pose a substantial threat to global health, affecting millions of individuals annually. Substances N-Methyl-3,4-methylenedioxyamphetamine. Grants and funding.

Мефедрон Лейден Нидерланды