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By using our site, you agree to our collection of information through the use of cookies. To learn more, view our Privacy Policy. To browse Academia. Oxidative stress directly correlates to the development and clinical course of severe acute surgical pathology, increasing its mortality, particularly in acute diffuse peritonitis ADP , acute intestinal obstruction AIO with acute pancreatitis AP. Luis Sabater. Milan Kaska. This clinical study compared the dynamics of antioxidants levels in patients with acute pancreatitis AP , patients operated for colorectal cancer CA , and healthy control subjects. This prospective descriptive study enrolled 21 AP and 14 CA patients and 17 healthy controls. Blood was collected from AP patients on days 1, 5, and 9 and from CA patients before surgery and on days 1, 5, and 9 after surgery. Low levels of measured antioxidants and increased activity of reactive oxygen species occurred during the course of AP. These findings applied in particular to patients who had severe AP. Levels of measured antioxidants seemed to be similar in AP and CA patients except for lower levels of selenium in toe nails in AP patients and lower selenium concentrations in RBCs in patients with severe AP. Fermin Pacheco. David Bar-Or. Postoperative complications are still a major concern after liver resection LR. Systemic inflammation and deregulated reactive oxygen species during major abdominal surgery may impair outcome after hepatectomy. Furthermore, Th1- and Th2-specific cytokines were assessed. Jorge Peralta. Conclusions Production of excited oxygen species is earlier in the liver than in the pancreas and could contribute to damage in a reflux model. Unexpectedly, it was found an increased plasma antioxidant capacity that was related to total bilirubin levels, and declined at late stages probably denoting other circulating antioxidant consumption. Background Oxidative stress has been shown to play a role in different models of acute pancreatitis, although it has not been studied in the severe necrohemorrhagic model produced by closed duodenal loop pancreatitis. Methods We studied Sprague Dawley female rats in two groups: a closed duodenal loop pancreatitis group and a control, sham-operated group. In order to evidence the oxygen excited species production,in situ spontaneous chemiluminescence from living and naturally perfused pancreas and liver was measured at 0, 0. Blood pancreatic amylase and aminotransferases levels were determined as expression of tissue damage in pancreas and liver. At the same time, plasma antioxidant capacity was measured by the peroxyl radical trapping capability of plasma samples compared to that of Trolox synthetic analog of vitamin E , and results are expressed as Trolox equivalence. Bovine superoxide dismutase SOD was administered to attenuate oxygen free radicals activity at the beginning of the peroxidation chain and also as a therapeutic tool. Results The experimental procedure induced a severe pancreatitis, as evidenced by pancreatic enzymes that rose markedly in the early hours of disease and remained heightened throughout the experiment. The results show early light emission from the liver at 3 h and peak levels at 12 h, whereas in the pancreas, luminescence increased at 6 h and doubled later at 12 h, both returning to control levels at 24 h. Javier Escobar. Holley Vasquez. Ruth Condray. Log in with Facebook Log in with Google. Remember me on this computer. Need an account? Click here to sign up. Download Free PDF. Marta Gerasymchuk. Related Papers. Current medicinal … Interaction between cytokines and oxidative stress in acute pancreatitis. Nutrition Dynamics of antioxidants in patients with acute pancreatitis and in patients operated for colorectal cancer: A clinical study. Serum oxidative stress is increased in patients with post cholecystectomy bile duct injury. PloS one Inflammatory response and oxidative stress during liver resection. International Journal of Gastrointestinal Cancer Oxidative stress in rodent closed duodenal loop pancreatitis. Biochemical Pharmacology Oxidative and nitrosative stress in acute pancreatitis. Modulation by pentoxifylline and oxypurinol. The British journal of psychiatry. Supplement Vulnerability to relapse in schizophrenia.

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