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This advice applies if you are determined to take MDMA. If finger dipping powder: Low doses may be particularly important for your first few uses, as you might unknowingly have a health condition like malignant hyperthermia that makes MDMA more dangerous. A study found that MDMA desirable effects are maximized, and undesirable effects minimized, at doses between mg. This dosage advice is only relevant if you actually have MDMA! Fake MDMA substances like methylone have weaker effects per milligram. Look up your pill and see if you can figure out the dosage content. The best dosage of pure MDMA based on our current knowledge for maximum desirable effects, minimum undesirable effects, and safer use, is: RollSafe knows that many people will choose not to follow this dosage advice. Lower dosages help reduce neurotoxicity risk, help increase enjoyment, and help reduce the risk of serious adverse effects. I think MDMA may well be neurotoxic at the higher end of recreational doses. Studies by MAPS have looked for changes in mental abilities after people participated in their studies, with some participants receiving mg followed by As a result, I tend to think 1. So I would personally suggest 1. Interestingly, MAPS is seeing preliminary evidence that lower doses might be more therapeutic, which is consistent with observations by therapist Leo Zeff that people want higher doses than they need. From the fantastic book Acid Test. That point came at 2. Eight doses of that size were administered over four months one dose every two weeks , after which there was no detectable damage to neurons. Rick was greatly relieved, since that would be the key to persuading the FDA that it would be safe enough to conduct human therapeutic trials. I would be unsurprised if many of the MDMA-related deaths occur in people with contraindicated health conditions, i. Though it is important to note that some people may have a contraindicated condition and not realize it. How do you know? Higher doses are more likely to cause neurotoxicity. Higher doses are more likely to lead to serious adverse effects, including the possibility of MDMA-related death. We have not heard of any deaths related to taking pure MDMA at a dosage of less than mg. RollSafe does not support the Erowid dosage advice - it is too high for users that care about their health. Avoid taking any booster doses or redoses if possible. Your MDMA may not be pure, and you may be increasing your risk as a result. Read more on testing. Always re-set your dosage with a new source. Desirable effects are maximized between mg A study found that MDMA desirable effects are maximized, and undesirable effects minimized, at doses between mg. Really, everyone should buy a test kit. Higher doses are less safe Higher doses are more likely to cause neurotoxicity. Buy a 1 mg scale. Use a spoon or similar to put little bits of MDMA onto the playing card, until it reaches your safe dosage. Put the folded edge of the card up to the capsule, and tap it until the MDMA is inside the capsule. This is why it helps if it is folded. Results from an online testing service \\\\\\\\\\\\\[return\\\\\\\\\\\\\] http: