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Cocaine is a powerful recreational drug that has a wide range of physical and psychoactive effects including intense feelings of euphoria, happiness , and alertness. Cocaine has gained infamy over the years due to its association with popular culture and celebrity use and abuse. Cocaine continues to be a controversial drug due to its powerful effects on the body, its contentious history, and its addictive nature. Read on to discover some unlikely health benefits and learn more about the dangerous effects of cocaine. Selfhacked does not support the use of cocaine, even though it may have some benefits. We feel the negatives far outweigh any of the positives. Cocaine benzoylmethylecgonine is a well-known illegal stimulant that is widely used all over the world \\\\\\\\\\\\\[ R , R \\\\\\\\\\\\\]. In spite of its recent notoriety, cocaine has a documented history of use by the Amara Indians of Peru. This low-level usage appears to have produced few adverse effects, presumably due to the low concentration of the active component in the leaves and the laborious act of extracting cocaine by chewing the coca leaves \\\\\\\\\\\\\[ R \\\\\\\\\\\\\]. However, its use changed after when the German chemist Albert Niemann purified cocaine \\\\\\\\\\\\\[ R \\\\\\\\\\\\\]. Around the end of , cocaine started gaining publicity due to the interest conveyed by a number of scientists. Sigmund Freud praised the drug in his famous Cocaine Papers describing its therapeutic properties in relieving depression and anxiety \\\\\\\\\\\\\[ R \\\\\\\\\\\\\]. Purified cocaine became commercially available when Merck started refining and producing it \\\\\\\\\\\\\[ R \\\\\\\\\\\\\]. Without regulatory restrictions, cocaine was initially sold as both a therapeutic and consumable product \\\\\\\\\\\\\[ R \\\\\\\\\\\\\]. However, the passage of the Harrison Narcotics Act of in the US banned the distribution of cocaine due to widespread cocaine abuse and addiction \\\\\\\\\\\\\[ R \\\\\\\\\\\\\]. Despite regulatory restrictions, the drug is still sold and used illegally around the world. According to a United Nations report, around Cocaine is a white crystal powder that can be snorted, smoked, or injected \\\\\\\\\\\\\[ R \\\\\\\\\\\\\]. Its street names include coke, flake, snow, and powder. More specifically, cocaine blocks the dopamine transporter SLC6A3 , which causes a buildup of dopamine and an overactivation of dopamine receiving neurons \\\\\\\\\\\\\[ R \\\\\\\\\\\\\]. Also, by blocking neurotransmitter transporters through a similar mechanism, cocaine increases norepinephrine and serotonin , which has a profound effect on both the brain and the heart \\\\\\\\\\\\\[ R , R \\\\\\\\\\\\\]. The release of dopamine in the brain causes psychoactive changes as increased body movements and mood \\\\\\\\\\\\\[ R \\\\\\\\\\\\\]. As shown by animal studies involving cocaine, endothelin-1 plays a major role in narrowing the blood vessels vasoconstriction in the brain cerebrum \\\\\\\\\\\\\[ R \\\\\\\\\\\\\]. Cocaine binds to the following dopamine, serotonin, and norepinephrine transporters and blocks the transport of these neurotransmitters back into the presynaptic terminals enhancing their effects:. Cocaine exerts its adverse effects at both cellular and molecular levels. Mitochondria are the energy generators of the cell. As shown by cell-based studies, cocaine can accumulate inside the cell and damage the functional and structural integrity of mitochondria disrupting cellular energy production and resulting in cell death \\\\\\\\\\\\\[ R \\\\\\\\\\\\\]. Also, animal studies showed that cocaine could produce oxidative stress in cells and alter mitochondrial gene products \\\\\\\\\\\\\[ R \\\\\\\\\\\\\]. In the heart, this oxidative stress leads to toxicity and cell death, as observed in human cocaine overdose \\\\\\\\\\\\\[ R \\\\\\\\\\\\\]. Cocaine users have reported a wide range of adverse psychological effects including anxiety, depression , mood swings, paranoia, and panic attacks \\\\\\\\\\\\\[ R \\\\\\\\\\\\\]. Chronic cocaine use can cause symptoms of excited delirium and aggression \\\\\\\\\\\\\[ R \\\\\\\\\\\\\]. Observational research has shown that cocaine users are significantly more likely to develop depression \\\\\\\\\\\\\[ R \\\\\\\\\\\\\] and psychosis \\\\\\\\\\\\\[ R \\\\\\\\\\\\\]. On the flip side, cocaine addiction is also a consequence of depression and other mental health disorders. Although rare, higher doses can cause hallucinations or false sensory perceptions \\\\\\\\\\\\\[ R \\\\\\\\\\\\\]. Abstinence from cocaine use can create withdrawal symptoms like mood disturbances and cravings \\\\\\\\\\\\\[ R \\\\\\\\\\\\\]. Cocaine can alter and impair chemical and physical balance homeostasis , wakefulness, and sleep due to chemical changes in the brain \\\\\\\\\\\\\[ R \\\\\\\\\\\\\]. In animals studies, cocaine disrupted normal sleep patterns \\\\\\\\\\\\\[ R \\\\\\\\\\\\\]. More specifically, cocaine can lead to a reduction in REM rapid eye movement sleep, which has also been associated with depression. Cocaine use impairs the normal sleep cycle, while dependence causes associated profound sleep problems \\\\\\\\\\\\\[ R \\\\\\\\\\\\\]. Sustained abstinence in cocaine addicts will produce insomnia and decreased sleep \\\\\\\\\\\\\[ R \\\\\\\\\\\\\]. Consequently, sleep disturbances and insomnia can cause depression and lead suicide \\\\\\\\\\\\\[ R \\\\\\\\\\\\\]. Long-term cocaine use can negatively impact the cognitive functions of the brain. A preliminary study based on arithmetics and memory showed brain impairment in 20 heavy cocaine abusers \\\\\\\\\\\\\[ R \\\\\\\\\\\\\]. Long-term cocaine use worsened cognitive functions including memory, attention, and decision-making. Magnetic resonance imaging MRI studies have shown that cocaine deactivates or decreases the activity in many regions of the brain anterior cingulate, anterior insula, striatum, cingulate gyrus, frontal gyrus, and right prefrontal cortex \\\\\\\\\\\\\[ R \\\\\\\\\\\\\]. Cocaine reduced memory and learning neurobehavioral performance and these effects lasted for up to 4 weeks of abstinence in 56 chronic cocaine users \\\\\\\\\\\\\[ R \\\\\\\\\\\\\]. The acute respiratory symptoms of smoking cocaine include coughing with sputum, chest pain, shortness of breath, coughing of blood hemoptysis , and worsening of asthmatic symptoms \\\\\\\\\\\\\[ R \\\\\\\\\\\\\]. Prolonged exposure to cocaine can lead to obstructive pulmonary disease transient pulmonary infiltrates , airway obstruction, and fever \\\\\\\\\\\\\[ R \\\\\\\\\\\\\]. A case report of a year-old university student showed that sniffing cocaine could also lead to damage and inflammation of the lung cellulose granuloma \\\\\\\\\\\\\[ R \\\\\\\\\\\\\]. Other reports indicated that inhalation of freebase cocaine could directly damage the pulmonary gas exchange surface \\\\\\\\\\\\\[ R \\\\\\\\\\\\\]. When oxygen demand is high, blood vessels normally expand to increase blood flow and oxygen delivery. However, cocaine causes blood vessels to constrict, increasing the overall blood pressure while decreasing the overall oxygen delivered. This can lead to damaging of the blood vessels atherosclerotic lesions \\\\\\\\\\\\\[ R \\\\\\\\\\\\\]. The risk of an acute heart attack is increased 24 times after cocaine use in relatively low-risk individuals \\\\\\\\\\\\\[ R \\\\\\\\\\\\\]. An autopsy performed on 40 subjects who were positive for cocaine revealed that cocaine use leads to inflammation and damage to the heart muscle myocarditis \\\\\\\\\\\\\[ R \\\\\\\\\\\\\]. Intravenous cocaine use can increase the chances of bacterial infections endocarditis and also damages the heart \\\\\\\\\\\\\[ R , R \\\\\\\\\\\\\]. Cocaine abusers also have a higher prevalence for coronary artery aneurysms \\\\\\\\\\\\\[ R \\\\\\\\\\\\\]. Besides cocaine, the coca leaves contain essential nutrients such as vitamins and minerals and have many health benefits \\\\\\\\\\\\\[ R \\\\\\\\\\\\\]. Chewing coca leaves can treat gut symptoms, environmental stress, hunger, and altitude sickness through brain stimulation and mood elevating properties \\\\\\\\\\\\\[ R , R \\\\\\\\\\\\\]. However, refined cocaine is a very powerful stimulant that has a limited number of health benefits. These health benefits do NOT counteract the addictiveness and side effects of cocaine. The numbing properties of cocaine make the drug an ideal anesthetic for surgical practices \\\\\\\\\\\\\[ R \\\\\\\\\\\\\]. Cocaine, when combined with other compounds tetracaine and adrenaline , can be used as a topical anesthetic for minor facial and scalp lacerations \\\\\\\\\\\\\[ R \\\\\\\\\\\\\]. Finally, cocaine effectively constricts the blood vessel, treating minor skin lacerations and restricting bleeding \\\\\\\\\\\\\[ R \\\\\\\\\\\\\]. Cocaine decreases storage and increases the breakdown of fat through its effects on the brain neuropeptide CART while maintaining fat appetite \\\\\\\\\\\\\[ R \\\\\\\\\\\\\]. Animal studies have demonstrated that both food reward and cocaine increased dopamine release in the brain nucleus accumbens \\\\\\\\\\\\\[ R , R \\\\\\\\\\\\\]. Also, cocaine produces a feeling of fullness, which is controlled by dopamine actions in different parts of the brain nucleus accumbens core \\\\\\\\\\\\\[ R \\\\\\\\\\\\\]. However, given the adverse effects of cocaine consumption, its effects on weight loss are often overlooked. Consumption of high doses of cocaine can result in overdose or poisoning. Cocaine overdose results in experiencing an augmentation of its adverse side effects. Symptoms include \\\\\\\\\\\\\[ R , R \\\\\\\\\\\\\]:. Depletion of dopamine leads to depression, decreased cognitive function, and fatigue. Tyrosine can come from nutritional supplements \\\\\\\\\\\\\[ R \\\\\\\\\\\\\] or food sources such as chicken, turkey, soy products, or fish. There are many different strategies or treatments for cocaine addiction. One approach is through cognitive-behavioral therapy CBT. CBT utilizes several important tasks to combat cocaine addiction, including \\\\\\\\\\\\\[ R , R \\\\\\\\\\\\\]:. According to the book Cocaine Changes: The Experience of Using and Quitting by Dan Waldorf, cocaine users fall into 1 of 4 categories of cocaine use: The book followed and interviewed cocaine users about their experience using cocaine. Most of the respondents found cocaine to be fun and associated the drug with a positive atmosphere such as friends and music. Because the drug has different effects on different individuals, many users feel energized by its mood enhancing effects \\\\\\\\\\\\\[ R \\\\\\\\\\\\\]. Cocaine allowed the user to feel glamorous and helped perform in front of a live audience. However, in the end, cocaine produced a sense of paranoia that ultimately inhibited normal day-to-day functioning. I had to spend literally thousands of hours trying to read through studies on pubmed to figure out how the body worked and how to fix it. We do not aim to diagnose, treat, cure or prevent any illness or disease. Information is shared for educational purposes only. You must consult your doctor before acting on any content on this website, especially if you are pregnant, nursing, taking medication, or have a medical condition. No natural extract or pharmacutical chemical will effect everyone the same way. When we are condition to different environments and exposed long term exposure of negative conditions it will change mental and physical state of being and feeling. Cocaine has no medicinal value whatsoever, outside of being topical analgesic. You will always want more. First few times might be bliss al da.. If you want to know what it is — do a line. You will not be addicted in the click of a finger. And you can then see actually a bit of a anti Climax or disappointment. It is definitely not a drug to defend — it has hurt too many lives. So has alcohol — so has supporting the wrong political party where I come from I think this forum is a gentle shake of the head to Hollywood and the media for sometimes, sometimes blaming it when there are deeper demons at work. I have had depression since 15 — and have tried both Herbal remedies , and prescription. I will never go off my anti depressants — and I have rules. Never if you have work the next day. It needs to be a RESPECTED drug that I believe if you are strong enough — you can control and enjoy it time and a place as always — if you over indulge — be honest — put it down — take a benzo — and walk away — so that there can be a next time. One of the better less opinionated forums to chat on — thanks. I have a brain disorder related to the production of serotonin and dopamine in my brain, I have been treated for many years with pharmaceutical drugs and I have never been able to solve my problem. The side effects of these remedies are the worst part, some of them are muscle aches, difficulty sleeping, difficulty concentrating, irritation, discomfort, and many other problems, I really stopped feeling sad and having suicidal thoughts, but in return I won several other problems which made me worse, physically and psychologically. My experience with cocaine was different from these pharmaceutical remedies. I really feel better getting cocaine in my daily life. Would be great if you could include information about how cocaine affects the menstrual cycle and fertility. However, cocaine causes a spike in levels of the hormone prolactin. In high amounts, prolactin can inhibit ovulation, causing hormonal imbalances and delayed, irregular periods. These effects would normally be from regular abuse. There is a similarity in prolactin levels between heavy cocaine users and sufferers of Polycystic Ovary Syndrome, where some patients can suffer from fertility problems due to a lack of ovulation; hence women who abuse cocaine may difficulty conceiving. He was also depressed. The reason why cocaine is illegal is because it helps people with mental health issues to fix their logic and get on the business which is against the interests of pharmaceutical corporations and Drs, it also helps against electronic harassment and covert gang stalking operations from the gov of good samaritans being targeted and spurred into crime in which case If it is consumed more intellect, logic and alertness for work is the outcome. Cocaine is a stimulant and can work as an antipsychotic to remove depression and anxiety it can also remove depression and make your logic work better. Been on psychiatric medications for about 20 years. There was a time when I used cocaine for about 6 months. Best part of my life. Psychiatric medications take away any reward system and causes you to just feel fearful or angry. Really appreciate that you would include articles about recreational drugs and your experiences. Your email address will not be published. Notify me of follow-up comments by email. Notify me of new posts by email. At the age of 25, with lots of questions and very few satisfying answers, Joe decided to embark on a journey of self-experimentation - something that has since become known as 'bio-hacking'. He founded SelfHacked about 4 years ago and without any funds has transformed it to the fastest growing health website and the largest biohacking website, getting 1. He also founded SelfDecode which has become a leading platform for analyzing genetics for health information Creatine nitrate blends the benefits of dietary creatine and nitrates. It enhances exercise performance by increasing endurance, muscle mass gain, and fatigue resistance. 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Mario Submitted June 20, Todd P Submitted May 28, Maxine Submitted March 30, Pedro Submitted March 18, Samahdi Submitted February 16, Alfredo Submitted January 15, Kim Submitted January 3, Red Submitted October 17, My understanding is that it can actually make psychosis worse. Ricardo Submitted October 4, Mike Submitted August 5, Bill Belmonte Submitted July 13, Leave a Reply Cancel reply Your email address will not be published. About Joe At the age of 25, with lots of questions and very few satisfying answers, Joe decided to embark on a journey of self-experimentation - something that has since become known as 'bio-hacking'. Dietary supplements Creatine Nitrate: Benefits, Side Effects, Dosage, Reviews. 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