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PAIN MANAGEMENT- NEW DISCOVERIES AND TREATMENT OPTIONS IN ABUSE DETERRENT ERA

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This document provides an overview of pain management technologies and treatments, with a focus on abuse-deterrent formulations of opioids. It discusses the FDA's efforts to address the opioid epidemic through new guidelines for abuse-deterrent drugs and formulations. Several approved and pipeline abuse-deterrent opioid formulations are described, along with their drug delivery technologies. Emerging non-opioid treatments for pain including new drug targets and mechanisms of action are also reviewed, which may help reduce opioid use. The document aims to analyze the impact of regulatory changes and new technologies on the opioid drug market in both the US and Europe. Read less. AI-enhanced description. Download now Download to read offline. More Related Content. But they have some limitation for restricting abuse mainly through oral intake- swallowing a number of intact tablets or capsules. New NCEs targeting Opioids receptor are in pipeline which reduces Opioids abuse by its MoA slow rate of entry in Brain and may have potential to deal with reducing opioid abuse through restricting oral intake in coming years. In this report, we have discussed a number of novel delivery technologies employed in formulating abuse deterrent product, technologies employed in enhancing patient compliances, emerging novel mechanisms and late stage pipeline drugs in the management of pain. Table of Contents 1. Executive Summary a. Late stage pipeline drugs and new MoA — which has potential to reduce Opioid use in moderate pain? IR opioids- Abuse deterrent potential 3. Abuse Deterrent Technology Platforms employed in marketed drugs and pipeline a. DETERx f. IntelliPaste h. INTAC j. Implantable pump for intrathecal delivery l. Small molecule delivery n. Bio-MD-prodrugs platform o. Ligand activated Therapy LAT p. Inspirion delivery Technologies t. Intellitab Technology u. Trigger lock platform —Micropump v. Pain Therapeutics x. Fenrock y. Smart Patch PNS system z. Acuform Technology cc. OROS Technology dd. Resistec Technology ee. Multi-day formulation of Tramadol b. Bio-MD Platform c. Orexo- Sublingual technology d. Fentanyl based therapy formulation modification micro and nano tab e. Acorda Therapeutics f. Bilayered oral formulation- Charleston lab g. ZilrettaTM h. Steroidal intraarticular injection i. Intrathecal drug delivery system j. Oromucosal delivery New mechanisms in Pain management a. Angiotension II antagonist b. Anti-NGF c. Ligand Activate Therapy d. CB agonist g. Kappa Receptor agonists h. TrkA receptor antagonist i. MAP kinase inhibitor j. Opioid alternatives dexmedetomidine k. Peptide Therapeutics conopeptide l. TRPV1 antagonist m. Gene therapy n. Late stage pipeline developments in neuropathic pain a. Mirogabalin- Key MOA diff vs. CL d. Hydromorphone e. Sativex h. Once daily pregabalin i. Topical clonidine gel j. Topical ketamine and amitraline k. Amorsa therapeutics l. Pregabalin CR m. Eladur n. GRC o. DWP p. AVP q. Download now.

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