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Citation: Sherif W. Mansour, Sadeen K. Zein Eddin, Julie F. Owaidat, Saja N. Zuaiter, Dania M. Belbeisi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Adverse effects of the vaccination have not been fully recorded. That is why reporting side effects and conducting specific measures regarding the side effects is crucial. Objective: The aim of the present study is to document vaccine side effects, if recorded, associated with the different types of COVID vaccines among medical students at Mutah University in Jordan. Method: Prospective survey study that was started on January 4th, till 20th of March, It was conducted on medical students at Mutah University in Jordan. Statistical analysis was done using SPSS version Results: The results of the present study showed that the most common adverse effect encountered proved to be pain at the site of injection. Tiredness, muscle pain, headache, chills, redness, and swelling at the site of injection were also highly reported. Participants that were infected with COVID before the vaccination reported more side effects than the ones who were infected with the virus after the vaccination. Conclusion: To conclude, we found that COVID vaccine recipients experienced side effects including muscle pain, chills, dizziness and tiredness. COVID was discovered during the outbreak of the highly transmissible respiratory disease in Wuhan, China, in and has emerged as a significant public health concern Phelan et al. The virus spread rapidly among many countries resulting in a necessity for preventive measures such as social distancing, hand hygiene, travel restrictions, and countrywide lockdowns Mathieu et al. The health ministry prioritized vaccine distribution starting with high-risk groups, followed by a mass vaccination campaign targeting all strata of society. At the same time, allergic reaction myocarditis, palpitations and vaccine-induced immune thrombotic thrombocytopenia were also reported at a lower rate Saeed et al. While many review studies have compared the different side effects of each type of vaccine, few studies were found evaluating the association with the number of doses and other factors that could contribute to varying side effects. Study design and population: For this cross-sectional research study, an online survey was distributed to medical students at Mutah University, School of Medicine. The study participants were medical students from both primary and clinical years first up to sixth year including males and females from all nationalities. We used a simple random sampling method for selecting the target sample. The privacy of data was maintained. Questionnaire The survey was administered through an online Google form. The language used was English with some parts translated to Arabic. The questionnaire consisted of six main sections with 32 questions. In these sections, the survey asked about the vaccine type, place of vaccination, side effects on the site of injection, and other side effects of the vaccine. The fifth and sixth sections contained questions regarding COVID infection and its relationship with the vaccine. The online questionnaire was distributed through medical social media groups Facebook, WhatsApp, Twitter, and Telegram. Population characteristics The sample size of the study consisted of students. The female participants Most of the participants were 1st year medical students, followed by fourth year medical students The age of the participants ranged between 17 and While most of participants who took oxford were from the north. Next followed tiredness, muscle pain, and headache. The least common side effect was DVT. Most of the side effects were more common in the first dose, while DVT and seizure were more common in booster dose. As seen in Figure 2, participants who were infected with covid after the booster dose had the highest incidence of side effects. Those who were infected before getting vaccinated also had relatively high incidence of side effects. Side Effects Related to Bmi 38 participants from 9. Additionally, other factors associated with increased reactogenicity to the COVID vaccine have been reported and discussed further. Our results revealed that participants who had taken the COVID vaccine had experienced side effects including fatigue, pain at the site of injection, muscle pain, chills, and dizziness. The various types of COVID vaccines that are used in Jordan are relatively safe with no reported anaphylaxis or serious complications. Nonetheless, a higher incidence of the side effects was associated with Pfizer vaccine. The most common reported side effects were pain at the site of injection, tiredness, muscle pain, and headache. Other symptoms that were also reported were swelling, redness, and itching at the site of injection. However, there was an obvious increase in the percentage of individuals suffering from local symptoms after the booster third dose of the vaccine, as Figure 1 shows that pain on the site of injection was more prevalent after the third dose. This finding is surprisingly inconsistent with another study done to evaluate the prevalence of side effects of booster dose in Saudi Arabia. Outcomes of the Saudi study portrayed that pain at the site of injection along with fatigue is among the least reported side effects in post booster dose Ali wt al. In addition, it was found that participants that were infected with COVID before the vaccination had more side effects than the ones who were infected with the virus after the vaccination. This is most likely because vaccines have increased immunogenicity and higher antibody titers in individuals with past infection Menni at al. Moreover, the results of the present study documented that females were more commonly affected by the inflammatory and immune response to vaccines. Side effects in women proved to be more prominent and their incidence was higher. Behavioral, genetic, and hormonal elements could be possible triggers to the divergence in adverse events after vaccination in both genders Vassallo et al. The specific underlying mechanisms contributing to this disparity is unknown, however, many theories explained that difference in genetic factors and endogenous opioids between the sexes may be a reason for the variation. Also, some studies showed that sensitivity to pain varies with different sex hormones For instance, one study revealed that estrogen plays a role in stimulating an immune response while testosterone does the opposite. Additionally, many immune-related genes are strongly associated with the X chromosome of which females have two copies while males have only one Al-Qazaz et al. Furthermore, results of present study shed light on the relation between the body mass index and post COVID vaccination effects. Vaccine recipients with normal body mass index experienced more side effects than individuals with high body mass index. In agreement with our results, the Iguacel et al. Similarly, another study by Ebrahimian et al. Overall, the relationship between side effects experienced with COVID vaccine and weight status can be best justified by the concentration of antibody titers Iguacel et al. Many studies suggested that central obesity is among the elements associated with low levels of antibody titers in response to COVID vaccine Watanabe et al. This in fact would explain the low adverse effects individuals with high body mass index experience after receiving COVID vaccine. To conclude, we found that COVID vaccine recipients experienced side effects including pain at the site of injection, tiredness, muscle pain, and headache. Higher reactogenicity to the vaccine was associated with prior COVID infection, female gender, lower BMI, accompanied with no further serious side effects. For statistical comparisons, the percentage is used rather than the original number. As a result, when we compare males and females, we compare the percentage that appeared in females and the percentage that appeared in males, as well as location of residence and other factors. So, it is advisable to encourage whole society to be vaccinated against covid with any available type of vaccine for better protection. Clearly Auctoresonline and particularly Psychology and Mental Health Care Journal is dedicated to improving health care services for individuals and populations. 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Table 3: Side effects related to vaccine type Side Effects Related to Covid Infection As seen in Figure 2, participants who were infected with covid after the booster dose had the highest incidence of side effects. Figure 4: Side effects related to BMI. Al-Qazaz, H. Covid vaccination, do women suffer from more side effects than men? A retrospective cross-sectional study. Pharmacy practice. Infection and Drug Resistance. Sex differences in pain: A brief review of clinical and experimental findings. British journal of anaesthesia. International Journal of Infectious Diseases, , — Nat Hum Behav 5, — The Lancet. Infectious diseases. JAMA, 8 , — International Journal of Infectious Diseases. Patients with history of covid had more side effects after the first dose of covid vaccine. Progress of the COVID vaccine effort: viruses, vaccines and variants versus efficacy, effectiveness and escape. Nature reviews. Immunology, 21 10 , — Frontiers in global women's health, 2, World Health Organization. View at Publisher View at Google Scholar. Mina Sherif Soliman Georgy. Anthony Kodzo-Grey Venyo. Gomez Barriga Maria Dolores. Maria Dolores Gomez Barriga. Dr Maria Dolores Gomez Barriga. Dr Maria Regina Penchyna Nieto.
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