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Jwh 09

JWH 1-pentyl 1-naphthoyl indole or AM \\\\\\\\\\\\\\\\\[1\\\\\\\\\\\\\\\\\] is an analgesic chemical from the naphthoylindole family that acts as a full agonist at both the CB 1 and CB 2 cannabinoid receptors, with some selectivity for CB 2. It produces effects in animals similar to those of tetrahydrocannabinol THC , a cannabinoid naturally present in cannabis, leading to its use in synthetic cannabis products such as 'legal cannabis herbal incense blends' which in some countries are sold legally as 'incense', labeled 'not for human consumption'. Huffman , an organic chemist at Clemson University , synthesized a variety of chemical compounds that affect the endocannabinoid system. JWH is one of these compounds, with studies showing an affinity for the cannabinoid CB 1 receptor five times greater than that of THC. Cannabinoid receptors are found in mammalian brain and spleen tissue; however, the structural details of the active sites are currently unknown. On December 15, , it was reported by the German pharmaceutical company THC Pharm that JWH was found as one of the active components in at least three versions of the herbal blend Spice , which has been sold as an incense in a number of countries around the world since Urine was collected for 24 hours, followed by extraction of JWH metabolites using both liquid-liquid extraction and solid-phase extraction. GC-MS was utilized to separated and identify the extracted compounds. JWH and its N-dealkylated metabolite were only detected in small amounts, with hydroxylated N-dealkylated metabolites comprising the primary signal. The observed mass shift indicates that it is likely that hydroxylation occurs in both the naphthalene and indole portions of the molecule. At least one case of JWH dependence has been reported by the media. Withdrawal symptoms were more severe than those experienced as a result of cannabis dependence. JWH has been shown to cause profound changes in CB 1 receptor density following administration, causing desensitization to its effects more rapidly than related cannabinoids. Cannabinoid receptor full agonists may present serious dangers to the user when used to excess. Various physical and psychological adverse effects have been reported from JWH use. One study reported psychotic relapses and anxiety symptoms in well-treated patients with mental illness following JWH inhalation. JWH usage is readily detected in urine using 'spice' screening immunoassays from several manufacturers focused on both the parent drug and its omega-hydroxy and carboxyl metabolites. The major urinary metabolite is a compound that is monohydroxylated on the omega minus one carbon atom of the alkyl side chain. From Wikipedia, the free encyclopedia. Pharmacy and Pharmacology portal. Drug and Alcohol Dependence. British Journal of Pharmacology. Archived from the original on August 22, A never ending story? Retrieved September 8, The Journal of Neuroscience. Journal of Drug and Alcohol Dependence. Screening for the synthetic cannabinoid JWH and its major metabolites in human doping controls. Sensitive and rapid quantification of the cannabinoid receptor agonist naphthalenyl- 1-pentylindolyl methanone JWH in human serum by liquid chromatography-tandem mass spectrometry. Journal of mass spectrometry: Archived from the original PDF on Retrieved 17 May Retrieved 18 July Retrieved 18 February Archived from the original on Department of Anti-smuggling and Organised Crime. General Directorate of Legislation Development and Publication. Retrieved 11 March Cannabinoid receptor modulators cannabinoids by pharmacology List of: Diphenidine Ephenidine Fluorolintane Methoxphenidine. Dextrallorphan Dextromethorphan Dextrorphan Racemethorphan Racemorphan. Apomorphine Aporphine Bromocriptine Cabergoline Lisuride Memantine Nuciferine Pergolide Phenethylamine Piribedil Pramipexole Ropinirole Rotigotine Salvinorin A Also indirect D 2 agonists, such as dopamine reuptake inhibitors cocaine , methylphenidate , releasing agents amphetamine , methamphetamine , and precursors levodopa. Glaucine Isoaminile Noscapine Pukateine. Agonists abridged; see here for more: Retrieved from ' https: Views Read Edit View history. In other projects Wikimedia Commons. This page was last edited on 28 July , at By using this site, you agree to the Terms of Use and Privacy Policy. The Austrian Ministry of Health announced on 18 December that Spice would be controlled under Paragraph 78 of their drug law on the grounds that it contains an active substance that affects the functions of the body, and the legality of JWH is under review. JWH is claimed to be a controlled substance in Canada though it is not listed under schedule 2 synthetic cannabinoids. Health Canada is of the opinion that 'similar synthetic preparations' covers jwh though jwh is not similar in chemical structure nor in its action of the CB1 receptor. China has made JWH Illegal for sale. It is illegal to import or export JWH The seizure of 2C-B in blue pill form on 13 October and the seizure of 0. Upon these reports the EWS committee initiated the regulation process by warning the Ministry of Health. The regulation is in effect since 13 February The Anti-narcotics department declared synthetic cannabinoids and their analogues illegal after an outbreak of JWH containing product referred to as 'Joker'. CB 1 Agonists abridged; see here for more:

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