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Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section. It is not a recommendation and should be verified with other sources for accuracy. JWH is an analgesic chemical from the naphthoylindole family that acts as a partial agonist at both the CB1 and CB2 cannabinoid receptors. It is somewhat selective for the CB1 subtype, with affinity at this subtype approximately 5x the affinity at CB2. Huffman , one of the inventors of the compound. JWH gained popularity in April , when it was claimed by chemists at the University of Freiburg to have been found in a 'fertilizer' product called 'Forest Humus', along with another synthetic cannabinoid, CP 47, Cannabinoids are commonly smoked or vaporized to achieve a quick onset of effects and rapid offset. JWH is orally active when dissolved in a lipid, which can increase the duration significantly. Like other cannabinoids , it is insoluble in water but dissolves in ethanol and lipids. Unlike cannabis , the chronic abuse of synthetic cannabinoids has been associated with multiple deaths and more dangerous side effects and toxicity in general. Therefore, it is strongly discouraged to take this substance for extended periods of time or in excessive doses. JWH, or Naphthalenyl- 1-butylindolyl methanone, is a synthetic cannabinoid containing a substituted indole structure. JWH is substituted at R 1 with a butyl chain. Additionally, the indole core is substituted at R 3 with a carbonyl group which is also bonded to a napthalene moeity. Napthalene is a bicyclic structure of two fused benzene rings. This carbonyl bridge of JWH classifies it as a ketone. JWH is an analog of THJ in which the core indazole structure is substituted with an indole base. However, studies on animals have shown a higher binding profile than THC. The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects should be taken with a grain of salt and will rarely if ever occur all at once, but heavier doses will increase the chances and are more likely to induce a full range of effects. Likewise, adverse effects become much more likely on higher doses and may include injury or death. There are currently no anecdotal reports which describe the effects of this compound within our experience index. Additional experience reports can be found here:. JWH, unlike many synthetic cannabinoids, is a partial agonist of the CB1 receptors. Because JWH is a partial agonist, unlike most cannabinoids, harm mediated by CB1 receptor agonism can be less severe than its full agonist counterparts. JWH has been shown to cause profound changes in CB1 receptor density following administration, causing desensitization to its effects more rapidly than related cannabinoids with partial agonism. As synthetic cannabinoids are active in the milligram range with below 5mg being a common dose , it is important to use proper precautions when dosing to avoid a negative experience. It is strongly recommended that one use harm reduction practices when using this drug. As with other synthetic cannibanoids, the chronic use of JWH can be considered moderately addictive with a high potential for abuse and is capable of causing psychological dependence among certain users. When addiction has developed, cravings and withdrawal effects may occur if a person suddenly stops their usage. Tolerance to many of the effects of JWH develops with prolonged and repeated use. This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about 3 - 7 days for the tolerance to be reduced to half and 1 - 2 weeks to be back at baseline in the absence of further consumption. JWH presents cross-tolerance with all cannabinoids , meaning that after the consumption of JWH all cannabinoids will have a reduced effect. Retrieved from ' https: Psychoactive substance Cannabinoid Substance. Navigation menu Personal tools English Create account Log in. Views Read View source View history. Community Network Youtube Good vibes.

Jwh 073

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JWH , a synthetic cannabinoid , is an analgesic chemical from the naphthoylindole family that acts as a partial agonist at both the CB 1 and CB 2 cannabinoid receptors. It is somewhat selective for the CB 1 subtype, with affinity at this subtype approximately 5x the affinity at CB 2. Huffman , one of the inventors of the compound. On 20 April , JWH was claimed by researchers at the University of Freiburg to have been found in a 'fertiliser' product called 'Forest Humus', along with another synthetic cannabinoid C8 - CP 47, Its effects are produced by binding and acting as an agonist to the CB 1 and CB 2 cannabinoid receptors. The CB 1 receptor is found in the brain. JWH bind to CB 1 with a higher affinity than THC, suggesting that taking more too soon after the initial dose could lead to diminished effects. CB 2 is found outside the brain, mostly in the immune system. A search in the literature yielded no published studies of the effects of JWH in humans, but these studies in animals suggest with high probability that JWH produces effects very similar to those of THC in humans. From Wikipedia, the free encyclopedia. Pharmacy and Pharmacology portal. A never ending story? Archived from the original on August 3, Retrieved August 5, Retrieved 11 March Archived from the original PDF on June 4, Retrieved August 2, Cannabinoid receptor modulators cannabinoids by pharmacology List of: Diphenidine Ephenidine Fluorolintane Methoxphenidine. Dextrallorphan Dextromethorphan Dextrorphan Racemethorphan Racemorphan. Apomorphine Aporphine Bromocriptine Cabergoline Lisuride Memantine Nuciferine Pergolide Phenethylamine Piribedil Pramipexole Ropinirole Rotigotine Salvinorin A Also indirect D 2 agonists, such as dopamine reuptake inhibitors cocaine , methylphenidate , releasing agents amphetamine , methamphetamine , and precursors levodopa. Glaucine Isoaminile Noscapine Pukateine. Agonists abridged; see here for more: Retrieved from ' https: Views Read Edit View history. This page was last edited on 10 September , at By using this site, you agree to the Terms of Use and Privacy Policy. CB 1 Agonists abridged; see here for more:

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