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Острые отравления синтетическими каннабиноидами («Спайсами»)

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Синтетические каннабиноиды. Состояние проблемы

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JWH , А синтетические каннабиноиды , является анальгетиком химическим из naphthoylindole семьи , который действует как частичный агонист как на CB 1 и СВ 2 каннабиноидов рецепторах. Это несколько селективным для CB 1 подтипа, со сродством при этом подтипе приблизительно 5x сродство в СВ 2. Huffman , один из изобретателей соединения. Эти претензии были подтверждены в июле года , когда испытание специй продукта, захваченном после официального запрета на JWH ушло в силу в Германии, как были показаны, содержат нерегулируемое соединение JWH вместо этого. Его эффекты получают путем связывания и действовать в качестве агониста к CB 1 и СВ 2 каннабиноидных рецепторов. CB 1 рецепторов в мозге. JWH связывается с СВ 1 с более высоким сродством , чем ТНС, предполагая , что принятие более слишком скоро после первоначальной дозы может привести к уменьшенным эффектам. CB 2 находится вне мозга, в основном в иммунной системе. Поиск в литературе не дал никаких опубликованных исследований последствий JWH в организме человека, но эти исследования на животных свидетельствуют о высокой вероятности того, что JWH производит эффекты, очень похожие на те, ТНС в организме человека. США DEA временно объявил JWH график I контролируемое вещество на 1 марта через 76 FR , и постоянно восстановлены один и тот же график на 9 июля в разделе из закона пищевых продуктов и медикаментов безопасности и инноваций. JWH считается Schedule 9 запрещенным веществом в Австралии по стандарту ядов октябрь Source Authors. Интерактивное изображение. Смотрите также: JWH Фармация и фармакология портал.

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WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section. It is not a recommendation and should be verified with other sources for accuracy. JWH is an analgesic chemical from the naphthoylindole family that acts as a partial agonist at both the CB1 and CB2 cannabinoid receptors. It is somewhat selective for the CB1 subtype, with affinity at this subtype approximately 5x the affinity at CB2. Huffman , one of the inventors of the compound. JWH gained popularity in April , when it was claimed by chemists at the University of Freiburg to have been found in a 'fertilizer' product called 'Forest Humus', along with another synthetic cannabinoid, CP 47, Cannabinoids are commonly smoked or vaporized to achieve a quick onset of effects and rapid offset. JWH is orally active when dissolved in a lipid, which can increase the duration significantly. Like other cannabinoids , it is insoluble in water but dissolves in ethanol and lipids. Unlike cannabis , the chronic abuse of synthetic cannabinoids has been associated with multiple deaths and more dangerous side effects and toxicity in general. Therefore, it is strongly discouraged to take this substance for extended periods of time or in excessive doses. JWH, or Naphthalenyl- 1-butylindolyl methanone, is a synthetic cannabinoid containing a substituted indole structure. JWH is substituted at R 1 with a butyl chain. Additionally, the indole core is substituted at R 3 with a carbonyl group which is also bonded to a napthalene moeity. Napthalene is a bicyclic structure of two fused benzene rings. This carbonyl bridge of JWH classifies it as a ketone. JWH is an analog of THJ in which the core indazole structure is substituted with an indole base. However, studies on animals have shown a higher binding profile than THC. Disclaimer: The effects listed below are cited from the Subjective Effect Index SEI , which relies on assorted anecdotal reports and the personal experiences of PsychonautWiki contributors. As a result, they should be taken with a healthy amount of skepticism. Likewise, adverse effects become much more likely on higher doses and may include serious injury or death. There are currently no anecdotal reports which describe the effects of this compound within our experience index. Additional experience reports can be found here:. JWH, unlike many synthetic cannabinoids, is a partial agonist of the CB1 receptors. Because JWH is a partial agonist, unlike most cannabinoids, harm mediated by CB1 receptor agonism can be less severe than its full agonist counterparts. JWH has been shown to cause profound changes in CB1 receptor density following administration, causing desensitization to its effects more rapidly than related cannabinoids with partial agonism. As synthetic cannabinoids are active in the milligram range with below 5mg being a common dose , it is important to use proper precautions when dosing to avoid a negative experience. It is strongly recommended that one use harm reduction practices when using this drug. As with other synthetic cannibanoids, the chronic use of JWH can be considered moderately addictive with a high potential for abuse and is capable of causing psychological dependence among certain users. When addiction has developed, cravings and withdrawal effects may occur if a person suddenly stops their usage. Tolerance to many of the effects of JWH develops with prolonged and repeated use. This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about 3 - 7 days for the tolerance to be reduced to half and 1 - 2 weeks to be back at baseline in the absence of further consumption. JWH presents cross-tolerance with all cannabinoids , meaning that after the consumption of JWH all cannabinoids will have a reduced effect. Although many psychoactive substances are reasonably safe to use on their own, they can quickly become dangerous or even life-threatening when combined with other substances. The list below includes some known dangerous combinations although it cannot be guaranteed to include all of them. Independent research e. Google , DuckDuckGo should always be conducted to ensure that a combination of two or more substances is safe to consume. Some interactions listed have been sourced from TripSit. Physical effects. Cognitive effects. Visual effects. Auditory effects. Cannabinoids as therapeutic agents. ISBN Synthetic cannabinoid use and psychosis: an explorative study. Journal of Drug and Alcohol Dependence Retrieved December 30, Bundesgesetzblatt Jahrgang Teil I Nr. Bundesanzeiger Verlag. December 23, Retrieved December 19, Archived from the original on March 21, September ' PDF in German. Federal Chancellery of Switzerland. September 10, Categories : CS1 German-language sources de All articles with unsourced statements Articles with unsourced statements Psychoactive substance Cannabinoid Indole Substance. Navigation menu Personal tools Create account Log in. Namespaces Page Discussion. Views Read View source View history. Community Network YouTube Good vibes.

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