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In this Review, we highlight recent advances in our understanding of the complex regulation of the mTOR pathway and discuss its function in the context of physiology, human disease and pharmacological intervention. Using cryo-electron microscopy and molecular characterization, David Sabatini and colleagues provide crucial new insights that validate and expand their model of how amino acids are sensed and signal at the lysosome to activate mechanistic target of rapamycin complex 1 (mTORC1) and cell growth-regulating processes. period rtng gms rapid rtng rapid gms blitz rtng blitz gms. Aout 2024 (3 mois) - Protocole d'Audit de Verification du Respect au Standard - exigence sanitaire - UAP - Évaluation de la gestion de crise : analyse efficience, adhérence depuis confinement - Automatisation du suivie des indicateurs de l'UAP - Conception d'un tableau de marche numérique (standardisation, communication, Excel) Jocelyn SABATINI.