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Background: Buprenorphine dosage is a crucial factor influencing outcomes of buprenorphine treatment for heroin use disorders. Therefore, the aim of the present study is to identify naturally occurring profiles of heroin-dependent patients regarding individualized management of buprenorphine dosage in clinical practice of buprenorphine-naloxone maintenance treatment. Methods: patients receiving buprenorphine-naloxone maintenance treatment were surveyed at 16 Spanish centers during the stabilization phase of this treatment. Patients were grouped using cluster analysis based on three key indicators of buprenorphine dosage management: dose, adequacy according to physician, and adjustment according to patient. The clusters obtained were compared regarding different facets of patient clinical condition. Results: Four clusters were identified and labeled as follows buprenorphine average dose and percentage of participants in each cluster are given in brackets : 'Clinically Adequate and Adjusted to Patient Desired Low Dosage' 2. Compared to patients from the other three clusters, participants in the latter cluster reported more frequent use of heroin and cocaine during last week, lower satisfaction with buprenorphine-naloxone as a medication, higher prevalence of buprenorphine-naloxone adverse effects and poorer psychological adjustment. Conclusions: Our results show notable differences between clusters of heroin-dependent patients regarding buprenorphine dosage management. We also identified a group of patients receiving clinically inadequate buprenorphine dosage, which was related to poorer clinical condition. Keywords: Buprenorphine-naloxone treatment; Cluster analysis; Dosage management; Heroin dependence; Treatment outcomes. Abstract Background: Buprenorphine dosage is a crucial factor influencing outcomes of buprenorphine treatment for heroin use disorders.
Inside the drug capital of Spain – and the 'gateway' for illicit substances entering the EU
Jerez de la Frontera buy Heroin
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Jerez de la Frontera buy Heroin
Inside the drug capital of Spain – and the 'gateway' for illicit substances entering the EU
Jerez de la Frontera buy Heroin
Jerez de la Frontera buy Heroin
Inside the drug capital of Spain – and the 'gateway' for illicit substances entering the EU
Jerez de la Frontera buy Heroin
Jerez de la Frontera buy Heroin
Jerez de la Frontera buy Heroin
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Jerez de la Frontera buy Heroin