In pain redhead study tolerance

In pain redhead study tolerance
A study in mice revealed the mechanisms that may link red hair with greater pain tolerance.
New research reveals how the MC1R gene mutation gives redheads a unique pain response and higher anesthesia resistance. Here's what science says about red hair and pain sensitivity.
Mass General is recognized as a top hospital on the U.S. News & World Report Best Hospitals Honor Roll for 2025-2026.
Anyone with red hair issued urgent warning over painkillers A 2021 study found a fascinating link between redheads and pain tolerance levels
Studies show that redheads report the onset of cold pain perception and cold pain tolerance at significantly higher temperatures than those with dark hair. They also tend to have a lower tolerance for heat pain, feeling discomfort at a lower temperature threshold.
A number of studies have shown redheads feel pain differently and have surprising physical reactions to it. But it's not as simple as saying that redheads are more or less tolerant to pain ...
Humans and mice with red hair have a different tolerance for pain because their skin's pigment-producing cells lack the function of a certain receptor. Lack of this receptor function causes ...
Red hair has been linked to altered sensitivity to pain, analgesics, and hypnotics. This alteration may be impacted by variants in the melanocortin-1 receptor (MC1R) gene, which are mainly found in redheads. The aim of this narrative review was to ...
Given the range of pain sensitivity and different types of pain, pain management can present challenges for people with red hair. Studies show redheads may require higher doses of some types of non-opioid pain relievers. But, the 2021 study mentioned above found that redheads may be more sensitive to opioids and need less medication to stop pain.
The imbalance of these two hormones, OPRM1 being the predominant hormone, leads to the need for more anesthesia during medical procedures. Research has shown that the pain threshold in redheads, due to MC1R, exhibit a higher pain tolerance than non-redheads. While this study was performed on mice, the MC1R gene functions in similar fashion in ...
Dec 11, 2025
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BOSTON — Redheads have a reputation for being hot-tempered. They also are said to have a higher pain threshold than others. Although there may not be scientific proof of their short fuse, according to a recent study, there may be some science behind their pain tolerance.
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Why do redheads potentially need different anesthetic doses, and how does their hair color affect pain medication requirements? Find out the answer in this article.
A new study seems to suggest a link between melanocytes, the cells that determine hair color, and pain tolerance, with redheads faring well.
A Massachusetts General Hospital study may have found why redheads have a different tolerance for pain.
Their sensitivity to pain is different than people with other hair colors, and it also plays a role when it comes to taking analgesics. Red hair is caused by a mutation in the MC1R gene (2).
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For example, in one study, older individuals reported more head and chest pain, but less genital pain (Shega et al., 2014), but another study did not find age-related patterns to pain reporting among older adults (Riley et al., 2014).
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Redheads may be more sensitive to thermal induced pain [3] but have equal sensitivity to ischaemic pain [4]. It is important to note that not all studies agree: Gradwohl et al. were unable to find any differences between anaesthetic or pain sensitivity in a study of patients undergoing surgery [5].
This dual function suggests a biological link between red hair and pain signal processing. Scientific Studies on Pain Perception Research on pain perception in redheads is complex, showing nuanced experiences rather than simple higher or lower tolerance. Studies reveal differing sensitivities to various pain types.
You may have seen the recent (and well-publicized) study that shows redheads are more scared of the dentist than other people are. The idea is that the same gene variant that leads to red hair also — for some reason — makes people more susceptible to pain, and less receptive to the common ane...
A new study shows that redheaded people have the highest pain tolerance of all people, thanks to a unique pain receptor.
Moreover, women expressing non-functional MC1Rs display greater analgesia from opioid analgesia. If redheads in general respond differently to pain and analgesics, this is of clinical importance. The aim of this study was therefore to investigate pain sensitivity and experimentally induced sensitisation in red haired females.
Recent research offers insights into why individuals with red hair experience altered sensitivity to specific types of pain. Study in red-haired mice uncovers mechanisms involved and suggests new treatment strategies for pain. New research led by investigators at Massachusetts General Hospital (MGH ...
Redheads represent only 2% of the world's population. What's more, they feel pain differently than others. Researchers now know why.
May 29, 2024
Redheads are rumored feel more pain and need more painkillers than their blonde and brown-haired cousins, but the science itself is murky.
Redheads are involved in many myths, some actually being backed with scientific evidence. Do they really feel pain differently than others, bleed more, need more anesthesia?
His research firmly suggests that redheads do feel more pain: Not only do they have lower response to anesthetics, redheads also show a more acute response to pain from heat, the study results show.
(NIH Research Matters) Study finds link between red hair and pain threshold. Associated research findings from the National Library of Medicine.
Do redheads experience pain differently, and how should dentists adapt their care? Explore the intriguing connection between red hair, pain sensitivity, and dental anxiety.
Dec 29, 2024
A new study from Massachusetts General Hospital provides insight into why redheads have a higher pain tolerance than blondes and brunettes.
Redheads are more sensitive to some kinds of pain and less sensitive to others. The explanation for these differences could be found in their genetic makeup.
The research is spotty, according the NIH. A 2021 mouse study showed that mice carrying MC1R gene found in people with red hair had a higher pain tolerance, but the reason isn't well understood.
TIL That redheads experience more pain and require about 20% more anesthesia when going into surgery because a gene that influences their red hair color also influences pain receptors in the body.
To investigate the mechanisms behind different pain thresholds in red-haired individuals, Fisher and his colleagues studied a strain of red-haired mice that (as in humans) contains a variant that ...
WebMD investigates what factors influence your pain tolerance including gender, athleticism, mental health, and even hair color.
A new study has found that redheads are more than twice as likely to avoid a visit to the dentist - possibly because they are more sensitive to pain. But does hair colour really mean more discomfort in the dentist chair? Nicole Kidman, Hazel Blears and Prince Harry may all share ginger coloured ...
The science on redheads and their sensitivity to pain is complicated. Anne Nugent Guignon, MPH, RDH, CSP, investigates how current research translates to pain management and anesthesia...
Contrast this with by a team at McGill University in Montreal which concluded that both male and female redheads required less morphine to dull their pain than non-redheads, while redheaded women needed less of a particular opioid for labour-pain than women with darker hair. So, do redheads have a higher or lower tolerance to pain?
Another study from the University of Louisville demonstrated that redheads were more sensitive to thermal pain but less responsive to electrical stimulation. These findings suggest that the type of stimulus matters when assessing pain sensitivity among redheads.
Moreover, women expressing non-functional MC1Rs display greater analgesia from opioid analgesia. If redheads in general respond differently to pain and analgesics, this is of clinical importance. The aim of this study was therefore to investigate pain sensitivity and experimentally induced sensitisation in red haired females.
Redheads have a reputation for being hot-tempered and to have a higher pain threshold than others. Although there may not be scientific proof of their short fuse, there may be some science behind t…
Turns out, the redheads needed about 20 percent more anesthetic to relieve the pain (confirming the common belief among anesthesiologists that redheads are tough to knock out).
Endorphins have several functions, but one of their primary roles is to provide pain relief. This ultimately affects how the body receives pain signals from the brain, causing a heightened sensitivity to prescription opioid painkillers. As a result, redheads can take smaller doses of these drugs to reach the same level of pain tolerance as ...
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Natural redheads experience pain differently from the rest of us. They may need up to 20 percent more anesthesia to be sedated, but they are far more sensitive to pain relievers, especially opioids.
New research led by investigators at Massachusetts General Hospital provides insights on why people with red hair exhibit altered sensitivity to certain kinds of pain. The findings are published ...
Jun 26, 2024
Background: Age and body temperature alter inhalational anesthetic requirement; however, no human genotype is associated with inhalational anesthetic requirement. There is an anecdotal impression that anesthetic requirement is increased in redheads. ...
May 29, 2024
The higher pain tolerance observed in redheads may seem like a trivial trait, but it could have provided significant evolutionary advantages in the past. In times of injury or illness, redheads may have been able to endure pain for longer periods of time, allowing them to continue with necessary activities like hunting or gathering.
In the 2005 study using thermal pain, the researchers examined the effect of lidocaine in people with red and dark hair. Both groups had a similar response to lidocaine that was applied topically.
Nov 5, 2025
This could explain why redheads sometimes require different dosages of anesthesia or analgesics during medical procedures. Pain Sensitivity: What Research Reveals Scientific investigations into whether redheads have a higher or lower tolerance for pain have produced intriguing results.
The same gene that gives someone red hair may also lower their pain tolerance, some researchers posit. "Red hair is the only physical characteristic that indicates how much anesthetic a person needs," says anesthesia researcher Daniel Sessler, M.D. "Redheads report more pain during procedures.
A Massachusetts General Hospital study may have found why redheads have a different tolerance for pain.
Sep 22, 2025
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