In Autosomal Dominant Inheritance Asp Gal
🛑 ALL INFORMATION CLICK HERE 👈🏻👈🏻👈🏻
In Autosomal Dominant Inheritance Asp Gal
Dashboard
Publications
Account settings
Log out
Journal List
J Cell Biol
v.211(5); 2015 Dec 7
PMC4674283
J Cell Biol. 2015 Dec 7; 211(5): 987–998.
Cell Biology and Physiology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892
Correspondence to N.M. Rusan: vog.hin@ressaN
Received 2015 Sep 11; Accepted 2015 Oct 27.
This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms ). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/ ).
GUID: D2BB7CFD-8239-4CF6-B6D7-05CF74979442
GUID: FE48871C-07DD-4A0E-AC50-FDB0F81415CF
GUID: BFF366AB-4FA4-4FBF-BB73-062B44AEF5C7
GUID: E39F1E76-F61A-45C1-A855-00D635BEE9B8
GUID: EF6C1F25-29BE-45E3-B9BD-BF7AA307D93C
GUID: 5C8C1D88-3D36-4D53-9EFA-279E89C2FAEF
GUID: 1CF12124-7401-4C96-AC49-1DFEBD0807A7
GUID: 8BE6CCCA-C302-41DE-B91A-66EE39BFF05C
GUID: BB73F12A-AF09-452C-9968-FD91154C4344
GUID: FE6A2F51-0925-494F-B1D1-AEB53FD96B56
Abbreviations used in this paper: Asp abnormal spindle ASPM abnormal spindle-like microcephaly associated Df deficiency FL full length GMC ganglion mother cell MT microtubule NB neuroblast NuMA nuclear mitotic apparatus protein WT wild type
Basto R., Lau J., Vinogradova T., Gardiol A., Woods C.G., Khodjakov A., and Raff J.W..
2006.
Flies without centrioles . Cell.
125 :1375–1386. 10.1016/j.cell.2006.05.025 [ PubMed ] [ CrossRef ] [ Google Scholar ] Bond J., Roberts E., Mochida G.H., Hampshire D.J., Scott S., Askham J.M., Springell K., Mahadevan M., Crow Y.J., Markham A.F., et al..
2002.
ASPM is a major determinant of cerebral cortical size . Nat. Genet.
32 :316–320. 10.1038/ng995 [ PubMed ] [ CrossRef ] [ Google Scholar ] Bond J., Scott S., Hampshire D.J., Springell K., Corry P., Abramowicz M.J., Mochida G.H., Hennekam R.C.M., Maher E.R., Fryns J.-P., et al..
2003.
Protein-truncating mutations in ASPM cause variable reduction in brain size . Am. J. Hum. Genet.
73 :1170–1177. 10.1086/379085 [ PMC free article ] [ PubMed ] [ CrossRef ] [ Google Scholar ] Bowman S.K., Neumüller R.A., Novatchkova M., Du Q., and Knoblich J.A..
2006.
The Drosophila NuMA homolog mud regulates spindle orientation in asymmetric cell division . Dev. Cell.
10 :731–742. 10.1016/j.devcel.2006.05.005 [ PubMed ] [ CrossRef ] [ Google Scholar ] Carmena M., Gonzalez C., Casal J., and Ripoll P..
1991.
Dosage dependence of maternal contribution to somatic cell division in Drosophila melanogaster . Development.
113 :1357–1364. [ PubMed ] [ Google Scholar ] Castellanos E., Dominguez P., and Gonzalez C..
2008.
Centrosome dysfunction in Drosophila neural stem cells causes tumors that are not due to genome instability . Curr. Biol.
18 :1209–1214. 10.1016/j.cub.2008.07.029 [ PubMed ] [ CrossRef ] [ Google Scholar ] Conduit P.T., and Raff J.W..
2010.
Cnn dynamics drive centrosome size asymmetry to ensure daughter centriole retention in Drosophila neuroblasts . Curr. Biol.
20 :2187–2192. 10.1016/j.cub.2010.11.055 [ PubMed ] [ CrossRef ] [ Google Scholar ] Dionne M.A., Howard L., and Compton D.A..
1999.
NuMA is a component of an insoluble matrix at mitotic spindle poles . Cell Motil. Cytoskeleton.
42 :189–203. 10.1002/(SICI)1097-0169(1999)42:3<189::AID-CM3>3.0.CO;2-X [ PubMed ] [ CrossRef ] [ Google Scholar ] do Carmo Avides M., and Glover D.M..
1999.
Abnormal spindle protein, Asp, and the integrity of mitotic centrosomal microtubule organizing centers . Science.
283 :1733–1735. 10.1126/science.283.5408.1733 [ PubMed ] [ CrossRef ] [ Google Scholar ] Endow S.A., Chandra R., Komma D.J., Yamamoto A.H., and Salmon E.D..
1994.
Mutants of the Drosophila ncd microtubule motor protein cause centrosomal and spindle pole defects in mitosis . J. Cell Sci.
107 :859–867. [ PubMed ] [ Google Scholar ] Fish J.L., Kosodo Y., Enard W., Pääbo S., and Huttner W.B..
2006.
Aspm specifically maintains symmetric proliferative divisions of neuroepithelial cells . Proc. Natl. Acad. Sci. USA.
103 :10438–10443. 10.1073/pnas.0604066103 [ PMC free article ] [ PubMed ] [ CrossRef ] [ Google Scholar ] Franke J.D., Boury A.L., Gerald N.J., and Kiehart D.P..
2006.
Native nonmuscle myosin II stability and light chain binding in Drosophila melanogaster . Cell Motil. Cytoskeleton.
63 :604–622. 10.1002/cm.20148 [ PubMed ] [ CrossRef ] [ Google Scholar ] Gaglio T., Saredi A., Bingham J.B., Hasbani M.J., Gill S.R., Schroer T.A., and Compton D.A..
1996.
Opposing motor activities are required for the organization of the mammalian mitotic spindle pole . J. Cell Biol.
135 :399–414. 10.1083/jcb.135.2.399 [ PMC free article ] [ PubMed ] [ CrossRef ] [ Google Scholar ] Galletta B.J., and Rusan N.M..
2015.
A yeast two-hybrid approach for probing protein–protein interactions at the centrosome . In Methods in Cell Biology. Vol. 129
Renata B., and Karen O., editors. Academic Press, Amsterdam:
251–277. [ PMC free article ] [ PubMed ] [ Google Scholar ] Galletta B.J., Guillen R.X., Fagerstrom C.J., Brownlee C.W., Lerit D.A., Megraw T.L., Rogers G.C., and Rusan N.M..
2014.
Drosophila pericentrin requires interaction with calmodulin for its function at centrosomes and neuronal basal bodies but not at sperm basal bodies . Mol. Biol. Cell.
25 :2682–2694. 10.1091/mbc.E13-10-0617 [ PMC free article ] [ PubMed ] [ CrossRef ] [ Google Scholar ] Gonzalez C., Saunders R.D., Casal J., Molina I., Carmena M., Ripoll P., and Glover D.M..
1990.
Mutations at the asp locus of Drosophila lead to multiple free centrosomes in syncytial embryos, but restrict centrosome duplication in larval neuroblasts . J. Cell Sci.
96 :605–616. [ PubMed ] [ Google Scholar ] Goshima G., and Vale R.D..
2003.
The roles of microtubule-based motor proteins in mitosis: comprehensive RNAi analysis in the Drosophila S2 cell line . J. Cell Biol.
162 :1003–1016. 10.1083/jcb.200303022 [ PMC free article ] [ PubMed ] [ CrossRef ] [ Google Scholar ] Goshima G., Wollman R., Goodwin S.S., Zhang N., Scholey J.M., Vale R.D., and Stuurman N..
2007.
Genes required for mitotic spindle assembly in Drosophila S2 cells . Science.
316 :417–421. 10.1126/science.1141314 [ PMC free article ] [ PubMed ] [ CrossRef ] [ Google Scholar ] Harborth J., Wang J., Gueth-Hallonet C., Weber K., and Osborn M..
1999.
Self assembly of NuMA: multiarm oligomers as structural units of a nuclear lattice . EMBO J.
18 :1689–1700. 10.1093/emboj/18.6.1689 [ PMC free article ] [ PubMed ] [ CrossRef ] [ Google Scholar ] Januschke J., and Gonzalez C..
2010.
The interphase microtubule aster is a determinant of asymmetric division orientation in Drosophila neuroblasts . J. Cell Biol.
188 :693–706. 10.1083/jcb.200905024 [ PMC free article ] [ PubMed ] [ CrossRef ] [ Google Scholar ] Januschke J., Llamazares S., Reina J., and Gonzalez C..
2011.
Drosophila neuroblasts retain the daughter centrosome . Nat. Commun.
2 :243
10.1038/ncomms1245 [ PMC free article ] [ PubMed ] [ CrossRef ] [ Google Scholar ] Januschke J., Reina J., Llamazares S., Bertran T., Rossi F., Roig J., and Gonzalez C..
2013.
Centrobin controls mother-daughter centriole asymmetry in Drosophila neuroblasts . Nat. Cell Biol.
15 :241–248. 10.1038/ncb2671 [ PubMed ] [ CrossRef ] [ Google Scholar ] Kisurina-Evgenieva O., Mack G., Du Q., Macara I., Khodjakov A., and Compton D.A..
2004.
Multiple mechanisms regulate NuMA dynamics at spindle poles . J. Cell Sci.
117 :6391–6400. 10.1242/jcs.01568 [ PubMed ] [ CrossRef ] [ Google Scholar ] Lecland N., and Lüders J..
2014.
The dynamics of microtubule minus ends in the human mitotic spindle . Nat. Cell Biol.
16 :770–778. 10.1038/ncb2996 [ PubMed ] [ CrossRef ] [ Google Scholar ] Lecland N., Debec A., Delmas A., Moutinho-Pereira S., Malmanche N., Bouissou A., Dupré C., Jourdan A., Raynaud-Messina B., Maiato H., and Guichet A..
2013.
Establishment and mitotic characterization of new Drosophila acentriolar cell lines from DSas-4 mutant . Biol. Open.
2 :314–323. 10.1242/bio.20133327 [ PMC free article ] [ PubMed ] [ CrossRef ] [ Google Scholar ] Lerit D.A., and Rusan N.M..
2013.
PLP inhibits the activity of interphase centrosomes to ensure their proper segregation in stem cells . J. Cell Biol.
202 :1013–1022. 10.1083/jcb.201303141 [ PMC free article ] [ PubMed ] [ CrossRef ] [ Google Scholar ] Lerit D.A., Smyth J.T., and Rusan N.M..
2013.
Organelle asymmetry for proper fitness, function, and fate . Chromosome Res.
21 :271–286. 10.1007/s10577-013-9350-3 [ PMC free article ] [ PubMed ] [ CrossRef ] [ Google Scholar ] Lerit D.A., Plevock K.M., and Rusan N.M..
2014.
Live imaging of Drosophila larval neuroblasts . J. Vis. Exp.
89 :e5175
10.3791/51756 [ PMC free article ] [ PubMed ] [ CrossRef ] [ Google Scholar ] Mahjoub M.R., and Stearns T..
2012.
Supernumerary centrosomes nucleate extra cilia and compromise primary cilium signaling . Curr. Biol.
22 :1628–1634. 10.1016/j.cub.2012.06.057 [ PMC free article ] [ PubMed ] [ CrossRef ] [ Google Scholar ] Matos I., Pereira A.J., Lince-Faria M., Cameron L.A., Salmon E.D., and Maiato H..
2009.
Synchronizing chromosome segregation by flux-dependent force equalization at kinetochores . J. Cell Biol.
186 :11–26. 10.1083/jcb.200904153 [ PMC free article ] [ PubMed ] [ CrossRef ] [ Google Scholar ] Matthies H.J., McDonald H.B., Goldstein L.S., and Theurkauf W.E..
1996.
Anastral meiotic spindle morphogenesis: role of the non-claret disjunctional kinesin-like protein . J. Cell Biol.
134 :455–464. 10.1083/jcb.134.2.455 [ PMC free article ] [ PubMed ] [ CrossRef ] [ Google Scholar ] Meijering E., Dzyubachyk O., and Smal I..
2012.
Methods for cell and particle tracking . Methods Enzymol.
504 :183–200. 10.1016/B978-0-12-391857-4.00009-4 [ PubMed ] [ CrossRef ] [ Google Scholar ] Merdes A., Ramyar K., Vechio J.D., and Cleveland D.W..
1996.
A complex of NuMA and cytoplasmic dynein is essential for mitotic spindle assembly . Cell.
87 :447–458. 10.1016/S0092-8674(00)81365-3 [ PubMed ] [ CrossRef ] [ Google Scholar ] Merdes A., Heald R., Samejima K., Earnshaw W.C., and Cleveland D.W..
2000.
Formation of spindle poles by dynein/dynactin-dependent transport of NuMA . J. Cell Biol.
149 :851–862. 10.1083/jcb.149.4.851 [ PMC free article ] [ PubMed ] [ CrossRef ] [ Google Scholar ] Morales-Mulia S., and Scholey J.M..
2005.
Spindle pole organization in Drosophila S2 cells by dynein, abnormal spindle protein (Asp), and KLP10A . Mol. Biol. Cell.
16 :3176–3186. 10.1091/mbc.E04-12-1110 [ PMC free article ] [ PubMed ] [ CrossRef ] [ Google Scholar ] Morin X., Daneman R., Zavortink M., and Chia W..
2001.
A protein trap strategy to detect GFP-tagged proteins expressed from their endogenous loci in Drosophila . Proc. Natl. Acad. Sci. USA.
98 :15050–15055. 10.1073/pnas.261408198 [ PMC free article ] [ PubMed ] [ CrossRef ] [ Google Scholar ] Osawa M., Swindells M.B., Tanikawa J., Tanaka T., Mase T., Furuya T., and Ikura M..
1998.
Solution structure of calmodulin-W-7 complex: the basis of diversity in molecular recognition . J. Mol. Biol.
276 :165–176. 10.1006/jmbi.1997.1524 [ PubMed ] [ CrossRef ] [ Google Scholar ] Poulton J.S., Cuningham J.C., and Peifer M..
2014.
Acentrosomal Drosophila epithelial cells exhibit abnormal cell division, leading to cell death and compensatory proliferation . Dev. Cell.
30 :731–745. 10.1016/j.devcel.2014.08.007 [ PMC free article ] [ PubMed ] [ CrossRef ] [ Google Scholar ] Rath U., Rogers G.C., Tan D., Gomez-Ferreria M.A., Buster D.W., Sosa H.J., and Sharp D.J..
2009.
The Drosophila kinesin-13, KLP59D, impacts Pacman- and Flux-based chromosome movement . Mol. Biol. Cell.
20 :4696–4705. 10.1091/mbc.E09-07-0557 [ PMC free article ] [ PubMed ] [ CrossRef ] [ Google Scholar ] Rebollo E., Sampaio P., Januschke J., Llamazares S., Varmark H., and González C..
2007.
Functionally unequal centrosomes drive spindle orientation in asymmetrically dividing Drosophila neural stem cells . Dev. Cell.
12 :467–474. 10.1016/j.devcel.2007.01.021 [ PubMed ] [ CrossRef ] [ Google Scholar ] Riparbelli M.G., Callaini G., Glover D.M., and Avides Mdo.C..
2002.
A requirement for the abnormal spindle protein to organise microtubules of the central spindle for cytokinesis in Drosophila . J. Cell Sci.
115 :913–922. [ PubMed ] [ Google Scholar ] Ripoll P., Pimpinelli S., Valdivia M.M., and Avila J..
1985.
A cell division mutant of Drosophila with a functionally abnormal spindle . Cell.
41 :907–912. 10.1016/S0092-8674(85)80071-4 [ PubMed ] [ CrossRef ] [ Google Scholar ] Rossignol P., Collier S., Bush M., Shaw P., and Doonan J.H..
2007.
Arabidopsis POT1A interacts with TERT-V(I8), an N-terminal splicing variant of telomerase . J. Cell Sci.
120 :3678–3687. 10.1242/jcs.004119 [ PubMed ] [ CrossRef ] [ Google Scholar ] Rujano M.A., Sanchez-Pulido L., Pennetier C., le Dez G., and Basto R..
2013.
The microcephaly protein Asp regulates neuroepithelium morphogenesis by controlling the spatial distribution of myosin II . Nat. Cell Biol.
15 :1294–1306. 10.1038/ncb2858 [ PubMed ] [ CrossRef ] [ Google Scholar ] Rusan N.M., and Peifer M..
2007.
A role for a novel centrosome cycle in asymmetric cell division . J. Cell Biol.
177 :13–20. 10.1083/jcb.200612140 [ PMC free article ] [ PubMed ] [ CrossRef ] [ Google Scholar ] Saunders R.D., Avides M.C., Howard T., Gonzalez C., and Glover D.M..
1997.
The Drosophila gene abnormal spindle encodes a novel microtubule-associated protein that associates with the polar regions of the mitotic spindle . J. Cell Biol.
137 :881–890. 10.1083/jcb.137.4.881 [ PMC free article ] [ PubMed ] [ CrossRef ] [ Google Scholar ] Sawin K.E., LeGuellec K., Philippe M., and Mitchison T.J..
1992.
Mitotic spindle organization by a plus-end-directed microtubule motor . Nature.
359 :540–543. 10.1038/359540a0 [ PubMed ] [ CrossRef ] [ Google Scholar ] Schindelin J., Arganda-Carreras I., Frise E., Kaynig V., Longair M., Pietzsch T., Preibisch S., Rueden C., Saalfeld S., Schmid B., et al..
2012.
Fiji: an open-source platform for biological-image analysis . Nat. Methods.
9 :676–682. 10.1038/nmeth.2019 [ PMC free article ] [ PubMed ] [ CrossRef ] [ Google Scholar ] Siegrist S.E., and Doe C.Q..
2006.
Extrinsic cues orient the cell division axis in Drosophila embryonic neuroblasts . Development.
133 :529–536. 10.1242/dev.02211 [ PubMed ] [ CrossRef ] [ Google Scholar ] Sir J.-H., Pütz M., Daly O., Morrison C.G., Dunning M., Kilmartin J.V., and Gergely F..
2013.
Loss of centrioles causes chromosomal instability in vertebrate somatic cells . J. Cell Biol.
203 :747–756. 10.1083/jcb.201309038 [ PMC free article ] [ PubMed ] [ CrossRef ] [ Google Scholar ] Trammell M.A., Mahoney N.M., Agard D.A., and Vale R.D..
2008.
Mob4 plays a role in spindle focusing in Drosophila S2 cells . J. Cell Sci.
121 :1284–1292. 10.1242/jcs.017210 [ PMC free article ] [ PubMed ] [ CrossRef ] [ Google Scholar ] van der Voet M., Berends C.W.H., Perreault A., Nguyen-Ngoc T., Gönczy P., Vidal M., Boxem M., and van den Heuvel S..
2009.
NuMA-related LIN-5, ASPM-1, calmodulin and dynein promote meiotic spindle rotation independently of cortical LIN-5/GPR/Galpha . Nat. Cell Biol.
11 :269–277
(alpha)
10.1038/ncb1834 [ PubMed ] [ CrossRef ] [ Google Scholar ] Wakefield J.G., Bonaccorsi S., and Gatti M..
2001.
The Drosophila protein asp is involved in microtubule organization during spindle formation and cytokinesis . J. Cell Biol.
153 :637–648. 10.1083/jcb.153.4.637 [ PMC free article ] [ PubMed ] [ CrossRef ] [ Google Scholar ] Walczak C.E., and Heald R..
2008.
Mechanisms of mitotic spindle assembly and function . In International Review of Cytology. Vol. 265
Kwang W.J., editor. Academic Press, Amsterdam:
111–158. [ PubMed ] [ Google Scholar ] Welsh M.J., Dedman J.R., Brinkley B.R., and Means A.R..
1978.
Calcium-dependent regulator protein: localization in mitotic apparatus of eukaryotic cells . Proc. Natl. Acad. Sci. USA.
75 :1867–1871. 10.1073/pnas.75.4.1867 [ PMC free article ] [ PubMed ] [ CrossRef ] [ Google Scholar ] Xu X.-L., Ma W., Zhu Y.-B., Wang C., Wang B.-Y., An N., An L., Liu Y., Wu Z.-H., and Tian J.-H..
2012.
The microtubule-associated protein ASPM regulates spindle assembly and meiotic progression in mouse oocytes . PLoS One.
7 :e49303
10.1371/journal.pone.0049303 [ PMC free article ] [ PubMed ] [ CrossRef ] [ Google Scholar ]
Articles from The Journal of Cell Biology are provided here courtesy of The Rockefeller University Press
Walczak C.E., and Heald R..
2008.
Mechanisms of mitotic spindle assembly and function . In International Review of Cytology. Vol. 265
Kwang W.J., editor. Academic Press, Amsterdam:
111–158. [ PubMed ] [ Google Scholar ] [ Ref list ]
Goshima G., and Vale R.D..
2003.
The roles of microtubule-based motor proteins in mitosis: comprehensive RNAi analysis in the Drosophila S2 cell line . J. Cell Biol.
162 :1003–1016. 10.1083/jcb.200303022 [ PMC free article ] [ PubMed ] [ CrossRef ] [ Google Scholar ] [ Ref list ]
Goshima G., Wollman R., Goodwin S.S., Zhang N., Scholey J.M., Vale R.D., and Stuurman N..
2007.
Genes required for mitotic spindle assembly in Drosophila S2 cells . Science.
316 :417–421. 10.1126/science.1141314 [ PMC free article ] [ PubMed ] [ CrossRef ] [ Google Scholar ] [ Ref list ]
Sawin K.E., LeGuellec K., Philippe M., and Mitchison T.J..
1992.
Mitotic spindle organization by a plus-end-directed microtubule motor . Nature.
359 :540–543. 10.1038/359540a0 [ PubMed ] [ CrossRef ] [ Google Scholar ] [ Ref list ]
Endow S.A., Chandra R., Komma D.J., Yamamoto A.H., and Salmon E.D..
1994.
Mutants of the Drosophila ncd microtubule motor protein cause centrosomal and spindle pole defects in mitosis . J. Cell Sci.
107 :859–867. [ PubMed ] [ Google Scholar ] [ Ref list ]
Gaglio T., Saredi A., Bingham J.B., Hasbani M.J., Gill S.R., Schroer T.A., and Compton D.A..
1996.
Opposing motor activities are required for the organization of the mammalian mitotic spindle pole . J. Cell Biol.
135 :399–414. 10.1083/jcb.135.2.399 [ PMC free article ] [ PubMed ] [ CrossRef ] [ Google Scholar ] [ Ref list ]
Matthies H.J., McDonald H.B., Goldstein L.S., and Theurkauf W.E..
1996.
Anastral meiotic spindle morphogenesis: role of the non-claret disjunctional kinesin-like protein . J. Cell Biol.
134 :455–464. 10.1083/jcb.134.2.455 [ PMC free article ] [ PubMed ] [ CrossRef ] [ Google Scholar ] [ Ref list ]
Merdes A., Ramyar K., Vechio J.D., and Cleveland D.W..
1996.
A complex of NuMA and cytoplasmic dynein is essential for mitotic spindle assembly . Cell.
87 :447–458. 10.1016/S0092-8674(00)81365-3 [ PubMed ] [ CrossRef ] [ Google Scholar ] [ Ref list ]
Harborth J., Wang J., Gueth-Hallonet C., Weber K., and Osborn M..
1999.
Porn Pic Video
Milf Sex Young
Celebrity Sex Real