🍒 Hypoxiainduced signaling in the cardiovascular system 💞

HypoxiaDriven Effects in Cancer Characterization

The Intriguing Role of Hypoxia Inducible Factor in Myocardial

Hypoxia signaling in cancer Implications for therapeutic

Nature Reviews Nephrology Volume 15 Issue 10 October 2019

Targeting hypoxia inducible factor 1 HIF1 signaling with

PDF Hypoxia signaling in human health and diseases

Hypoxia a key regulator of angiogenesis and inflammation in

Mechanisms of hypoxia signalling new implications for

Mechanisms of hypoxia signalling new implications for

Kidneys control interorgan homeostasis PMC

Hypoxia signaling in cancer Implications for therapeutic

Nobel Prize in Physiology or Medicine 2019 Nature

Hypoxia signaling in human diseases and therapeutic targets


7 oct. 2019 · Mechanisms of hypoxia signalling: new implications for nephrology Therapeutic modulation of hypoxia-inducible factors, which transduce adaptive transcriptional responses to hypoxia, is an emerging. 1 août 2024 · On the other hand, other studies provided evidence that normalization of blood vessels by PHD inhibition hampers tumor cell invasion and metastasis. 109 Therefore, identification of hypoxia-associated biomarkers and more detailed understanding of molecular mechanisms affected by hypoxia in certain types of diseases are helpful for designing and choosing specific therapeutic strategy. 15 déc. 2024 · Hypoxia is a condition frequently encountered by cells in tissues, whether as a normal feature of their microenvironment or subsequent to deregulated growth. Hypoxia can lead to acidification and. 31 janv. 2024 · The role of inflammation in rheumatoid arthritis (RA) is well characterized, but how hypoxia affects RA and the potential interplay between inflammation, angiogenesis and hypoxia in this disease. In this Review, we summarize information on the molecular circuitry of hypoxia signalling pathways underlying these new treatments and highlight some of the outstanding questions relevant to their clinical use. 中文翻译：. 低氧信号传导机制：对肾脏病的新影响。. 肝脏和肾脏对促红细胞生成素（EPO）产生的. 30 juil. 2024 · Rapisarda A, Uranchimeg B, Sordet O, Pommier Y, Shoemaker RH, Melillo G. Topoisomerase I-mediated inhibition of hypoxia-inducible factor 1: mechanism and therapeutic implications. Cancer Res. 2004. 14 févr. 2024 · Fig. 1. Kidneys control organ homeostasis. Kidney injury can induce the production of anorexic and muscle-wasting signals from various cell populations, resulting in cachexia. Injured kidney cells can induce profound effects beyond their regular microenvironments showcasing the kidney as an active participant in complex inter-organ signalling. 14 mai 2024 · Short-term adaptive mechanisms focus on ATP production under hypoxic conditions, while long-term mechanisms, such as angiogenesis, act in chronic ischemic conditions. Investigating the molecular mechanisms behind HIF activation, function, and their downstream pathways in the context of myocardial ischemia and reperfusion injury can provide valuable insights for therapeutic development. 5 sept. 2019 · Nature Reviews Nephrology - Therapeutic modulation of hypoxia-inducible factors, which transduce adaptive transcriptional responses to hypoxia, is an emerging theme in kidney disease. This. 5 sept. 2019 · Studies of the regulation of erythropoietin (EPO) production by the liver and kidneys, one of the classical physiological responses to hypoxia, led to the discovery of human oxygen-sensing mechanisms, which are now being targeted therapeutically. The oxygen-sensitive signal is generated by 2-oxoglutarate-dependent dioxygenases that. 5 sept. 2019 · Request PDF | Mechanisms of hypoxia signalling: new implications for nephrology | Studies of the regulation of erythropoietin (EPO) production by the liver and kidneys, one of the classical. This review outlined the characteristics of oxygen supply in the kidney, changes in oxygen metabolism and factors leading to hypoxia in CKD. Mechanistically, we discussed how hypoxia contributes to renal injury as well as complications associated with CKD. 8 août 2019 · Reviews on hypoxia signalling, acute tubular injury subtypes, kidney organoids and the immunology of ageing, plus commentaries on increasing diversity in STEM, kidney metabolism and. 5 sept. 2019 · Mechanisms of hypoxia signalling: new implications for nephrology Introduction. Most organisms use oxygen to fuel cellular respiration and for other vital functions and, therefore, HIF transcription factors. Human HIF-1 was discovered as a protein complex binding to a regulatory DNA sequence at. 7 juil. 2024 · This paper systematically reviews the mechanisms of hypoxia signaling activation, the control of HIF signaling, and the function of HIF signaling in human health and diseases. In addition, the therapeutic targets involved in HIF signaling to balance health and diseases are summarized and highlighted, which would provide novel. 20 nov. 2024 · HIFs are central molecules in the hypoxic response. 1 Due to the intricate interplay between oxygen and internal/external environmental factors, the roles played by different HIF isoforms can vary. 7 juil. 2024 · Hypoxia-inducible factors (HIFs) sense hypoxia to regulate the expressions of a series of downstream genes expression, which participate in multiple processes including cell metabolism, cell. 7 juil. 2024 · This paper systematically reviews the mechanisms of hypoxia signaling activation, the control of HIF signaling, and the function of HIF signaling in human health and diseases. In addition, the therapeutic targets involved in HIF signaling to balance health and diseases are summarized and highlighted, which would provide novel strategies for the. 20 juin 2019 · In this review, we will discuss the current understandings of hypoxia signaling in human diseases by the organ systems, including the heart, lung, liver, and kidney. We will also discuss. 20 juin 2019 · Hypoxia can result from any failure that might happen during this process, which encompasses failure of the respiratory system, insufficient blood flow to an end organ, dysfunctional or low levels of hemoglobin, or chemically induced hypoxia. 20 juin 2019 · Since the discovery of hypoxia-inducible factor (HIF), numerous studies on the hypoxia signaling pathway have been performed. The role of HIF stabilization during hypoxia has been extended from the induction of a single gene erythropoietin to the upregulation of a couple of hundred downstream target . Ensure Credible & Reproducible Results With CST's Validated Antibodies & Assays. Dedicated to providing the world’s highest quality, innovative research products. 23 janv. 2024 · A hypoxic tumor microenvironment (TME) can reduce the effectiveness of other tumor therapies, such as radiotherapy, chemotherapy, and immunotherapy. In this review, we discuss the critical role of hypoxia in tumor development, including tumor metabolism, tumor immunity, and tumor angiogenesis. 23 janv. 2024 · Hypoxia occurs in the majority of solid tumors due to a poor vascular oxygen supply that is not sufficient to meet the needs of rapidly proliferating cancer cells. A hypoxic tumor microenvironment (TME) can reduce the effectiveness of other tumor therapies, such as radiotherapy, chemotherapy, and immunotherapy. 1 févr. 2024 · Hypoxia is a persistent physiological feature of many different solid tumors and a key driver of malignancy, and in recent years, it has been recognized as an important target for cancer therapy. 19 mars 2024 · The following review will highlight current knowledge on the effects of hypoxia on mutagenesis, DNA repair mechanisms, metastasis, the stem cell phenotype, and resistance to therapies in the context of cancer. In addition, the hypoxia-mediated drivers of cancer malignancy including HIFs and the unfolded protein response (UPR) will be summarized. Hypoxia can provide energy to tumor cells by activat-ingtranscriptionalprogramsthatinduceglucoseuptake andglycolysis.46,47 Tumorcellsadaptivelyturntoandro-gen/androgenreceptor-independentpathwaystosurvive and grow, resulting in therapeutic resistance.48 This is mediatedbyglucose-6-phosphateisomerase(GPI),which.