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WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section. It is not a recommendation and should be verified with other sources for accuracy. Cocaine also known as benzoylmethylecgonine , and informally as coke , cola , snow , blow , white , among others is a classical stimulant substance of the tropane class. It is a naturally-occurring alkaloid extracted from the leaves of the coca plant Erythroxylum coca. Cocaine is one of the most widespread and highly controlled illicit substances in the world. According to a United Nations report, it was the second most widely used substance in the world, after cannabis. Subjective effects include stimulation , increased blood pressure , appetite suppression , disinhibition , motivation enhancement , ego inflation , increased libido , and euphoria. Routes of administration include insufflation 'snorting' or 'sniffing' and occasionally injection. Oral intake is rare but possible. The typical cocaine high is characterized by a rapid onset and a short duration, featuring a powerful euphoric 'rush' that is followed by a marked comedown or 'crash' — an experience that can promote compulsive redosing. Excessive use is reported to increase the risk of anxiety , paranoia , minor hallucinations , mania , and, in rare cases, psychosis. It is known to have high abuse potential. Additionally, some evidence suggests it poses unique cardiotoxic risks compared to other CNS stimulants, including the entire amphetamine class. It is highly advised to use harm reduction practices if using this substance. This History and culture section is a stub. As a result, it may contain incomplete or wrong information. You can help by expanding it. A year-old collection of drug paraphernalia found in a rock shelter in Bolivia features traces of five psychoactive chemicals, including cocaine and components of ayahuasca. According to a United Nations report, cocaine is the second most widely used illicit substance in the world, after cannabis. In terms of user rates, Spain is the country with the highest rate of cocaine usage 3. Other countries where the usage rate meets or exceeds 1. The name cocaine is derived from 'coca' and the alkaloid suffix '-ine'. Cocaine has numerous common or street names, including coke , coca , cola , snow , ski , blow , nose candy , white , and girl. Spanish-influenced names include lello , yayo , yeyo , or yay. Cocaine is a tropane alkaloid found in the leaves of the coca plant, Erythroxylum coca. It is most commonly consumed as the hydrochloride salt which is typically produced in clandestine laboratories. Cocaine decomposes when heated strongly so the freebase and hydrogen carbonate salts of cocaine, which have much lower boiling points compared to the hydrochloride salt, are typically used when the substance is to be vaporized and are known as cocaine base and 'crack' respectively. The chemical structure of cocaine consists of three parts; the hydrophilic methyl ester moiety and the lipophilic benzoyl ester moiety, which are located in place of the carboxylic acid and hydroxyl groups of ecgonine respectively. This structure allows for its rapid absorption through nasal membranes and blood-brain barrier. The presence of the two ester groups makes cocaine relatively unstable in warm, humid environments and cocaine stored in an open container or with a high moisture content will lose apparent potency over time due to hydrolysis to methyl ecgonine or benzoylecgonine. The most extensively studied effect of cocaine on the central nervous system is the blockade of the dopamine transporter. This substance acts as a reuptake inhibitor and prevents dopamine from being recycled, causing excessive amounts to build up in the synapse, or junction between neurons. The result is an enhanced and prolonged post-synaptic effect of dopaminergic signaling. To a lesser extent, cocaine also exhibits functionally similar effects of reuptake inhibition upon the neurotransmitters of serotonin and noradrenaline. The most extensively studied effect of cocaine on the central nervous system is the blockade of the dopamine transporter protein. Dopamine transmitter released during neural signaling is normally recycled via the transporter; i. Cocaine binds tightly at the dopamine transporter forming a complex that blocks the transporter's function. The dopamine transporter can no longer perform its reuptake function, and thus dopamine accumulates in the synaptic cleft. The increased concentration of dopamine in the synapse activates post-synaptic dopamine receptors, which makes the drug rewarding and promotes the compulsive use of cocaine. Disclaimer: The effects listed below cite the Subjective Effect Index SEI , an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism. It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. The cognitive effects of cocaine can be broken down into several components which progressively intensify proportional to dosage. The general headspace of cocaine is described as one of extreme mental stimulation, increased motivation, and overwhelming euphoria. There are currently no anecdotal reports which describe the effects of this compound within our experience index. Additional experience reports can be found here:. Cocaine is often adulterated when sold on black markets and this can significantly alter its effects on the body. Even when adulterants are pharmacologically inactive, their combination with the long-term perishability of cocaine due to moisture can lead to vastly differing apparent potencies between dosages of cocaine, and as such, it can be challenging to determine a 'typical' recreational dose. Pure cocaine is very potent and generates perceptible local anesthetic effects from 1 mg and perceptible CNS stimulation from mg; however, much higher doses tend to be used in recreational settings. Smoking or vaporizing cocaine and inhaling it into the lungs produces an almost immediate 'high' that can be very powerful and addictive. This initial buildup of stimulation is known as a 'rush'. While the stimulating effects may last for hours, the euphoric sensation is very brief, prompting the user to smoke more immediately. This toxicity and harm potential section is a stub. As a result, it may contain incomplete or even dangerously wrong information! You can help by expanding upon or correcting it. Note: Always conduct independent research and use harm reduction practices if using this substance. In terms of neurotoxicity as defined by the damage or death of cells in the brain in response to over-excitation or reactive oxidation caused by drugs , cocaine does not appear to exhibit these effects unlike certain other substances such as methamphetamine. Its extended use or abuse does, however, cause short-term downregulation of neurotransmitters. The most potentially harmful physical effects of cocaine appear to be not neurological but cardiovascular. Severe cardiac adverse events, particularly sudden cardiac death, become a serious risk at high doses due to cocaine's blocking effect on cardiac sodium channels. Regular cocaine insufflation, the most popular method of ingestion, can have extremely adverse effects on one's nostrils, nose, and nasal cavities. These include a loss of the sense of smell, nosebleeds, difficulty swallowing, hoarseness, or a chronically runny nose. It is strongly recommended that one use harm reduction practices if using this substance. Susceptible individuals have died from as little as 30 mg applied to mucous membranes, whereas addicts may tolerate up to 5 grams daily. As with other stimulants , the chronic use of cocaine can be considered highly addictive with a high potential for abuse and is capable of causing psychological dependence among certain users. When addiction has developed, cravings and withdrawal effects may occur if a person suddenly stops their usage. Addiction is a serious risk with heavy recreational cocaine use but is unlikely to arise from typical medical use. Tolerance to many of the effects of cocaine develops with prolonged and repeated use. This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about 3 - 7 days for the tolerance to be reduced to half and 1 - 2 weeks to be back at baseline in the absence of further consumption. Cocaine exhibits cross-tolerance with all dopaminergic stimulants , meaning that after the consumption of cocaine all stimulants will have a reduced effect. After taking cocaine on a regular basis, some users will become addicted. When the substance is discontinued immediately, the user will experience what has come to be known as a 'crash' along with a number of other cocaine withdrawal symptoms including paranoia , depression , anxiety , itching, mood swings , irritability , fatigue, insomnia , an intense craving for more cocaine, and, in some cases, nausea and vomiting. These symptoms can last for weeks or, in some cases, months. Even after most withdrawal symptoms dissipate most users feel the need to continue using the drug; this feeling can last for years and may peak during times of stress. Cocaine has a similar potential to induce temporary psychosis \\\\\\\[20\\\\\\\] with more than half of cocaine abusers reporting at least some psychotic symptoms at some point. Typical symptoms of sufferers include paranoid delusions that they are being followed and that their drug use is being watched accompanied by hallucinations that support the delusional beliefs. Cocaine-induced psychosis shows sensitization toward the psychotic effects of the drug. This means that psychosis becomes more severe with repeated intermittent use. Warning: Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions although it is not guaranteed to include all of them. Always conduct independent research e. Google , DuckDuckGo , PubMed to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit. From PsychonautWiki. Summary sheet: Cocaine Cocaine. Physical effects. Cognitive effects. After effects. Main article: Stimulant psychosis. March Journal of Ethnopharmacology. ISSN April Narcotic Drugs. National Book Trust. ISBN Clinical Pharmacology and Therapeutics. Journal of Analytical Toxicology. The Lancet. British Journal of Clinical Pharmacology. Proceedings of the National Academy of Sciences. CO; 'Amphetamine-type central nervous system stimulants release norepinephrine more potently than they release dopamine and serotonin'. Journal of Cellular Physiology. The American Journal on Addictions. December The Journal of Clinical Psychiatry. October Psychiatric Services. Government of Austria. Retrieved February 18, Reichsministerium des Innern. Retrieved December 28, Retrieved December 19, Strafsenat des Bundesgerichtshofs. February 1, Bundeskanzlei \\\\\\\[Federal Chancellery of Switzerland\\\\\\\]. Retrieved January 1, Hidden categories: CS1 German-language sources de All articles with unsourced statements Articles with unsourced statements. Navigation menu Personal tools Create account Log in. Namespaces Page Discussion. Views Read View source View history. Yolo Donate. Donate Contact us Guidelines Recent changes Open source. Network Good vibes Bad vibes. Tropane alkaloid.
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WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section. It is not a recommendation and should be verified with other sources for accuracy. Cocaine also known as benzoylmethylecgonine , and informally as coke , cola , snow , blow , white , among others is a classical stimulant substance of the tropane class. It is a naturally-occurring alkaloid extracted from the leaves of the coca plant Erythroxylum coca. Cocaine is one of the most widespread and highly controlled illicit substances in the world. According to a United Nations report, it was the second most widely used substance in the world, after cannabis. Subjective effects include stimulation , increased blood pressure , appetite suppression , disinhibition , motivation enhancement , ego inflation , increased libido , and euphoria. Routes of administration include insufflation 'snorting' or 'sniffing' and occasionally injection. Oral intake is rare but possible. The typical cocaine high is characterized by a rapid onset and a short duration, featuring a powerful euphoric 'rush' that is followed by a marked comedown or 'crash' — an experience that can promote compulsive redosing. Excessive use is reported to increase the risk of anxiety , paranoia , minor hallucinations , mania , and, in rare cases, psychosis. It is known to have high abuse potential. Additionally, some evidence suggests it poses unique cardiotoxic risks compared to other CNS stimulants, including the entire amphetamine class. It is highly advised to use harm reduction practices if using this substance. This History and culture section is a stub. As a result, it may contain incomplete or wrong information. You can help by expanding it. A year-old collection of drug paraphernalia found in a rock shelter in Bolivia features traces of five psychoactive chemicals, including cocaine and components of ayahuasca. According to a United Nations report, cocaine is the second most widely used illicit substance in the world, after cannabis. In terms of user rates, Spain is the country with the highest rate of cocaine usage 3. Other countries where the usage rate meets or exceeds 1. The name cocaine is derived from 'coca' and the alkaloid suffix '-ine'. Cocaine has numerous common or street names, including coke , coca , cola , snow , ski , blow , nose candy , white , and girl. Spanish-influenced names include lello , yayo , yeyo , or yay. Cocaine is a tropane alkaloid found in the leaves of the coca plant, Erythroxylum coca. It is most commonly consumed as the hydrochloride salt which is typically produced in clandestine laboratories. Cocaine decomposes when heated strongly so the freebase and hydrogen carbonate salts of cocaine, which have much lower boiling points compared to the hydrochloride salt, are typically used when the substance is to be vaporized and are known as cocaine base and 'crack' respectively. The chemical structure of cocaine consists of three parts; the hydrophilic methyl ester moiety and the lipophilic benzoyl ester moiety, which are located in place of the carboxylic acid and hydroxyl groups of ecgonine respectively. This structure allows for its rapid absorption through nasal membranes and blood-brain barrier. The presence of the two ester groups makes cocaine relatively unstable in warm, humid environments and cocaine stored in an open container or with a high moisture content will lose apparent potency over time due to hydrolysis to methyl ecgonine or benzoylecgonine. The most extensively studied effect of cocaine on the central nervous system is the blockade of the dopamine transporter. This substance acts as a reuptake inhibitor and prevents dopamine from being recycled, causing excessive amounts to build up in the synapse, or junction between neurons. The result is an enhanced and prolonged post-synaptic effect of dopaminergic signaling. To a lesser extent, cocaine also exhibits functionally similar effects of reuptake inhibition upon the neurotransmitters of serotonin and noradrenaline. The most extensively studied effect of cocaine on the central nervous system is the blockade of the dopamine transporter protein. Dopamine transmitter released during neural signaling is normally recycled via the transporter; i. Cocaine binds tightly at the dopamine transporter forming a complex that blocks the transporter's function. The dopamine transporter can no longer perform its reuptake function, and thus dopamine accumulates in the synaptic cleft. The increased concentration of dopamine in the synapse activates post-synaptic dopamine receptors, which makes the drug rewarding and promotes the compulsive use of cocaine. Disclaimer: The effects listed below cite the Subjective Effect Index SEI , an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism. It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. The cognitive effects of cocaine can be broken down into several components which progressively intensify proportional to dosage. The general headspace of cocaine is described as one of extreme mental stimulation, increased motivation, and overwhelming euphoria. There are currently no anecdotal reports which describe the effects of this compound within our experience index. Additional experience reports can be found here:. Cocaine is often adulterated when sold on black markets and this can significantly alter its effects on the body. Even when adulterants are pharmacologically inactive, their combination with the long-term perishability of cocaine due to moisture can lead to vastly differing apparent potencies between dosages of cocaine, and as such, it can be challenging to determine a 'typical' recreational dose. Pure cocaine is very potent and generates perceptible local anesthetic effects from 1 mg and perceptible CNS stimulation from mg; however, much higher doses tend to be used in recreational settings. Smoking or vaporizing cocaine and inhaling it into the lungs produces an almost immediate 'high' that can be very powerful and addictive. This initial buildup of stimulation is known as a 'rush'. While the stimulating effects may last for hours, the euphoric sensation is very brief, prompting the user to smoke more immediately. This toxicity and harm potential section is a stub. As a result, it may contain incomplete or even dangerously wrong information! You can help by expanding upon or correcting it. Note: Always conduct independent research and use harm reduction practices if using this substance. In terms of neurotoxicity as defined by the damage or death of cells in the brain in response to over-excitation or reactive oxidation caused by drugs , cocaine does not appear to exhibit these effects unlike certain other substances such as methamphetamine. Its extended use or abuse does, however, cause short-term downregulation of neurotransmitters. The most potentially harmful physical effects of cocaine appear to be not neurological but cardiovascular. Severe cardiac adverse events, particularly sudden cardiac death, become a serious risk at high doses due to cocaine's blocking effect on cardiac sodium channels. Regular cocaine insufflation, the most popular method of ingestion, can have extremely adverse effects on one's nostrils, nose, and nasal cavities. These include a loss of the sense of smell, nosebleeds, difficulty swallowing, hoarseness, or a chronically runny nose. It is strongly recommended that one use harm reduction practices if using this substance. Susceptible individuals have died from as little as 30 mg applied to mucous membranes, whereas addicts may tolerate up to 5 grams daily. As with other stimulants , the chronic use of cocaine can be considered highly addictive with a high potential for abuse and is capable of causing psychological dependence among certain users. When addiction has developed, cravings and withdrawal effects may occur if a person suddenly stops their usage. Addiction is a serious risk with heavy recreational cocaine use but is unlikely to arise from typical medical use. Tolerance to many of the effects of cocaine develops with prolonged and repeated use. This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about 3 - 7 days for the tolerance to be reduced to half and 1 - 2 weeks to be back at baseline in the absence of further consumption. Cocaine exhibits cross-tolerance with all dopaminergic stimulants , meaning that after the consumption of cocaine all stimulants will have a reduced effect. After taking cocaine on a regular basis, some users will become addicted. When the substance is discontinued immediately, the user will experience what has come to be known as a 'crash' along with a number of other cocaine withdrawal symptoms including paranoia , depression , anxiety , itching, mood swings , irritability , fatigue, insomnia , an intense craving for more cocaine, and, in some cases, nausea and vomiting. These symptoms can last for weeks or, in some cases, months. Even after most withdrawal symptoms dissipate most users feel the need to continue using the drug; this feeling can last for years and may peak during times of stress. Cocaine has a similar potential to induce temporary psychosis \\\\\\\\\\\[20\\\\\\\\\\\] with more than half of cocaine abusers reporting at least some psychotic symptoms at some point. Typical symptoms of sufferers include paranoid delusions that they are being followed and that their drug use is being watched accompanied by hallucinations that support the delusional beliefs. Cocaine-induced psychosis shows sensitization toward the psychotic effects of the drug. This means that psychosis becomes more severe with repeated intermittent use. Warning: Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions although it is not guaranteed to include all of them. Always conduct independent research e. Google , DuckDuckGo , PubMed to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit. From PsychonautWiki. Summary sheet: Cocaine Cocaine. Physical effects. Cognitive effects. After effects. Main article: Stimulant psychosis. March Journal of Ethnopharmacology. ISSN April Narcotic Drugs. National Book Trust. ISBN Clinical Pharmacology and Therapeutics. Journal of Analytical Toxicology. The Lancet. British Journal of Clinical Pharmacology. Proceedings of the National Academy of Sciences. CO; 'Amphetamine-type central nervous system stimulants release norepinephrine more potently than they release dopamine and serotonin'. Journal of Cellular Physiology. The American Journal on Addictions. December The Journal of Clinical Psychiatry. October Psychiatric Services. Government of Austria. Retrieved February 18, Reichsministerium des Innern. Retrieved December 28, Retrieved December 19, Strafsenat des Bundesgerichtshofs. February 1, Bundeskanzlei \\\\\\\\\\\[Federal Chancellery of Switzerland\\\\\\\\\\\]. Retrieved January 1, Hidden categories: CS1 German-language sources de All articles with unsourced statements Articles with unsourced statements. Navigation menu Personal tools Create account Log in. Namespaces Page Discussion. Views Read View source View history. Yolo Donate. Donate Contact us Guidelines Recent changes Open source. Network Good vibes Bad vibes. Tropane alkaloid.