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✅ Мефедрон: что это, эффект, действие, последствия | Мефедроновая зависимость
Reading, engaging with, and sharing our publications, papers and commentary gives evidence-based science and policy the audience it needs and deserves. By checking this box I consent to the use of my information provided for email marketing purposes. Mephedrone 4-methylmethcathinone is a former legal-high that is now banned across the EU. It is a manufactured substance rather than natural substance. It appears as a white or off-white powder which is primarily either snorted or swallowed. Injection has also been reported. Injection of drugs is associated with higher risks of overdose and other harms like infection. Mephedrone is a stimulant and its effects are reported to be similar in some ways to cocaine and MDMA. As mephedrone has only been widely used from around onwards, not much has been established scientifically about the specific effects of the drug. People who have used mephedrone report stimulant effects such as increased energy, self-confidence and talkativeness. When mephedrone is snorted, it only takes a few minutes for its effects to appear, and the effects generally peak in half an hour or less. When swallowed usually wrapped in a cigarette paper its effects can take more than 45 minutes to appear, depending on factors like how much food is in the stomach. People using the drug also report a comedown period after use, which can also be compared to the comedown periods experienced after cocaine , speed or MDMA use. Users have reported that it is very tempting to take more mephedrone again and again to keep the high going and to prevent the comedown. This increases the risks of immediate harm and may increase the risk of becoming addicted. Much of the information in this section was taken from Schifano et al, There have been deaths associated with or caused by mephedrone use , although not as many as were reported in the media. Usually, deaths involved very high doses, mephedrone use with alcohol and other drugs including interacting prescription drugs or pre-existing problems such as heart or liver conditions. Mephedrone deaths and serious emergencies occur in a similar way to deaths from other strong stimulants. The drug effects can overload the heart, and overheating can cause seizures and organ failure. Fatal accidents have also been associated with the drug. It should always be treated as a medical emergency if someone collapses having taken mephedrone, suffers seizures, or sudden chest pains. Other much more common nasty effects, usually associated with moderate or high doses, include feeling unbearably hot, feeling faint or that your heart is racing uncomfortably fast. Some people suffer paranoia, frightening hallucinations, confusion, panic and agitation. If you or a friend gets these symptoms, stay as calm as you can, move if necessary to a more relaxed, cooler environment and try to calm down. Lying down may be helpful, taking slow breaths, breathing in and out of a paper bag helps with panic. If it does help and you feel totally recovered, it is still sensible not to get back into the party and take more mephedrone. Some people have binged on mephedrone for several days. Eating, drinking, sleeping and resting are vital. Missing these things makes someone more likely to suffer from any of the potential harms, from the slightly unpleasant effects to seizures, psychosis and death. As with other stimulants such as speed or cocaine , taking mephedrone if you have a heart problem or high blood-pressure is likely to be riskier. Mental health should be taken into account, as the chance of panic, paranoia, hallucinations and compulsive bingeing are likely to be increased if you have a disorder that predisposes you to these. The risks of harm, including death, are likely to be increased by taking the drug whilst being on prescribed medication especially antidepressants or particularly taking other stimulant drugs such as amphetamines, MDMA and cocaine. Not enough is currently known about mephedrone to say how harmful use would be over a long period of time. It is probable that the long term harms of mephedrone would be similar to drugs such as cocaine and MDMA due to their similar effects and structure. There is also some suggestion that mephedrone could be quite addictive, with cravings and low mood unless the drug is taken. However, there has not yet been enough rigorous scientific investigation into mephedrone addiction. Mephedrone harm reduction advice is partly based on what we know of related drugs like amphetamines and MDMA, as not enough research has been done on mephedrone specifically. If you are dancing also you may overheat and become dehydrated. It is therefore a good idea to take regular breaks from dancing and drink moderate amounts of water. Before mephedrone was made illegal, people would sell mephedrone as plant fertilizer, bath salts or as a research chemical. This was a disguise for selling it for use as a recreational drug, to get around the law. Drug Science is an independent, science-led drugs charity. We rely on donations to continue to promote evidence-based information about drugs without political or commercial interference. We are grateful … But we need more. Becoming a donor will help ensure we can continue our work. Join our Community and access opportunities to become more deeply engaged in our work. Search for:. Keep up with developments in drug science Reading, engaging with, and sharing our publications, papers and commentary gives evidence-based science and policy the audience it needs and deserves. Home Mephedrone Meow Meow. Mephedrone Meow Meow. Previous: MDMA. Module: Psilocybin Science. Next: Modafinil. What is mephedrone? What are the different forms of mephedrone? How does mephedrone work as a drug in the body and brain? What are the effects of mephedrone? Does mephedrone have any medical uses? None known. What are the risks of using mephedrone? Are there health conditions that make mephedrone more dangerous? Mixing mephedrone with other drugs. What are the long-term effects of mephedrone on health and wellbeing? Mephedrone harm reduction advice. Mephedrone myths and misunderstandings. Is it actually plant food or bath salts? Related Content. December 1 Would you let your teenager try psychedelics? November 15 Where are we now? November 14 November 10 Support our work and help ensure that evidence-based research can influence policy and public opinion, not political or commercial agenda.
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Mephedrone , also known as 4-methylmethcathinone , 4-MMC , and 4-methylephedrone , is a synthetic stimulant drug of the amphetamine and cathinone classes. In addition to its stimulant effects, mephedrone produces side effects , of which bruxism is the most common. The metabolism of mephedrone has been studied in rats and humans and the metabolites can be detected in urine after usage. Mephedrone was first synthesised in , but did not become widely known until it was rediscovered in — at which point it was legal to produce and possess in many countries. By , mephedrone was reported to be available for sale on the internet, by law enforcement agencies had become aware of the compound, and by , it had been reported in most of Europe, becoming particularly prevalent in the United Kingdom. Mephedrone was first made illegal in Israel in , followed by Sweden later that year. In , it was made illegal in many European countries and in December , the EU ruled it illegal. Users have reported that mephedrone causes euphoria , stimulation , an enhanced appreciation for music , an elevated mood , decreased hostility , improved mental function and mild sexual stimulation ; these effects are similar to the effects of cocaine, amphetamines and MDMA, and last different amounts of time depending on the way the drug is taken. Of 70 Dutch users of mephedrone, 58 described it as an overall pleasant experience and 12 described it as an unpleasant experience. The users were also asked to compare the 'risk', and they answered that it was equal. This was contrary to another study in New Zealand, where users of benzylpiperazine thought that because it was legal, it was safe. Mephedrone can come in the form of capsules, tablets or white powder that users may swallow, snort, inject, smoke or use rectally. The effects last for between two and three hours when taken orally or nasally, but only half an hour if taken intravenously. One published study that analysed samples of mephedrone bought using the internet in the UK in found it was racemic a mixture of both stereoisomers and of high purity. The EMCDDA reported mephedrone can cause various unintended side effects including: dilated pupils , \\\\\\\[17\\\\\\\] poor concentration , teeth grinding , problems focusing visually, poor short-term memory , hallucinations , delusions, and erratic behaviour. Other effects users in internet forums have noted include changes in body temperature, increased heart rate , breathing difficulties , loss of appetite, increased sweating , discolouration of extremities, anxiety , paranoia and depression. They reported none of their patients suffered from cold or blue peripheries, contrary to other reports. Nine of the 15 of patients had a Glasgow coma scale GCS of 15, indicating they were in a normal mental state, four had a GCS below 8, but these patients all reported using a central nervous system depressant, most commonly GHB , with mephedrone. The patients also reported polydrug use of a variety of compounds. Neurotoxic effect of mephedrone on serotonin 5-HT and dopamine DA systems remains controversial. Although some studies in animal models reported no damage to DA nerve endings in the striatum and no significant changes in brain monoamine levels, some others suggested a rapid reduction in 5-HT and DA transporter function. Persistent serotonergic deficits were observed after binge like treatment in a warm environment and in both serotonergic and dopaminergic nerve endings at high ambient temperature. Oxidative stress cytotoxicity and an increase in frontal cortex lipid peroxidation were also reported. There have been reports of users craving mephedrone, suggesting it may be addictive. In , one case of sympathomimetic toxicity was reported in the UK after a person took 0. Shortly afterwards, the user 'developed palpitations, blurred tunnel vision, chest pressure and sweating'. The patient was treated with 1 mg of lorazepam and the sympathomimetic features decreased and the user was discharged within six hours of arrival. He was treated with lorazepam and discharged 15 hours after admission. Simon Gibbons and Mire Zloh of the School of Pharmacy, University of London stated, based on the chemical similarities between methcathinone and mephedrone, 'it is highly likely that mephedrone will display neurotoxicity'. They concluded more experimental research is needed to investigate the toxicity of mephedrone. Doctors who treated a year-old female suffering from mephedrone intoxication suggested in The Lancet that, like MDMA, mephedrone may promote serotonin-mediated release of antidiuretic hormone , resulting in hyponatraemia and an altered mental state. The doctors treating the patient stated it was caused by either a direct toxic effect of mephedrone on the heart muscle, or by an immune response. The patient started to recover after arriving at the hospital and it was not necessary to administer any medication. In , an year-old Swedish woman died in Stockholm after taking mephedrone. The newspaper Svenska Dagbladet reported the woman went into convulsions and turned blue in the face. An autopsy showed severe brain swelling. The possession of mephedrone became classified as a criminal offence in Sweden on 15 December In , unconfirmed reports speculated about the role mephedrone has played in the deaths of several young people in the UK. By July , mephedrone had been alleged to be involved in 52 fatalities in the UK, but detected in only 38 of these cases. Of the nine that coroners had finished investigating, two were caused directly by mephedrone. Toxicology reports showed the teenagers had not taken any mephedrone and had died as a result of consuming alcohol and the synthetic opioid agonist methadone. Mephedrone has been implicated in the death of a year-old man, who had also injected black tar heroin. Mephedrone was found in his blood at a concentration of 0. The blood concentration of morphine, a metabolite of heroin, was 0. Mephedrone is a monoamine releasing agent. It is a chiral compound and both of its enantiomers display similar potency as substrates at dopamine transporters. R -Mephedrone is much less potent than S -mephedrone as a substrate at serotonin transporters. The keto oxygen renders mephedrone more hydrophilic than the corresponding amphetamine 4-Methylmethamphetamine , which may account for the higher doses required to achieve a similar effect, because mephedrone is less able to cross the blood—brain barrier. Mephedrone is often consumed with alcohol. A study in mice investigated the interrelation between these two substances, focusing on the psychostimulant and rewarding properties of mephedrone. It found that at low non-stimulant doses alcohol significantly enhanced the psychostimulant effects of mephedrone. This effect was mediated by an increase in synaptic dopamine , as haloperidol , but not ketanserin , was able to block the potentiation by alcohol. Similarly, the rewarding properties of mephedrone were enhanced by a low non-rewarding dose of alcohol. Several articles published near the end of examined the effects of mephedrone, compared to the similar drugs MDMA and amphetamine in the nucleus accumbens of rats, as well as examining the reinforcing potential of mephedrone. Dopamine and serotonin were collected using microdialysis, and increases in dopamine and serotonin were measured using HPLC. Reward and drug seeking are linked to increases in dopamine concentrations in the nucleus accumbens, and drug half-life plays a role in drug seeking, as well. Based on histological examination, most of the author's probes were in the nucleus accumbens shell. They reached their peak concentrations at 40 minutes and 20 minutes, respectively, and returned to baseline by minutes after injection. Analysis of the ratio of the AUC for dopamine DA and serotonin 5-HT indicated mephedrone was preferentially a serotonin releaser, with a ratio of 1. Additionally, half-lives for the decrease in DA and 5-HT were calculated for each drug. Mephedrone had decay rates of MDMA had decay values of Taken together, these findings show mephedrone induces a massive increase in both DA and 5-HT, combined with rapid clearance. The rapid rise and subsequent fall of DA levels could explain some of the addictive properties mephedrone displays in some users. Based on the analysis of rat and human urine by gas chromatography and mass spectrometry , mephedrone is thought to be metabolised by three phase 1 pathways. It can be demethylated to the primary amine producing compounds 2, 3 and 5 , the ketone group can be reduced producing 3 or the tolyl group can be oxidised producing 6. Both 5 and 6 are thought to be further metabolised by conjugation to the glucuronide and sulfate derivatives. Knowledge of the primary routes of metabolism should allow the intake of mephedrone to be confirmed by drug tests , as well as more accurate determination of the causes of side effects and potential for toxicity. Mephedrone may be quantitated in blood, plasma or urine by gas chromatography-mass spectrometry or liquid chromatography-mass spectrometry to confirm a diagnosis of poisoning in hospitalised patients or to provide evidence in a medicolegal death investigation. Mephedrone is a white substance. It is sold most commonly as crystals or a powder, but also in the form of capsules or pills. Mephedrone can be synthesised in several ways. The oil fraction can then be dissolved in dichloromethane CH 2 Cl 2 and drops of the solution added to another solution of CH 2 Cl 2 -containing methylamine hydrochloride and triethylamine. Hydrochloric acid HCl is then added and the aqueous layer is removed and turned alkaline using sodium hydroxide before the amine is extracted using CH 2 Cl 2. The CH 2 Cl 2 is then evaporated using a vacuum, creating an oil which is then dissolved in a nonaqueous ether. Finally, HCl gas is bubbled through the mixture to produce 4-methylmethcathinone hydrochloride. It can also be produced by oxidising the ephedrine analogue 4-methylephedrine using potassium permanganate dissolved in sulfuric acid. Because 4-methylephedrine can be obtained in a specific enantiomeric form, mephedrone consisting of only one enantiomer can be produced. The danger associated with this method is it may cause manganese poisoning if the product is not correctly purified. Mephedrone does not react with most reagent testing kits. The exception is the Liebermann reagent , which gives a bright yellow reaction. Mephedrone is one of hundreds of designer drugs or legal highs that have been reported in recent years, including artificial chemicals such as synthetic cannabis and semisynthetic substances such as methylhexanamine. These drugs are primarily developed to avoid being controlled by laws against illegal drugs, thus giving them the label of designer drugs. A drug similar to mephedrone, containing cathinone , was sold legally in Israel from around , under the name hagigat. When this was made illegal, the cathinone was modified and the new products were sold by the Israeli company, Neorganics. Their research suggested the drug first became available to purchase on the internet in , made available through British contacts, contact unknown, when it was also discussed on internet forums. Europol noted they became aware of it in , after it was found in Denmark, Finland and the UK. Between the summer of and March , the use of mephedrone grew rapidly in the UK, with it becoming readily available at music festivals , head shops and on the internet. Whilst the evidence was anecdotal, researchers, charity workers, teachers and users reported widespread and increasing use of the drug in The drug's rapid growth in popularity was believed to be related to both its availability and legality. Fiona Measham, a criminologist at The University of Lancaster , thought the emergence of mephedrone was also related to the decreasing purity of ecstasy and cocaine on sale in the UK, \\\\\\\[36\\\\\\\] a view reinforced in a report by the National Treatment Agency for Substance Misuse. By December mephedrone was available on at least 31 websites based in the UK and by March there were at least 78 online shops, half of which sold amounts of less than grams and half that also sold bulk quantities. In comparison, over a similar time period, the entries for cocaine and MDMA were accessed approximately times. Media organisations including the BBC and The Guardian incorrectly reported mephedrone was commonly used as a plant fertiliser. In fact sellers of the drug described it as 'plant food' because it was illegal to sell the compound for human consumption. The story was later shown to be an online joke posted on mephedrone. The police report was used as a source for the story in The Sun. On 30 March , Alan Johnson , the then Home Secretary , announced mephedrone would be made illegal 'within weeks' after the ACMD sent him a report on the use of cathinones. He said the decision by the Home Secretary was 'unduly based on media and political pressure' and there was 'little or no discussion about how our recommendation to classify this drug would be likely to impact on young people's behaviour. We need to stop harming people who need help and support'. The parliamentary debate was held on 8 April, one day after the general election had been announced, meaning it was during the so-called ' wash-up period ' when legislation is passed with little scrutiny. Only one hour was spent debating the ban and all three parties agreed, meaning no vote was required. Compared to previous surveys, more users purchased it from dealers, rather than the internet. Of the various drugs used by the survey participants, users were more likely to have concerns about it. Rather than the price rising due to increased scarcity of the drug, it is thought to have risen for two other reasons. Firstly, dealers knew there was still demand for mephedrone, but were aware the supplies may be exhausted in the future. Secondly, the dealers perceived customers were likely to be willing to pay more for an illegal substance. Professor Shiela Bird, a statistician at the Medical Research Council , suggested the ban of mephedrone may lead to more cocaine-related deaths. In the first six months of , the number of cocaine-related deaths fell for the first time in four years, and fewer soldiers tested positive for cocaine in than in She suggested this may have been due to users switching to mephedrone from cocaine, but cautioned that before full figures are available for and , it will be difficult to determine whether mephedrone saved lives, rather than cost them. It was being taken as not only a 'poor man's cocaine' but also amongst users of heroin and crack cocaine. Cases of intravenous use were also reported to be on the increase. When mephedrone was rediscovered in , it was not specifically illegal to possess in any country. As its use has increased, many countries have passed legislation making its possession, sale and manufacture illegal. It was first made illegal in Israel , where it had been found in products such as Neodoves pills, in January In June , it was classified as a narcotic with the possession of 15 grams or more resulting in a minimum of two years in prison—a longer sentence, gram for gram than given for the possession of cocaine or heroin. In , as its use became more prevalent, many countries passed legislation prohibiting mephedrone. On 7 April , the Misuse of Drugs Act Amendment Order was passed by parliament, making mephedrone and other substituted cathinones , Class B drugs from 16 April In some countries, mephedrone is not specifically listed as illegal, but is controlled under legislation that makes compounds illegal if they are analogs of drugs already listed. In Australia during , it was not specifically listed as prohibited, \\\\\\\[49\\\\\\\] but the Australian Federal Police stated it is an analogue to methcathinone and therefore illegal. It is now listed as a Schedule 9 prohibited substance in Australia under the Poisons Standard October In New Zealand , it is not included in the Misuse of Drugs Act , \\\\\\\[\\\\\\\] but is illegal, as it is similar to controlled substances. In Canada , mephedrone is not explicitly listed in any schedule of the Controlled Drugs and Substances Act , but 'amphetamines, their salts, derivatives, isomers and analogues and salts of derivatives, isomers and analogues' are included in Section 19 of Schedule I of the act. Cathinone and methcathinone are listed in separate sections of Schedule III, while diethylpropion and pyrovalerone also cathinones , are listed in separate sections of Schedule IV, each without language to capture analogues, isomers, etc. Mephedrone is also currently scheduled in the United States as of The Drug Enforcement Administration DEA states, as an analogue of methcathinone , possession of mephedrone can be controlled by the Federal Analog Act , but according to the Los Angeles Times , this only applies if it is sold for human consumption. Except as authorised by law, this action made possessing and selling mephedrone or the products that contain it illegal in the US for at least one year while the DEA and the United States Department of Health and Human Services conduct further study. Of those, two-thirds snorted the drug and the average dosage per session was 0. Users who snorted the drug reported using more per session than those who took it orally 0. Professor David Nutt , former chair of the Advisory Council on the Misuse of Drugs ACMD in the UK has said, 'people are better off taking ecstasy or amphetamines than those \\\\\\\[drugs\\\\\\\] we know nothing about' and 'Who knows what's in \\\\\\\[mephedrone\\\\\\\] when you buy it? We don't have a testing system. It could be very dangerous, we just don't know. These chemicals have never been put into animals, let alone humans. He also told the BBC, 'all we can say is \\\\\\\[mephedrone\\\\\\\] is probably as harmful as ecstasy and amphetamines and wait until we have some better scientific evidence to support that. Article Talk. Not to be confused with methedrine , methedrone , mephedrene , methadone , methylone , methcathinone , or ephedrone. IUPAC name. Interactive image. This section needs to be updated. Please help update this article to reflect recent events or newly available information. March Bath salts 4-Methylamphetamine 4-Methylbuphedrone 4-Methylcathinone 4-Methylpentedrone 4-Methylthioamphetamine Methylenedioxyamphetamine Methamphetamine para -Methoxyamphetamine. Annales de Toxicologie Analytique. Retrieved 29 January The Daily Telegraph. Archived from the original on 12 January Retrieved 14 September BBC News. Retrieved 31 March Progress in Neurology and Psychiatry. S2CID April PMID Advisory Council on the Misuse of Drugs. 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