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WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section. It is not a recommendation and should be verified with other sources for accuracy. Mephedrone belongs to a group known as the substituted cathinones , which are derivatives of the active ingredient in the khat plant Catha edulluis. It is thought to produce its effects by promoting the release of the neurotransmitters serotonin , dopamine , and norepinephrine in the brain. Mephedrone was first synthesized in , but did not become widely known until it was rediscovered in In it was reported to be available for sale on the internet, by law enforcement agencies had become aware of the compound, and by it had been reported in most of Europe, becoming particularly prevalent in the United Kingdom. Subjective effects include stimulation , anxiety suppression , disinhibition , enhanced empathy and sociability , relaxation , increased libido , and euphoria. It is reported to produce a mixture of classic stimulant and entactogenic effects reminiscent of cocaine and MDMA. It is also sometimes sold as MDMA 'molly'. Limited data exists about the pharmacological properties, metabolism, and toxicity of mephedrone, and it has little history of human use. Preliminary evidence suggests it may possess neurotoxic and cardiotoxic properties. Mephedrone, or 4-methylmethcathinone, is a synthetic molecule of the cathinone family. Amphetamines and cathinones are alpha-methylated phenethylamines, cathinones contain an additional carbonyl group at R 1. Given its chemical structure, mephedrone is likely to act as a releasing agent and a reuptake inhibitor for monoamine neurotransmitters such as dopamine , serotonin and noradrenaline. Several articles published near the end of examined the effects of mephedrone in the brains of rats, as well as examining the reinforcing potential of mephedrone. Dopamine and serotonin were collected using microdialysis, and increases in dopamine and serotonin were measured. They reached their peak concentrations at 40 minutes and 20 minutes and returned to baseline by minutes after injection. Analysis of the ratio for dopamine and serotonin indicated mephedrone was preferentially a serotonin releaser , with a ratio of 1. Additionally, half-lives for the decrease in dopamine and serotonin were calculated and found to have decay rates of These findings show mephedrone induces a massive increase in both dopamine and serotonin , combined with rapid clearance. This increase in neurotransmitters provides an explanation for the euphoric and stimulating subjective effects induced by this experience. The rapid rise and subsequent fall of dopamine levels could also explain some of the addictive properties of mephedrone display in some users. Disclaimer: The effects listed below cite the Subjective Effect Index SEI , an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism. It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. There are currently no anecdotal reports which describe the effects of this compound within our experience index. Additional experience reports can be found here:. Almost nothing is known about the long-term effects of mephedrone due to its short history of its use. In , unconfirmed reports speculated about the role mephedrone has played in the deaths of several young people in the UK. By July , mephedrone had been alleged to be involved in 52 fatalities in the UK, but detected in only 38 of these cases. Of the nine that coroners had finished investigating, two were caused directly by mephedrone. Despite similarities to known neurotoxins such as methamphetamine and other cathinone derivatives, mephedrone does not appear to produce neurotoxic effects in the dopamine system of mice. It is strongly recommended that one use harm reduction practices when using this drug. As with other stimulants , the chronic use of mephedrone can be considered highly addictive with an extreme potential for abuse and is capable of causing psychological dependence among certain users. When addiction has developed, cravings and withdrawal effects may occur if a person suddenly stops their usage. Tolerance to many of the effects of mephedrone develops with prolonged and repeated use. This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about 3 - 7 days for the tolerance to be reduced to half and 1 - 2 weeks to be back at baseline in the absence of further consumption. Mephedrone presents cross-tolerance with all dopaminergic stimulants , meaning that after the consumption of mephedrone all stimulants will have a reduced effect. Warning: Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions although it is not guaranteed to include all of them. Always conduct independent research e. Google , DuckDuckGo , PubMed to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit. Combinations with the following substances can cause dangerously high serotonin levels. Serotonin syndrome requires immediate medical attention and can be fatal if left untreated. In December , the European Council decided that mephedrone shall be subjected by the Member States to control measures and criminal penalties. From PsychonautWiki. Summary sheet: Mephedrone Mephedrone. Physical effects. Cognitive effects. After effects. ISSN BMJ Clinical research ed. December British Journal of Pharmacology. November The Journal of Pharmacology and Experimental Therapeutics. National Poisons Information Service'. Emergency medicine journal: EMJ. January Addiction Abingdon, England. July Archived from the original PDF on Retrieved Forensic Science International. March Journal of Neurochemistry. Journal of Medical Toxicology. OCLC British Journal of Anaesthesia. PMID Official Journal of the European Union. December 2, L May 26, Die Presse. August 22, Retrieved December 27, State Food and Drug Administration. Archived from the original on 15 August Croatian Ministry of Health and Social Welfare. Estonian Ministry of Social Affairs. Archived from the original on September 21, City Magazine. Retrieved December 10, Bundesanzeiger Verlag. BBC News. April 13, Isle of Man Today. February 25, Archived from the original on February 28, Irish Department of Health and Children. Archived from the original on February 21, Ministero della Salute. BBC Newsbeat. Retrieved December 26, United Nations Office on Drugs and Crime. Archived from the original on February 10, Archived from the original PDF on February 10, Bundeskanzlei \\\\\\\[Federal Chancellery of Switzerland\\\\\\\]. Retrieved January 1, Navigation menu Personal tools Create account Log in. Namespaces Page Discussion. Views Read View source View history. Yolo Donate. Donate Contact us Guidelines Recent changes Open source. Network Good vibes Bad vibes. Summary sheet: Mephedrone.
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