How can I buy cocaine online in Vernier

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How can I buy cocaine online in Vernier

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How can I buy cocaine online in Vernier

Krishna Tulasi Kirla, Ksenia J. Groh, Andrea E. Zebrafish Danio rerio larvae have been suggested as vertebrate model to complement or even replace mammals for rapidly assessing behavioral effects of psychoactive drugs. Yet, divergent responses have been reported in mammals and fish despite the conservation of many drug targets. Cocaine, eg, acts as stimulant in mammals but no such response has been documented for zebrafish larvae. We hypothesized that differences in exposure routes inhalation or injection in mammals vs waterborne in fish may be a reason for differences in behavioral responses. We characterized cocaine toxicokinetics by liquid chromatography-mass spectrometry and found its rapid uptake into larvae. We used Matrix-assisted laser desorption ionization-mass spectrometry imaging for the first time to characterize internal distribution of cocaine in zebrafish larvae. We attribute this to trapping by pigment melanin, a thus far little explored mechanism that may also be relevant for other basic drugs. Cocaine also reached the brain but with levels similar to those in trunk indicating simple passive diffusion as means of distribution which was supported by toxicokinetic models. Although brain levels covered those known to cause hyperactivity in mammals, only hypoactivity decreased locomotion was recorded in zebrafish larvae. Access to content on Oxford Academic is often provided through institutional subscriptions and purchases. If you are a member of an institution with an active account, you may be able to access content in one of the following ways:. Typically, access is provided across an institutional network to a range of IP addresses. This authentication occurs automatically, and it is not possible to sign out of an IP authenticated account. Choose this option to get remote access when outside your institution. 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To purchase short-term access, please sign in to your personal account above. Don't already have a personal account? Oxford University Press is a department of the University of Oxford. It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwide. Sign In or Create an Account. Sign in through your institution. Advanced Search. Search Menu. Article Navigation. Close mobile search navigation Article Navigation. Volume Journal Article. Oxford Academic. Google Scholar. Ksenia J. Andrea E. Michael Poetzsch. Rakesh Kumar Banote. Julita Stadnicka-Michalak. Rik I. Kristin Schirmer 1. E-mail: kristin. Thomas Kraemer. Select Format Select format. Permissions Icon Permissions. Abstract Zebrafish Danio rerio larvae have been suggested as vertebrate model to complement or even replace mammals for rapidly assessing behavioral effects of psychoactive drugs. Issue Section:. You do not currently have access to this article. Download all slides. 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How can I buy cocaine online in Vernier