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Arch Neurosci. In Morocco, cannabis consumption is illegal; however, it is already widely cultivated and consumed in different traditional forms. This drug incorporates cannabis as the principal ingredient, and different substances along with atropine, hallucinogenic plants, poppy seeds, and psychotropic tablets; noticeably, this composition changed into the maximum incriminated substance of drug poisoning instances pronounced of the Poison Control and Pharmacovigilance Centre of Morocco 1. It is a dough crafted from hashish resin and vegetable spices, known for its aphrodisiac effects 1 , 2. This drug, as well as many others, can have negative consequences for drug users, affecting their physical and mental health 3. It can also affect judgment, decrease intellectual functioning, and even lead to memory loss 4. For young populations, specifically adolescents, the risks are high 1. In However, the predominant clinical signs were gastrointestinal for From a psychological and neurological point of view, drug addiction is a direct cause of cognitive disorders. Additionally, the brain regions and processes involved in addiction largely overlap with those involved in critical cognitive functions. These functions include learning, memory, attention, reasoning, and impulse control. These modifications in the brain can lead to neurobehavioral adaptation favoring chronic addiction with difficulty weaning 6. On the other hand, visual attention refers to the cognitive process that mediates the selection of relevant information and the filtering out of data from visual scenes 7. It is a real scourge that is spreading at an alarming rate. At a young age, especially in the school environment, we are witnessing a growing addiction to these substances. The neurological and neurocognitive effects of these drugs have been widely debated. However, Maajoune contains several known highly toxic components, such as cannabis and Papaver somniferum L. The present study aimed to investigate the neurocognitive effects i. It is often eaten with cakes, sweets, dishes, or as an accompaniment to hot drinks. Furthermore, it can be used for addictive purposes given the accessibility of these components, their low cost, and their ease of preparation. The composition of this mixture differs by region; however, Indian hemp is almost constant. The active ingredient is tetrahydrocannabinol THC and its derivatives. Indian hemp is traditional. It is a sedative, narcotic, and antispasmodic, used in three forms: marijuana, hashish, and hashish oil. They can be differentiated according to their THC content and secondly by their method of preparation from female plants. Afterward, consumers add other products whose toxicity varies; there are several varieties depending on the components and the method of preparation. This randomized case-control analytical study was conducted in 3 addiction centers and the Child Protection Center of the central region. Afterward, the control cases were recruited from four schools situated in the same region. Young individuals aged between 10 and 18 years who used Maajoune exclusively were included in the present study. Adolescents who have been diagnosed with neurological diseases causing cognitive disorders e. During the data collection, the privacy and confidentiality of the participants were respected. Therefore, the right to self-determination was also considered. This battery was designed to evaluate areas of cognitive activity suspected of alcohol and other drugs based on research on adults and adolescents 4 , 9 - 11 , identifying six common areas of addiction-related deficits: 1 general intelligence; 2 language; 3 visuospatial; 4 attention; 5 memory; and 6 problem-solving skills. The visual attention function analysis was assessed through the Bells Test, which is both a quantitative and qualitative test for attention deficit neglect. It is widely used for USN diagnosis 12 , 13 ; the patient must cross out bells scattered among several different shapes on a sheet of paper. The test is generally easy to administer and score; it allows quick visualization of the jump locations and the visuospatial model of the scan. Therefore, it provides a sensitive estimate of the USN when the difference is calculated between the number of strikethrough targets on the right side and the number of strikethrough targets on the left side skewness score. This index provides information on the selective omission of target stimuli in the contralesional hemispace, a well-known indication of USN. It was also observed that the omission of target stimuli across the entire sheet and the operating time were effective in assessing attentional processing separately from asymmetric exploration In addition, ignoring target stimuli from the entire sheet and execution time assesses the attentional component independent of asymmetric studies 6 , 7 , 12 , It consists of seven columns, each of which contains a certain number of goals. First, the examined subjects are presented with a sheet of Then, a total of 35 targets bells are distributed equally in seven columns. Out of seven columns, three were on the left side of the page, one was in the middle, and three were on the right side. It can also be suggested as greater neglect of the left side of the space. In this version, a calibration from the primary school levels to the high school levels was added. The statistical analysis was performed using SPSS software version The descriptive analysis consisted of the calculation of absolute and relative frequencies for qualitative variables. Then, positioning and dispersion parameters for quantitative variables were generated using standard statistical parameters i. For this purpose, the current study used a multivariate statistical method, namely correspondence factor analysis CFA and the chi-square test. Their mother is unemployed, and their father is not a drug consumer Figure 4. The mean age of the studied population was 16 years range: 10 - 18 years , with a sex ratio of 0. The mean age of the onset of drug use was 12 years range: 7 - 17 years , the mean duration of use was 3 years range: 1 - 8 years , and the median was 2. The frequency of use was daily in 54 subjects. Attempts to quit were reported by 42 participants, 8 attempts of which were followed by a healthcare professional Table 1. On the other hand, omissions 1 - 4 followed by omissions 0 were related to non-addicts to drugs. The median scores were 26 and Four types of dominant visual neglect were registered Table 2. The average age of the first drug use ranged between 10 and 15 years for 34 adolescents. The neurological effect and induced alteration were not recognized 5 , The duration of drug use was mainly less than 4 years. The Bells Test designed by Gauthier et al. It has been reported that cannabis, ecstasy, amphetamines, and cocaine can impair cognitive functioning. In similar studies, the most common negative effects of illicit drug use were health-related mental disorders, including mood disorders dysphoria , anxiety, panic attacks, sleep disturbances, and memory loss Neglect often occurs after damage to the right hemisphere of the brain caused by a stroke in the middle cerebral artery. Although this abnormality is often associated with parietal lesions, most middle cerebral artery strokes affect multiple regions. Many patients present with various combinations of parietal, temporal, and frontal lesions In addition, neglect might follow a subcortical stroke, although this might be related to hypoperfusion and dysfunction of the upper cortical areas It is believed that these abnormalities are caused by the endogenous cannabinoid system. This regulates a variety of physiological functions via specific cannabinoid receptors CBs expressed in the brain and peripheral tissues. Cannabinoid CB1 receptors mediate various neurological processes; nevertheless, CB2 receptors regulate immune responses and are involved in drug addiction and neuroinflammation Several studies suggest that impairments or abnormalities in different types of tasks are likely localized to some regions. Moreover, neglect results from damage to the neuronal networks of some regions involved in attention Recent studies have shown that it can also result from damage to white matter tracts, particularly the superior longitudinal fasciculus, particularly in the cortical and subcortical regions. Acute intoxication might lead to persistent impairments in emotional and cognitive processing due to irreversible brain damage 13 , The right frontal and parietal regions involved in spatial functions, including attention deployment, are also involved in several non-spatial processes, such as the ability to maintain performance on a task over an extended period of time. The right hemispheric lateralization of these cognitive domains also explains the increased severity of left neglect compared to the right 6 , The present study also diagnosed a right semi-neglect in the group of drug addicts, probably due to a left hemisphere lesion. This syndrome increases the severity of motor and sensory deficits and predicts poor functional prognosis Mild residual impairing effects were also observed in these exact same cognitive domains, suggesting that adverse effects following cannabis intoxication persist for at least days or weeks following cannabis abstinence El Azmy et al. This finding is confirmed by several studies that reported the existence of a link between visual processing and academic success 21 , The drugs consumed by the young participants in the current study will probably affect cognitive functions and engender visual attention deficits, such as visuospatial hemineglect. The results of another study showed that several drugs e. It is possible to think about the need to care for these young individuals with neurocognitive deficits due to this drug addiction. Over the years, a large number of studies and many different techniques have been proposed to treat neglect symptoms. Among these proposed rehabilitation methods are eye-patching, caloric vestibular stimulation, visuomotor imagery, mirror therapy, transcutaneous electrical nerve stimulation TENS , optokinetic stimulation, and constraint-induced movement therapy 1 , The evaluation of the effects of drug addiction, commonly used by young individuals, on cognitive functions indicated a set of cognitive disorders detected in adolescents addicted to different drugs, such as cannabis, synthetic glue, and cocaine. Chronic dependence on these drugs e. It is imperative that drug addiction treatment centers and socio-educational institutions rethink strategies for caring for this population through the development of a more comprehensive care plan for drug addicts based on a holistic and global approach. In addition to assessing physical health, neurocognitive and behavioral disorders associated with drug use also need to be evaluated and corrected. Consequently, it will have a direct impact on their academic progress and future prospects. Madrid, Spain. Clin Toxicol Phila ; Caponi-Tabery GD. Paul Bowles: Romantic Savage. United Nations Office on Drugs and Crime. Scherer KR. Neuroscience findings are consistent with appraisal theories of emotion; but does the brain 'respect' constructionism? Behav Brain Sci. Pharmacological effects of harmine and its derivatives: a review. Arch Pharm Res. Gould TJ. Addiction and cognition. Addict Sci Clin Pract. Visual Attention. Berlin, Heidelberg: Springer; Org Lett. Cognitive loss and recovery in long-term alcohol abusers. Arch Gen Psychiatry. Dhingra VK, Khan S. A sociological study on stigma among TB patients in Delhi. Indian J Tuberc. Front Psychol. J Neurol Neurosci. Ayahuasca and the traveller: A scoping review of risks and possible benefits. Travel Med Infect Dis. Pan Afr Med J. Int J Clin Neuropsychol. Review of the many faces of synthetic cannabinoid toxicities. Ment Health Clin. Neurotoxicity of Exogenous Cannabinoids. In: Kostrzewa RM, editor. Handbook of Neurotoxicity. Cham, Germany: Springer; Ryan C, Butters N. The neuropsychology of alcoholism. The neuropsychology handbook. Bourque J, Potvin S. Front Psychiatry. Cognitive recovery with abstinence and its relationship to family history for alcoholism. J Stud Alcohol. The effects of ecstasy on neurotransmitter systems: a review on the findings of molecular imaging studies. Psychopharmacology Berl. Neuropsychiatr Dis Treat. J Alcoholism Drug Depend. We use cookies to provide you with the best possible experience. They also allow us to analyze user behavior in order to constantly improve the website for you. Navigate to Archives of Neuroscience. Archives of Neuroscience: Vol. Abstract Background: Maajoune is a dough prepared using hemp resin and certain plants known for their aphrodisiac effects. This drug is manufactured in North African countries. The neurocognitive evaluation was performed by the Bells Test visual attention deficits, unilateral spatial neglect, memory, and executive functions. SPSS software version 20 was used to perform statistical analysis consisting of descriptive and qualitative analyses. Results: This study was conducted on participants aged between 10 and 18 years. Conclusions: The study results confirmed that Maajoune consumption significantly affected attention, executive function, and memory in young individuals. These findings highlight the urgent need for research that elucidates the neurobiological changes caused by Maajoune consumption in human health. Background In Morocco, cannabis consumption is illegal; however, it is already widely cultivated and consumed in different traditional forms. Objectives The present study aimed to investigate the neurocognitive effects i. Methods 3. Piece of Maajoune Figure 1. Piece of Maajoune. Figure 2. Bells Test task sheet presented to the subject Gauthier et al. Figure 3. Bells Test scoring sheet used by the examiner Gauthier et al. Figure 4. Epidemiological, social, and environmental characteristics. Table 1. Characteristics of Maajoune Users a. Female; No. Age y Figure 5. Correspondence factor analysis CFA of visual attention test. Table 2. Non-addicts; No. Omissions Figure 6. Sample repartition according to the educational level. Figure 7. Analysis of the effect of Maajoune on attention and working memory. Table 3. Education level 1. References 1. This is an open-access article distributed under the terms of the Creative Commons Attribution 4. Leave a comment here:. Cookie Setting We use cookies to provide you with the best possible experience.

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