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Peganum harmala L. Of these, harmaline, harmine, harmalol and L-peganin vazicin are pharmacologically active. Beta-carboline alkaloids of Peganum harmala L. It was shown that the use of harmine hydrochloride helps to reduce the level of anxiety in animals under conditions of experimental psychoemotional chronic stress with prolonged administration. In the study of acute and chronic toxicity, it was determined that harmine hydrochloride belongs to the category of moderately toxic substances hazard class II. According to the results of molecular docking, the presence of strong bonds in harmine hydrochloride with the serotonin 5-HT 2C receptor, dopamine D 2 receptor, as well as monoamine oxidase A and B was revealed, which indicates the implementation of the mechanism of neurotropic action of harmine hydrochloride at the level of synaptic neurotransmission of monoamines dopamine, serotonin and others. In the course of the study of pharmacokinetics and bioavailability, it was revealed that with the administration of harmine hydrochloride, the quantitative content is quickly achieved and the concentration of the active substance in the blood significantly increases. The relative bioavailability of harmine hydrochloride is A review of ginseng species in different regions as a multipurpose herb in traditional Chinese medicine, modern herbology and pharmacological science. J Med Plants Res. Adaptation of acupuncture and traditional Chinese herbal medicines because of climate change. J Stress Physiol Biochem. The current state of natural thickets of Peganum harmala L. Mashreghi M, Niknia S. The effect of Peganum harmala L. Jundishapur J Microbiol. Spatial pattern analysis of Peganum harmala L. Turk J Bot. Alkaloids from the seeds of Peganum harmala showing antiplasmodial and vasorelaxant activities. J Nat Med. Cytotoxic activity of methanolic extract and two alkaloids extracted from seeds of Peganum harmala L. J Natl Remedies. Efficient in vitro multiplication of Srian Rue Peganum harmala L. Nat Sci. Possible antidiabetic effect Peganum harmala of streptozocine-induced mouse. World Appl Sci J. Antibacterial activity of different parts of Peganum harmala L. Excl J. Antifungal activity of alcoholic extract of Peganum harmala seeds. Toxicity of Peganum harmala: Review and a case report. Iran J Pharmacol Ther. Toxicity of Peganum harmala L. Asgarpanah J, Ramezanloo F. Chemistry, pharmacology and medicinal properties of Peganum harmala L. Afr J Pharm Pharmacol. Asian Pac J Trop Biomed. Medicinal Plants. Moscow: Healing Plants, Higher School; Floral nectar composition of Peganumharmala L. Nat Prod Res. Chemical composition of Peganum harmala L. J Essent Oil Bearing Plants. Phytochemical analysis of selected medicinal plants of Margalla Hills and surroundings. HPLC method for the analysis of harmol, harmalole, harmine and harmaline in the seeds of Peganum harmala L. J Pharm Biomed ; Phytochemical and antimicrobial study of the seeds and leaves of Peganum harmala L. Asian Pac J Trop Dis. Harmine and harmaline. Part IX. Synthesis of harmaline. J Chem Soc. Chemistry, pharmacology, and medical aspects of the plant Peganum harmala L. Pharmaceutical Bulletin. Antitumor and neurotoxic effects of novel harmine derivatives and structure-activity relationship analysis. Int J Cancer. Alkaloids of Peganum harmala L. Georgian Med News. Harmine and imipramine promote antioxidant activities in prefrontal cortex and hippocampus. Oxid Med Cell Longev. Sci Rev Altern Med. Yarnell E, Abascal K. Botanical treatments for depression: Part 2-herbal correctives for systemic imbalances. Altern Complement Ther. Acetylcholinesterase inhibitive activity-guided isolation of two new alkaloids from seeds of Peganum nigellastrum Bunge by an in vitro TLC-bioautographic assay. Arch Pharm Res. Activities of extract and constituents of Banisteriopsis caapi relevant to parkinsonism. Pharmacol Biochem Behav. A dihydro-pyrido-indole potently inhibits HSV-1 infection by interfering the viral immediate early transcriptional events. Antiv Res. Blesa J, Przedborski S. Front Neuroanat. Plant preparations based on indole alkaloids: Biological activity. Biol Med Pharm Chem Issues. Eur J Pharmacol. Effects of harmine on dopamine output and metabolism in rat striatum: Role of monoamine oxidase-a inhibition. Exp Toxicol Pathol. Genotoxic effects of the alkaloids harman and harmine assessed by comet assay and chromosome aberration test in mammalian cells in vitro. Pharmacol Toxicol. Genotoxic and recombinogenic activities of the two beta-carboline alkaloids harman and harmine in Saccharomyces cerevisiae. Mutat Res. Reza VR, Abbas H. Cytotoxicity and antimicrobial activity of harman alkaloids. J Pharmacol Toxicol. Hamsa TP, Kuttan G. Harmine activates intrinsic and extrinsic pathways of apoptosis in B16F melanoma. Chin Med. Ma Y, Wink M. The beta-carboline alkaloid harmine inhibits BCRP and can reverse resistance to the anticancer drugs mitoxantrone and camptothecin in breast cancer cells. Phytother Res. Specific inhibition of cyclin-dependent kinases and cell proliferation by harmine. Biochem Biophys Res Commun. Xanthomicrol is the main cytotoxic component of Dracocephalum kotschyiiand a potential anti-cancer agent. Arch Biochem Biophys. In vivo comparison of harmine efficacy against psychostimulants: Preferential inhibition of the cocaine response through a glutamatergic mechanism. Neurosci Lett. Zhong Z, Tao Y. Treatment with harmine ameliorates functional impairment and neuronal death following traumatic brain injury. Mol Med Rep. Harmine treatment improves short-term memory in older rats: Dissociation of cognition and the ability to meet the procedural requirements of maze testing. Physiol Behav. Becker V, Sipple V. FEBS J. Acute harmine administration induces antidepressive-like effects and increases BDNF levels in the rat hippocampus. Prog Neuropsychopharmacol Biol Psychiatry. Chronic administration of harmine elicits antidepressant-like effects and increases BDNF levels in rat hippocampus. J Neural Transm. In: Khabriev RN, editor. Moscow: Food and Drug Administration; Tutai, Kristina Goldaeva, V. Surov, S. Adekenov Author. Downloads Download data is not yet available. Metrics Metrics Loading Downloads PDF. Published How to Cite 1. Issue Vol. A : A - Basic Sciences. A - Basic Sciences. Maslova, Aidos Doskaliyev, M. Scientific Publications. Make a Submission Make a Submission.