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PPH may cause severe symptoms or be asymptomatic. The treatment of this condition requires dietary changes, but severe cases require drug therapy. The number of therapeutic options is limited and are often associated with adverse side effects. Different classes of drugs have been used and tested, but the resolution of PPH remains a challenge for physicians and patients. In this review, we gathered articles on PPH after BS from PubMed searches to and focused on the main drugs tested for the treatment of this condition, such as acarbose, somatostatin analogues, type 2 sodium-glucose cotransporter inhibitors, calcium channel blockers, and liraglutide. Avexitide and glucagon pump are two new therapeutic options that have been recently tested. Treatment should be individualized and the available therapeutic options may be useful based on the condition's pathophysiology. Open menu Brazil. Archives of Endocrinology and Metabolism. Open menu. Text Texto English. Keywords Postprandial hypoglycemia; gastric bypass; bariatric surgery. Correspondence to: Giovanna B. Disclosure: no potential conflict of interest relevant to this article was reported. Figures 1 Tables 1. Acarbose improves hypoglycaemia following gastric bypass surgery without increasing glucagon-like peptide 1 levels. Obes Surg. Post-prandial hypoglycemia after bariatric surgery: Pharmacological treatment with verapamil and acarbose. Clin Gastroenterol Hepatol. Obes Facts. Safety, efficacy and pharmacokinetics of repeat subcutaneous dosing of avexitide exendin for treatment of post-bariatric hypoglycaemia. Diabetes Obes Metab. Hypoglycemia after gastric bypass successfully treated with calcium channel blockers: Two case reports. J Endocr Soc. Efficacy and safety of diazoxide for treating hyperinsulinemic hypoglycemia: A systematic review and meta-analysis. PLoS One. Use of diazoxide in management of severe postprandial hypoglycemia in patient after Roux-en-Y gastric bypass. Surg Obes Relat Dis. GLP1 analogs as treatment of postprandial hypoglycemia following gastric bypass surgery: A potential new indication? Eur J Endocrinol. A case report: Liraglutide as a novel treatment option in late dumping syndrome. Medicine Baltimore. Stay informed of issues for this journal through your RSS reader. PDF English. Google Google Scholar. Hypoglycemia post bariatric surgery: drugs with different mechanisms of action to treat a unique disorder.