Holed Models

Holed Models

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Выбрать язык русский азербайджанский аймара албанский амхарский арабский армянский ассамский африкаанс бамбара баскский белорусский бенгальский бирманский болгарский боснийский бходжпури валлийский венгерский вьетнамский гавайский галисийский греческий грузинский гуарани гуджарати датский догри зулу иврит игбо идиш илоканский индонезийский ирландский исландский испанский итальянский йоруба казахский каннада каталанский кечуа киргизский китайский (традиционный) китайский (упрощенный) конкани корейский корсиканский коса креольский (гаити) крио курдский (курманджи) курдский (сорани) кхмерский лаосский латинский латышский лингала литовский луганда люксембургский майтхили македонский малагасийский малайский малаялам мальдивский мальтийский маори маратхи мейтейлон (манипури) мизо монгольский немецкий непальский нидерландский норвежский ория оромо панджаби персидский польский португальский пушту руанда румынский самоанский санскрит себуанский сепеди сербский сесото сингальский синдхи словацкий словенский сомалийский суахили сунданский таджикский тайский тамильский татарский телугу тигринья тсонга турецкий туркменский узбекский уйгурский украинский урду филиппинский финский французский фризский хауса хинди хмонг хорватский чви чева чешский шведский шона шотландский (гэльский) эве эсперанто эстонский яванский японский

A model of semiconductor behaviour in which
donors contribute a positive charge equal in magnitude to the
charge of an electron , and acceptors contribute space for such
a charge within the crystal lattice.

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Affiliations

1 School of Medicine, Stanford University, Palo Alto, CA, USA.

2 School of Medicine, Stanford University, Palo Alto, CA, USA. jhelms@stanford.edu.

Zhijun Li et al.

Methods Mol Biol .

2021 .

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1 School of Medicine, Stanford University, Palo Alto, CA, USA.

2 School of Medicine, Stanford University, Palo Alto, CA, USA. jhelms@stanford.edu.

Hu K, Besschetnova TY, Olsen BR.
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PMID: 27658810

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Biochem Biophys Res Commun. 2006 Nov 24;350(3):557-61. doi: 10.1016/j.bbrc.2006.09.079. Epub 2006 Sep 25.
Biochem Biophys Res Commun. 2006.

PMID: 17022937

Einhorn TA.
Einhorn TA.
Clin Orthop Relat Res. 1998 Oct;(355 Suppl):S7-21. doi: 10.1097/00003086-199810001-00003.
Clin Orthop Relat Res. 1998.

PMID: 9917622

Dennis SC, Berkland CJ, Bonewald LF, Detamore MS.
Dennis SC, et al.
Tissue Eng Part B Rev. 2015 Jun;21(3):247-66. doi: 10.1089/ten.TEB.2014.0419. Epub 2014 Dec 4.
Tissue Eng Part B Rev. 2015.

PMID: 25336144
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Borrelli J Jr, Pape C, Hak D, Hsu J, Lin S, Giannoudis P, Lane J.
Borrelli J Jr, et al.
J Orthop Trauma. 2012 Dec;26(12):708-11. doi: 10.1097/BOT.0b013e318274da8b.
J Orthop Trauma. 2012.

PMID: 23047710

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Wang J, Yang C, Kong F, Zhang Z, Ji S, Sun G.
Wang J, et al.
Stem Cells Int. 2022 Jul 18;2022:2091615. doi: 10.1155/2022/2091615. eCollection 2022.
Stem Cells Int. 2022.

PMID: 35898655
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Yan CP, Wang XK, Jiang K, Yin C, Xiang C, Wang Y, Pu C, Chen L, Li YL.
Yan CP, et al.
Front Cell Dev Biol. 2022 May 20;10:883228. doi: 10.3389/fcell.2022.883228. eCollection 2022.
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PMID: 35669516
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Zhang C, Wu S, Chen E, Yu L, Wang J, Wu M.
Zhang C, et al.
Cell Mol Life Sci. 2022 May 31;79(6):328. doi: 10.1007/s00018-022-04338-7.
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Shen H, Gardner AM, Vyas J, Ishida R, Tawfik VL.
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Front Pharmacol. 2021.

PMID: 33597884
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Our understanding of the mechanisms underlying fracture healing is rapidly developing and is contributing to new therapeutic strategies to enhance repair. To gain new insights, animal models must also evolve. From initially imprecise, uncontrolled bone defects we now have precise injury models that still capture all of the stages and phases of bone repair yet do so in a highly reproducible manner. The simple mono-cortical defect model allows assessment of bone repair through a cartilage intermediate, e.g., endochondral ossification, as well as direct bone repair, e.g., intramembranous healing. Cellular contributions of the periosteum can be distinguished from contributions originating in the bone marrow. In this chapter, we focus on the advantages of this bone repair model, as well as its limitations.

Keywords:

Animal model; Bone regeneration; Fracture healing; Orthopedics.

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