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Active Brazilian crack cocaine users: nutritional, anthropometric, and drug use profiles

Guimaraes where can I buy cocaine

The sensitivity to noradrenaline and the termination of its action in the isolated venous tissue of the dog as well as the capacity of the tissue to remove noradrenaline from the incubation medium were studied either in normal, surgically denervated or cocaine-treated strips. Cocaine or denervation had strikingly similar effects on the parameters under study, causing supersensitivity and inhibition of noradrenaline inactivation and uptake mechanisms; in no instance did cocaine differ significantly from denervation. However, both cocaine and denervation exerted a more marked influence on sensitivity to than on inactivation of noradrenaline. These results suggest that neuronal uptake plays roles of different importance in regulating the initial concentration of noradrenaline at the receptor level and in terminating the action of noradrenaline, probably because it is the first mechanism to operate when the strip is exposed to noradrenaline but has a relatively low capacity. Venous strips had a considerable capacity for removing noradrenaline from the incubation medium. More than half the removed noradrenaline was accumulated in neuronal structures; the rest seems to have been extraneuronally metabolized. Excellent correlations between noradrenaline content and removal capacity, sensitivity to noradrenaline, inactivation capacity and potentiation by cocaine were found. On the whole the results give evidence for a prejunctional site of action of cocaine. This is a preview of subscription content, log in via an institution to check access. Rent this article via DeepDyve. Institutional subscriptions. Bevan, J. Google Scholar. Davidson, W. Euler, U. Acta physiol. Furchgott, R. Graefe, K. Naunyn-Schmiedebergs Arch. Pharmacol in press. Haefely, W. Haeusler, G. Kalsner, S. Kasuya, Y. Kopin, I. Lindmar, R. McMillan, W. Maxwell, R. Muscholl, E. Osswald, W. Palmer, J. Indian med. Smith, C. Trendelenburg, U. Varma, D. Download references. Guimaraes, W. You can also search for this author in PubMed Google Scholar. Reprints and permissions. Guimaraes, S. The effects of cocaine and denervation on the sensitivity to noradrenaline, its uptake and the termination of its action in isolated venous tissue. Download citation. Received : 02 June Issue Date : September Anyone you share the following link with will be able to read this content:. Sorry, a shareable link is not currently available for this article. Provided by the Springer Nature SharedIt content-sharing initiative. Summary The sensitivity to noradrenaline and the termination of its action in the isolated venous tissue of the dog as well as the capacity of the tissue to remove noradrenaline from the incubation medium were studied either in normal, surgically denervated or cocaine-treated strips. Access this article Log in via an institution. Brain mapping: topography of neurons and their transmitters involved in various brain functions Article 15 May References Bevan, J. Google Scholar Davidson, W. Google Scholar Euler, U. Google Scholar Furchgott, R. Google Scholar Graefe, K. Google Scholar Haefely, W. Google Scholar Haeusler, G. Google Scholar Kalsner, S. Google Scholar — —: Mechanism of cocaine potentiation of responses to amines. Google Scholar Kasuya, Y. Google Scholar Kopin, I. Google Scholar Lindmar, R. Google Scholar McMillan, W. Google Scholar Maxwell, R. Google Scholar Muscholl, E. Google Scholar Osswald, W. Google Scholar Palmer, J. Google Scholar Smith, C. Google Scholar Trendelenburg, U. Google Scholar —: Mechanisms of supersensitivity to sympathomimetic amines. Google Scholar —, Muskus, A. Google Scholar Varma, D. Google Scholar Download references. Branco Authors S. Guimaraes View author publications. View author publications. Additional information The authors are indebted to Prof. Maia for valuable statistical advice. Rights and permissions Reprints and permissions. About this article Cite this article Guimaraes, S. Copy to clipboard. Search Search by keyword or author Search. Navigation Find a journal Publish with us Track your research.

Guimaraes where can I buy cocaine