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Methadone is also known as: Medically reviewed on Oct 12, This drug should be used during pregnancy only if the benefit clearly outweighs the risk to the fetus. AU TGA pregnancy category: Studies have shown the benefits of pharmacotherapy for opioid use disorder OUD during pregnancy outweigh the risks of untreated OUD. Treatment of OUD helps to block the cyclic withdrawal symptoms associated with misuse of opioids and provide a more stabilized intrauterine environment. Untreated opioid addiction is associated with adverse obstetrical outcomes such as low birth weight, preterm birth, and fetal death; untreated opioid addiction often results in continued or relapsing illicit opioid use. An expert review of published data by TERIS Teratogen Information System concludes that maternal use during pregnancy as part of a supervised, therapeutic regimen is unlikely to pose a substantial teratogenic risk. The relevance of these findings to the use of this drug in chronic pain patients is unclear. Neonatal opioid withdrawal syndrome is an expected and treatable outcome of prolonged use during pregnancy. Several studies have reported decreased fetal growth in infants born to narcotic-addicted women treated with methadone during all or part of their pregnancy; however, this growth deficit does not appear to persist into later childhood. Mild but persistent deficits in performance on psychometric and behavioral tests have been demonstrated. There is conflicting data on whether the risk of sudden infant death syndrome is increased. There are no controlled studies of methadone use in pregnant women. Chronic use of opioids may cause reduced fertility in females and males of reproductive potential; it is not known whether these effects on fertility are reversible. Reproductive function in human males may be decreased; reduced ejaculate volume, seminal vesicle and prostate secretions have been reported as well as reductions in serum testosterone levels, sperm motility, and abnormalities in sperm morphology. Drugs which, owing to their pharmacological effects, have caused or may be suspected of causing, harmful effects on the human fetus or neonate without causing malformations. These effects may be reversible. Accompanying texts should be consulted for further details. Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks. Peak methadone levels occur about 4 to 5 hours after an oral dose. A breastfed infant would receive approximately Cases of sedation and respiratory depression in breastfed infants exposed to methadone have been received. There is no information on use of parenteral methadone in breastfeeding, or the safety of high dose methadone typically used for chronic pain management. Pregnant mothers need to know when they should or should not breastfeed; a stable mother being treated for opioid use disorder is encouraged to breastfeed, although there are situations where breastfeeding is not recommended e. If breastfeeding is being considered, counseling should include: Use is considered acceptable; caution is recommended Excreted into human milk: Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. By clicking Subscribe, I agree to the Drugs. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Available for Android and iOS devices. Subscribe to receive email notifications whenever new articles are published. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. To view content sources and attributions, please refer to our editorial policy. We comply with the HONcode standard for trustworthy health information - verify here. Methadone Pregnancy and Breastfeeding Warnings Methadone is also known as: References for pregnancy information Cerner Multum, Inc. Methadone Rating User Reviews 8. Subscribe to free Drugs. FDA alerts for all medications.

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