Галерея 3457758

Галерея 3457758

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Biochemistry. 2012 Sep 25; 51(38): 7456–7464.
Published online 2012 Sep 4. doi: 10.1021/bi300871k
† Department of Anatomy and Neurobiology,
School of Medicine, University of Maryland−Baltimore, Baltimore, Maryland 21201, United States
‡ Department of Molecular Biology
and Genetics, Science Park, Aarhus University, 8000 Aarhus C, Denmark
* Department
of Anatomy and Neurobiology,
University of Maryland, School of Medicine, HSF II, Room S251, 20
Penn St., Baltimore, MD 21201. Phone: (410) 706-4778. Fax: (410) 706-2512. E-mail: ude.dnalyramu@100dnili .
Received 2012 Jun 28; Revised 2012 Aug 31
Copyright © 2012 American
Chemical Society
This is an open-access article distributed under the ACS AuthorChoice Terms & Conditions. Any use of this article, must conform to the terms of that license which are available at http://pubs.acs.org .
Secondary Structure Analysis of 7B2
Forms
Hsi K. L.; Seidah N. G.; De Serres G.; Chretien M. (1982) Isolation and NH2-terminal
sequence of a novel porcine anterior pituitary polypeptide. Homology
to proinsulin, secretin and Rous sarcoma virus transforming protein
TVFV60 . FEBS Lett.
147 , 261–266. [ PubMed ] [ Google Scholar ] Braks J. A. M.; Martens G. J. M. (1994) 7B2 is a neuroendocrine chaperone
that transiently interacts with prohormone convertase PC2 in the secretory
pathway . Cell
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cells and is required for the expression of enzymatic activity . J. Cell Biol.
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intracellular binding protein of the prohormone convertase PC2 . J. Neurochem.
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structure in the interaction of 7B2 with prohormone convertase 2 . J. Biol. Chem.
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contains all of the information required for 7B2-mediated activation
of prohormone convertase 2 . J. Biol. Chem.
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polypeptide 7B2 is a precursor protein . J. Biol.
Chem.
265 , 15644–15647. [ PubMed ] [ Google Scholar ] Paquet L.; Bergeron F.; Boudreault A.; Seidah N. G.; Chretien M.; Mbikay M.; Lazure C. (1994) The neuroendocrine
precursor 7B2
is a sulfated protein proteolytically processed by a ubiquitous furin-like
convertase . J. Biol. Chem.
269 , 19279–19285. [ PubMed ] [ Google Scholar ] Fortenberry Y.; Liu J.; Lindberg I. (1999) The role of
the 7B2 CT peptide in the inhibition of
prohormone convertase 2 in endocrine cell lines . J. Neurochem.
73 , 994–1003. [ PubMed ] [ Google Scholar ] Mbikay M.; Seidah N. G.; Chretien M. (2001) Neuroendocrine secretory protein
7B2: Structure, expression and functions . Biochem.
J.
357 , 329–342. [ PMC free article ] [ PubMed ] [ Google Scholar ] Chaudhuri B.; Stephan C.; Huijbregts R. P.; Martens G. J. (1995) The neuroendocrine
protein 7B2 acts as a molecular chaperone in the in vitro folding
of human insulin-like growth factor-1 secreted from yeast . Biochem. Biophys. Res. Commun.
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convertase 2 . Endocrinology
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synaptic vesicles . Brain Res.
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to proinsulin, secretin and Rous sarcoma virus transforming protein
TVFV60 . FEBS Lett.
147 , 261–266. [ PubMed ] [ Google Scholar ] [ Ref list ]
Zhu X.; Lindberg I. (1995) 7B2 facilitates the maturation of proPC2 in neuroendocrine
cells and is required for the expression of enzymatic activity . J. Cell Biol.
129 , 1641–1650. [ PMC free article ] [ PubMed ] [ Google Scholar ] [ Ref list ]
Benjannet S.; Savaria D.; Chretien M.; Seidah N. G. (1995) 7B2 is a specific
intracellular binding protein of the prohormone convertase PC2 . J. Neurochem.
64 , 2303–2311. [ PubMed ] [ Google Scholar ] [ Ref list ]
Muller L.; Zhu P.; Juliano M. A.; Juliano L.; Lindberg I. (1999) A 36-residue peptide
contains all of the information required for 7B2-mediated activation
of prohormone convertase 2 . J. Biol. Chem.
274 , 21471–21477. [ PubMed ] [ Google Scholar ] [ Ref list ]
Ayoubi T. A.; van Duijnhoven H. L.; van de Ven W. J.; Jenks B. G.; Roubos E. W.; Martens G. J. (1990) The neuroendocrine
polypeptide 7B2 is a precursor protein . J. Biol.
Chem.
265 , 15644–15647. [ PubMed ] [ Google Scholar ] [ Ref list ]
Paquet L.; Bergeron F.; Boudreault A.; Seidah N. G.; Chretien M.; Mbikay M.; Lazure C. (1994) The neuroendocrine
precursor 7B2
is a sulfated protein proteolytically processed by a ubiquitous furin-like
convertase . J. Biol. Chem.
269 , 19279–19285. [ PubMed ] [ Google Scholar ] [ Ref list ]
Fortenberry Y.; Liu J.; Lindberg I. (1999) The role of
the 7B2 CT peptide in the inhibition of
prohormone convertase 2 in endocrine cell lines . J. Neurochem.
73 , 994–1003. [ PubMed ] [ Google Scholar ] [ Ref list ]
Mbikay M.; Seidah N. G.; Chretien M. (2001) Neuroendocrine secretory protein
7B2: Structure, expression and functions . Biochem.
J.
357 , 329–342. [ PMC free article ] [ PubMed ] [ Google Scholar ] [ Ref list ]
Chaudhuri B.; Stephan C.; Huijbregts R. P.; Martens G. J. (1995) The neuroendocrine
protein 7B2 acts as a molecular chaperone in the in vitro folding
of human insulin-like growth factor-1 secreted from yeast . Biochem. Biophys. Res. Commun.
211 , 417–425. [ PubMed ] [ Google Scholar ] [ Ref list ]
Lee S. N.; Lindberg I. (2008) 7B2 prevents unfolding and aggregation of prohormone
convertase 2 . Endocrinology
149 , 4116–4127. [ PMC free article ] [ PubMed ] [ Google Scholar ] [ Ref list ]
Pasinetti G. M.; Ungar L. H.; Lange D. J.; Yemul S.; Deng H.; Yuan X.; Brown R. H.; Cudkowicz M. E.; Newhall K.; Peskind E.; Marcus S.; Ho L. (2006) Identification
of potential CSF biomarkers in ALS . Neurology
66 , 1218–1222. [ PubMed ] [ Google Scholar ] [ Ref list ]
Jahn H.; Wittke S.; Zurbig P.; Raedler T. J.; Arlt S.; Kellmann M.; Mullen W.; Eichenlaub M.; Mischak H.; Wiedemann K. (2011) Peptide fingerprinting
of Alzheimer’s
disease in cerebrospinal fluid: Identification and prospective evaluation
of new synaptic biomarkers . PLoS One
6 , e26540. [ PMC free article ] [ PubMed ] [ Google Scholar ] [ Ref list ]
Marcinkiewicz M.; Benjannet S.; Cantin M.; Seidah N. G.; Chretien M. (1986) CNS distribution
of a novel pituitary protein '7B2': Localization in secretory and
synaptic vesicles . Brain Res.
380 , 349–356. [ PubMed ] [ Google Scholar ] [ Ref list ]
Zhu X.; Lamango N. S.; Lindberg I. (1996) Involvement
of a polyproline helix-like
structure in the interaction of 7B2 with prohormone convertase 2 . J. Biol. Chem.
271 , 23582–23587. [ PubMed ] [ Google Scholar ] [ Ref list ]
Lindberg I.; Tu B.; Muller L.; Dickerson I. M. (1998) Cloning and functional analysis of C. elegans 7B2 . DNA Cell Biol.
17 , 727–734. [ PubMed ] [ Google Scholar ] [ Ref list ]
Romero P.; Obradovic Z.; Li X.; Garner E. C.; Brown C. J.; Dunker A. K. (2001) Sequence complexity of disordered
protein . Proteins
42 , 38–48. [ PubMed ] [ Google Scholar ] [ Ref list ]
Hwang J. R.; Lindberg I. (2001) Inactivation of the 7B2 inhibitory CT peptide depends
on a functional furin cleavage site . J. Neurochem.
79 , 437–444. [ PubMed ] [ Google Scholar ] [ Ref list ]
Morrisett J. D.; David J. S.; Pownall H. J.; Gotto A. M. Jr. (1973) Interaction of an apolipoprotein
(apoLP-alanine) with phosphatidylcholine . Biochemistry
12 , 1290–1299. [ PubMed ] [ Google Scholar ] [ Ref list ]
Chen Y. H.; Yang J. T.; Chau K.
Изголодавшаяся по хую девушка ебет себя сладкой конфеткой
Недостриптиз молодой
Девка с обворожительной фигурой в купальнике в дырочку лежит на песке

Галерея 3457758

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