Галерея 3412151

Галерея 3412151
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Immunity. Author manuscript; available in PMC 2013 Jun 29.
Find articles by Giorgio Trinchieri
1 Laboratory of Experimental Immunology, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702
2 Immunobiology Section, Laboratory of Parasitic Diseases, National Institutes of Health, Bethesda, MD 20892
3 Mucosal Immunobiology Section, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892
* Correspondence to: Romina S. Goldszmid; vog.hin.liam@dimzsdlogr Tel: (301) 846-7057, Fax: (301) 846-6449; Giorgio Trinchieri; vog.hin.liam@gihcnirt Tel: (301) 846-1323, Fax: (301) 846-1673 or Alan Sher; vog.hin.diain@rehsa Tel: (301) 496-3535, Fax: (301) 402-0890
¶ These authors have equally contributed to this work.
The publisher's final edited version of this article is available at Immunity
GUID: BBA817A9-E41D-4226-B474-10A4C9C69F21
Recruited monocytes replace macrophages and DCs at the infection site
NK cell-derived IFN-γ drives the loss of tissue resident mononuclear phagocytes
NK cell-derived IFN-γ drives the local differentiation of monocytes into macrophages and DCs
Monocyte-derived DCs are the major source of IL-12 at the site of infection
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Heath WR, Carbone FR. Dendritic cell subsets in primary and secondary T cell responses at body surfaces. Nat Immunol. 2009; 10 :1237–1244. [ PubMed ] [ Google Scholar ] [ Ref list ]
Bogunovic M, Ginhoux F, Helft J, Shang L, Hashimoto D, Greter M, Liu K, Jakubzick C, Ingersoll MA, Leboeuf M, et al. Origin of the lamina propria dendritic cell network. Immunity. 2009; 31 :513–525. [ PMC free article ] [ PubMed ] [ Google Scholar ] [ Ref list ]
del Hoyo GM, Martin P, Vargas HH, Ruiz S, Arias CF, Ardavin C. Characterization of a common precursor population for dendritic cells. Nature. 2002; 415 :1043–1047. [ PubMed ] [ Google Scholar ] [ Ref list ]
Liu K, Victora GD, Schwickert TA, Guermonprez P, Meredith MM, Yao K, Chu FF, Randolph GJ, Rudensky AY, Nussenzweig M. In vivo analysis of dendritic cell development and homeostasis. Science. 2009; 324 :392–397. [ PMC free article ] [ PubMed ] [ Google Scholar ] [ Ref list ]
Naik SH, Sathe P, Park HY, Metcalf D, Proietto AI, Dakic A, Carotta S, O’Keeffe M, Bahlo M, Papenfuss A, et al. Development of plasmacytoid and conventional dendritic cell subtypes from single precursor cells derived in vitro and in vivo. Nat Immunol. 2007; 8 :1217–1226. [ PubMed ] [ Google Scholar ] [ Ref list ]
Varol C, Vallon-Eberhard A, Elinav E, Aychek T, Shapira Y, Luche H, Fehling HJ, Hardt WD, Shakhar G, Jung S. Intestinal lamina propria dendritic cell subsets have different origin and functions. Immunity. 2009; 31 :502–512. [ PubMed ] [ Google Scholar ] [ Ref list ]
Cheong C, Matos I, Choi JH, Dandamudi DB, Shrestha E, Longhi MP, Jeffrey KL, Anthony RM, Kluger C, Nchinda G, et al. Microbial stimulation fully differentiates monocytes to DC-SIGN/CD209(+) dendritic cells for immune T cell areas. Cell. 2010; 143 :416–429. [ PMC free article ] [ PubMed ] [ Google Scholar ] [ Ref list ]
Jakubzick C, Tacke F, Ginhoux F, Wagers AJ, van Rooijen N, Mack M, Merad M, Randolph GJ. Blood monocyte subsets differentially give rise to CD103+ and CD103− pulmonary dendritic cell populations. J Immunol. 2008; 180 :3019–3027. [ PubMed ] [ Google Scholar ] [ Ref list ]
Randolph GJ, Inaba K, Robbiani DF, Steinman RM, Muller WA. Differentiation of phagocytic monocytes into lymph node dendritic cells in vivo. Immunity. 1999; 11 :753–761. [ PubMed ] [ Google Scholar ] [ Ref list ]
Sallusto F, Lanzavecchia A. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. J Exp Med. 1994; 179 :1109–1118. [ PMC free article ] [ PubMed ] [ Google Scholar ] [ Ref list ]
Geissmann F, Jung S, Littman DR. Blood monocytes consist of two principal subsets with distinct migratory properties. Immunity. 2003; 19 :71–82. [ PubMed ] [ Google Scholar ] [ Ref list ]
Gordon S, Taylor PR. Monocyte and macrophage heterogeneity. Nat Rev Immunol. 2005; 5 :953–964. [ PubMed ] [ Google Scholar ] [ Ref list ]
Nakano H, Lin KL, Yanagita M, Charbonneau C, Cook DN, Kakiuchi T, Gunn MD. Blood-derived inflammatory dendritic cells in lymph nodes stimulate acute T helper type 1 immune responses. Nat Immunol. 2009; 10 :394–402. [ PMC free article ] [ PubMed ] [ Google Scholar ] [ Ref list ]
Serbina NV, Salazar-Mather TP, Biron CA, Kuziel WA, Pamer EG. TNF/iNOS-producing dendritic cells mediate innate immune defense against bacterial infection. Immunity. 2003; 19 :59–70. [ PubMed ] [ Google Scholar ] [ Ref list ]
Trinchieri G. Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat Rev Immunol. 2003; 3 :133–146. [ PubMed ] [ Google Scholar ] [ Ref list ]
Ma X, Chow JM, Gri G, Carra G, Gerosa F, Wolf SF, Dzialo R, Trinchieri G. The interleukin 12 p40 gene promoter is primed by interferon gamma in monocytic cells. J Exp Med. 1996; 183 :147–157. [ PMC free article ] [ PubMed ] [ Google Scholar ] [ Ref list ]
Abdi K, Singh N, Matzinger P. T-cell control of IL-12p75 production. Scand J Immunol. 2006; 64 :83–92. [ PubMed ] [ Google Scholar ] [ Ref list ]
Bliss SK, Zhang Y, Denkers EY. Murine neut
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Галерея 3412151

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