Галерея 3301901

Галерея 3301901

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Effect of Adaptive Changes of Lysophosphatidylethanolamine Content on Ampicillin Resistance of Yersinia Pseudotuberculosis
Published: 12 November 2018 Publication History
ICBBE '18: Proceedings of the 2018 5th International Conference on Biomedical and Bioinformatics Engineering
Qualifiers research-article Research Refereed limited
Funding Sources Russian Science Foundation
Bakholdina, S.I., Sanina, N.M., Krasikova, I.N., Popova, O.B., and Solov'eva, T.F. 2004. The impact of abiotic factors (temperature and glucose) on physicochemical properties of lipids from Yersinia pseudotuberculosis. Biochimie. 86, 875--881. Google Scholar Cross Ref Bonke, R., Wacheck, S., Stüber, E., Meyer, C., Märtlbauer, E., and Fredriksson-Ahomaa, M. 2011. Antimicrobial susceptibility and distribution of β-lactamase A (blaA) and β-lactamase B (blaB) genes in enteropathogenic Yersinia species. Microb. Drug. Resist. 17, 575--581. Google Scholar Cross Ref Bystritskaya, E.P., Stenkova, A.M., Portnyagina, O.Y., Rakin, A.V., Rasskazov, V.A., and Isaeva, M.P. 2014. Regulation of Yersinia pseudotuberculosis major porin expression in response to antibiotic stress. Mol. Gen. Mikrobiol. Virusol. 2, 63--68. Google Scholar Cabanel, N., Galimand, M., Bouchier, C., Chesnokova, M., Klimov, V., and Carniel, E. 2017. Molecular bases for multidrug resistance in Yersinia pseudotuberculosis. Int. J. Med. Microbiol. 307, 371--381. Google Scholar Cross Ref Daglia, M. 2012. Polyphenols as antimicrobial agents. Curr. Opin. Biotechnol. 23, 174--181. Google Scholar Cross Ref Davydova, L.A., Bakholdina, S.I., Barkina, M.Yu., Velansky, P.V., Bogdanov, M.V., and Sanina N.M. 2016. Effect of elevated growth temperature and heat shock on lipid composition of inner and outer membranes of Yersinia pseudotuberculosis. Biochimie. 123, 103--109. Google Scholar Cross Ref Davydova, L.A., Sanina, N.M., Novikova, O.D., Portnyagina, O.Y., Bakholdina, S.I., Velansky, P.V., et al. 2015. Opposite effects of lysophosphatidylethanolamines on conformation of OmpF-like porin from Yersinia pseudotuberculosis. Protein. Pept. Lett. 22, 1060--1065. Google Scholar Cross Ref Delcour, A.H. 2009. Outer membrane permeability and antibiotic resistance. Biochim. Biophys. Acta. 1794, 808--816. Google Scholar Cross Ref Ekambaram, S.P., Perumal, S.S., Balakrishnan, A., Marappan, N., Gajendran, S.S., and Viswanathan V. 2016. Antibacterial synergy between rosmarinic acid and antibiotics against methicillin-resistant Staphylococcus aureus. J. Intercult. Ethnopharmacol. 5, 358--363. Google Scholar Cross Ref El-Halfawy, O.M., and Valvano, M.A. 2012. Non-genetic mechanisms communicating antibiotic resistance: rethinking strategies for antimicrobial drug design. Expert. Opin. Drug. Discov. 7, 923--933. Google Scholar Cross Ref Fei, Q., Kent, D., Botello-Smith, W.M., Nur, F., Nur, S., Alsamarah, A., et al. 2018. Molecular mechanism of resveratrol's lipid membrane protection. Sci. Rep. 8:1587. Google Scholar Folch, J., Lees, M., and Sloane-Stanley, G.H. 1957. A simple method for the isolation and purification of total lipids from animal tissues. J. Biol. Chem. 14, 497--509. Google Scholar Ghai, I., and Ghai, S. 2017. Exploring bacterial outer membrane barrier to combat bad bugs. Infect. Drug. Resist. 30, 261--273. Google Scholar Cross Ref Grumezescu, V., Holban, A.M., Barbu, I., Popescu, R.C., Oprea, A.E., Lazar, V., et al. 2016. «Nanoarchitectonics used in antiinfective therapy» in Antibiotic resistance: mechanisms and new antimicrobial approaches, ed K. Kon, Google Scholar Kloster, M.B. 1974. Determination of tannin and lignin. J. Amer. Water. Works. Assoc. 66:44. Google Scholar Cross Ref Laxminarayan, R., Duse, A., Wattal, C., Zaidi, A.K., Wertheim, H.F., Sumpradit, N., et al. 2013. Antibiotic resistance - the need for global solutions. Lancet. Infect. Dis. 13, 1057--1098. Google Scholar Cross Ref Livak, K.J., and Schmittgen T.D. 2001. Analysis of relative gene expression data using real-time quantitative PCR and the 2-ΔΔCT Method. Methods. 25, 402--408. Google Scholar Cross Ref Martínez-Martínez, L., Conejo, M.C., Pascual, A., Hernández-Allés, S., Ballesta, S., Ramírez De Arellano-Ramos, E., et al. 2000. Activities of imipenem and cehalosporins against clonally related strains of Escherichia coli hyperproducing chromosomal beta-lactamase and showing altered porin profiles. Antimicrob. Agents. Chemother. 44, 2534--2536. Google Scholar Cross Ref Masi, M. Réfregiers, K.M. Pos, J.M. Pagès. 2017. Mechanisms of envelope permeability and antibiotic influx and efflux in Gram-negative bacteria. Nat. Microbiol. 2, 1700. Google Scholar Cross Ref Moya-Torres, A., Mulvey, M.R., Kumar, A., Oresnik, I.J., and Brassinga, A.K. 2014. The lack of OmpF, but not OmpC, contributes to increased antibiotic resistance in Serratia marcescens. Microbiology. 160:1882--1892. Google Scholar Cross Ref Pagès, J.M., James, C.E., and Winterhalter M. 2008. The porin and the permeating antibiotic: a selective diffusion barrier in Gram-negative bacteria. Nat. Rev. Microbiol. 6, 893--903. Google Scholar Cross Ref Reutov, V.A., Zabolotnaya, A.M., Anufriev, A.V., and Lim, L.A. 2018. Method for obtaining dye from buckwheat husks. Patent of Russian Federation RU2653025. Priority - May 04 Google Scholar Rogers, G.B., Carroll, M.P., and Bruce, K.D. 2012. Enhancing the utility of existing antibiotics by targeting bacterial behaviour? Br. J. Pharmacol. 165:845--857. Google Scholar Cross Ref Sanina, N., Davydova, L., Bakholdina, S., Novikova, O., Pornyagina, O., Solov'eva, T., et al. 2013. Effect of phenol-induced changes in lipid composition on conformation of OmpF-like porin of Yersinia pseudotuberculosis. FEBS Lett. 587, 2260--2265. Google Scholar Cross Ref Scorciapino, M.A., Acosta-Gutierrez, S., Benkerrou, D., D'Agostino, T., Malloci, G., Samanta, S., et al. 2017. Rationalizing the permeation of polar antibiotics intoGram-negative bacteria. J. Phys. Condens. Matter. 29:113001. Google Scholar Cross Ref Thomas, A.D., and Booth, I.R. 1992. The regulation of expression of the porin gene ompC by acid pH. J. Gen. Microbiol. 138, 1829--1835. Google Scholar Cross Ref Zheng, L., Lin, Y., Lu, S., Zhang, J., and Bogdanov, M. 2016. Biogenesis, transport and remodeling of lysophospholipids in Gram-negative bacteria. Biochim Biophys Acta 1862, 1404--1413. Google Scholar Cross Ref
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Most antibiotics are targeted at intracellular processes. Therefore, their effects are determined by an ability to penetrate bacterial membranes. Mechanism of reducing permeability of porin channels in Gram-negative bacteria is the least known one among the possible reasons of antibiotic resistance. The adaptive accumulation of lysophosphatidylethanolamine (LPE), which is observed under conditions typical for the parasitic phase (in particular, the availability of glucose) of Gram-negative bacteria Yersinia pseudotuberculsis is accompanied by rearrangements in conformation of outer membrane protein OmpF that may impede the porin channel permeability for ß-lactam antibiotics. In present study, we report that adaptive accumulation of LPE in membranes of Y. pseudotuberculosis grown in the presence of glucose reduces antibacterial effect of ampicillin. In turn, polyphenol extract from buckwheat husks (PEBH) induces both the decrease in the level of LPE and resistance of bacteria to ampicillin. Therefore, PEBH acts synergistically with ampicillin in vivo by lowering its MICs and therefore can be used as antibiotic adjuvant to improve an antibiotic's ability to cross the outer membrane. These results showed that strategies for regulation of adaptive changes in lipid matrix of bacterial membranes is a new potentially effective way to increase the sensitivity of pathogens to known antibiotics.
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ICBBE '18: Proceedings of the 2018 5th International Conference on Biomedical and Bioinformatics Engineering Effect of Adaptive Changes of Lysophosphatidylethanolamine Content on Ampicillin Resistance of Yersinia Pseudotuberculosis
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