Галерея 3182913

Галерея 3182913

This website uses cookies to ensure you get the best experience on our website. Please accept cookies for optimal performance.

Not already a buyer? Register here.

Watch out for Phishing Sites! Always check the address bar before you login to Public Surplus. The page should be secure (https) and should always say in green "The Public Group LLC" as the example below shows.
Customer Support: support@publicsurplus.com | Copyright 1999-2023 The Public Group, LLC. | All rights reserved.

Dashboard
Publications
Account settings
Log out

Journal List

J Transl Med

v.9; 2011

PMC3182913

Create a new collection

Add to an existing collection

Unable to load your collection due to an error
Please try again

Published online 2011 Sep 13. doi: 10.1186/1479-5876-9-151
Find articles by Dolores J Schendel
1 Department of Internal Medicine III, University of Munich, Campus Großhadern, Munich, Germany
2 Institute of Molecular Immunology, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich, Germany
Received 2011 May 19; Accepted 2011 Sep 13.
Copyright ©2011 Beck et al; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0 ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Rowe JM. Optimal induction and post-remission therapy for AML in first remission. Hematology Am Soc Hematol Educ Program. 2009. pp. 396–405. [ PubMed ] Brune M, Castaigne S, Catalano J, Gehlsen K, Ho AD, Hofmann WK, Hogge DE, Nilsson B, Or R, Romero AI. et al. Improved leukemia-free survival after postconsolidation immunotherapy with histamine dihydrochloride and interleukin-2 in acute myeloid leukemia: results of a randomized phase 3 trial. Blood. 2006; 108 :88–96. doi: 10.1182/blood-2005-10-4073. [ PubMed ] [ CrossRef ] [ Google Scholar ] Kolb HJ. Graft-versus-leukemia effects of transplantation and donor lymphocytes. Blood. 2008; 112 :4371–4383. doi: 10.1182/blood-2008-03-077974. [ PubMed ] [ CrossRef ] [ Google Scholar ] Scheibenbogen C, Letsch A, Thiel E, Schmittel A, Mailaender V, Baerwolf S, Nagorsen D, Keilholz U. CD8 T-cell responses to Wilms tumor gene product WT1 and proteinase 3 in patients with acute myeloid leukemia. Blood. 2002; 100 :2132–2137. doi: 10.1182/blood-2002-01-0163. [ PubMed ] [ CrossRef ] [ Google Scholar ] Schmitt M, Schmitt A, Rojewski MT, Chen J, Giannopoulos K, Fei F, Yu Y, Gotz M, Heyduk M, Ritter G. et al. RHAMM-R3 peptide vaccination in patients with acute myeloid leukemia, myelodysplastic syndrome, and multiple myeloma elicits immunologic and clinical responses. Blood. 2008; 111 :1357–1365. [ PubMed ] [ Google Scholar ] Oka Y, Tsuboi A, Taguchi T, Osaki T, Kyo T, Nakajima H, Elisseeva OA, Oji Y, Kawakami M, Ikegame K. et al. Induction of WT1 (Wilms' tumor gene)-specific cytotoxic T lymphocytes by WT1 peptide vaccine and the resultant cancer regression. Proc Natl Acad Sci USA. 2004; 101 :13885–13890. doi: 10.1073/pnas.0405884101. [ PMC free article ] [ PubMed ] [ CrossRef ] [ Google Scholar ] Rezvani K, Yong AS, Mielke S, Savani BN, Musse L, Superata J, Jafarpour B, Boss C, Barrett AJ. Leukemia-associated antigen-specific T-cell responses following combined PR1 and WT1 peptide vaccination in patients with myeloid malignancies. Blood. 2008; 111 :236–242. doi: 10.1182/blood-2007-08-108241. [ PMC free article ] [ PubMed ] [ CrossRef ] [ Google Scholar ] Keilholz U, Letsch A, Busse A, Asemissen AM, Bauer S, Blau IW, Hofmann WK, Uharek L, Thiel E, Scheibenbogen C. A clinical and immunologic phase 2 trial of Wilms tumor gene product 1 (WT1) peptide vaccination in patients with AML and MDS. Blood. 2009; 113 :6541–6548. doi: 10.1182/blood-2009-02-202598. [ PubMed ] [ CrossRef ] [ Google Scholar ] Van Tendeloo VF, Van de Velde A, Van Driessche A, Cools N, Anguille S, Ladell K, Gostick E, Vermeulen K, Pieters K, Nijs G. et al. Induction of complete and molecular remissions in acute myeloid leukemia by Wilms' tumor 1 antigen-targeted dendritic cell vaccination. Proc Natl Acad Sci USA. 2010; 107 :13824–13829. doi: 10.1073/pnas.1008051107. [ PMC free article ] [ PubMed ] [ CrossRef ] [ Google Scholar ] Banchereau J, Palucka AK. Dendritic cells as therapeutic vaccines against cancer. Nat Rev Immunol. 2005; 5 :296–306. doi: 10.1038/nri1592. [ PubMed ] [ CrossRef ] [ Google Scholar ] Steinman RM, Banchereau J. Taking dendritic cells into medicine. Nature. 2007; 449 :419–426. doi: 10.1038/nature06175. [ PubMed ] [ CrossRef ] [ Google Scholar ] Jonuleit H, Kuhn U, Muller G, Steinbrink K, Paragnik L, Schmitt E, Knop J, Enk AH. Pro-inflammatory cytokines and prostaglandins induce maturation of potent immunostimulatory dendritic cells under fetal calf serum-free conditions. Eur J Immunol. 1997; 27 :3135–3142. doi: 10.1002/eji.1830271209. [ PubMed ] [ CrossRef ] [ Google Scholar ] Sato A, Iwasaki A. Induction of antiviral immunity requires Toll-like receptor signaling in both stromal and dendritic cell compartments. Proc Natl Acad Sci USA. 2004; 101 :16274–16279. doi: 10.1073/pnas.0406268101. [ PMC free article ] [ PubMed ] [ CrossRef ] [ Google Scholar ] Napolitani G, Rinaldi A, Bertoni F, Sallusto F, Lanzavecchia A. Selected Toll-like receptor agonist combinations synergistically trigger a T helper type 1-polarizing program in dendritic cells. Nat Immunol. 2005; 6 :769–776. doi: 10.1038/ni1223. [ PMC free article ] [ PubMed ] [ CrossRef ] [ Google Scholar ] Philbin VJ, Levy O. Immunostimulatory activity of Toll-like receptor 8 agonists towards human leucocytes: basic mechanisms and translational opportunities. Biochem Soc Trans. 2007; 35 :1485–1491. doi: 10.1042/BST0351485. [ PubMed ] [ CrossRef ] [ Google Scholar ] Banchereau J, Steinman RM. Dendritic cells and the control of immunity. Nature. 1998; 392 :245–252. doi: 10.1038/32588. [ PubMed ] [ CrossRef ] [ Google Scholar ] Hemmi H, Kaisho T, Takeuchi O, Sato S, Sanjo H, Hoshino K, Horiuchi T, Tomizawa H, Takeda K, Akira S. Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway. Nat Immunol. 2002; 3 :196–200. doi: 10.1038/ni758. [ PubMed ] [ CrossRef ] [ Google Scholar ] Gautier G, Humbert M, Deauvieau F, Scuiller M, Hiscott J, Bates EE, Trinchieri G, Caux C, Garrone P. A type I interferon autocrine-paracrine loop is involved in Toll-like receptor-induced interleukin-12p70 secretion by dendritic cells. J Exp Med. 2005; 201 :1435–1446. doi: 10.1084/jem.20041964. [ PMC free article ] [ PubMed ] [ CrossRef ] [ Google Scholar ] Gorden KK, Qiu XX, Binsfeld CC, Vasilakos JP, Alkan SS. Cutting edge: activation of murine TLR8 by a combination of imidazoquinoline immune response modifiers and poly T oligodeoxynucleotides. J Immunol. 2006; 177 :6584–6587. [ PubMed ] [ Google Scholar ] Gorden KB, Gorski KS, Gibson SJ, Kedl RM, Kieper WC, Qiu X, Tomai MA, Alkan SS, Vasilakos JP. Synthetic TLR agonists reveal functional differences between human TLR7 and TLR8. J Immunol. 2005; 174 :1259–1268. [ PubMed ] [ Google Scholar ] Alexopoulou L, Holt AC, Medzhitov R, Flavell RA. Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature. 2001; 413 :732–738. doi: 10.1038/35099560. [ PubMed ] [ CrossRef ] [ Google Scholar ] Stahl-Hennig C, Eisenblatter M, Jasny E, Rzehak T, Tenner-Racz K, Trumpfheller C, Salazar AM, Uberla K, Nieto K, Kleinschmidt J. et al. Synthetic double-stranded RNAs are adjuvants for the induction of T helper 1 and humoral immune responses to human papillomavirus in rhesus macaques. PLoS Pathog. 2009; 5 :e1000373. doi: 10.1371/journal.ppat.1000373. [ PMC free article ] [ PubMed ] [ CrossRef ] [ Google Scholar ] Trumpfheller C, Caskey M, Nchinda G, Longhi MP, Mizenina O, Huang Y, Schlesinger SJ, Colonna M, Steinman RM. The microbial mimic poly IC induces durable and protective CD4+ T cell immunity together with a dendritic cell targeted vaccine. Proc Natl Acad Sci USA. 2008; 105 :2574–2579. doi: 10.1073/pnas.0711976105. [ PMC free article ] [ PubMed ] [ CrossRef ] [ Google Scholar ] Blanco P, Palucka AK, Pascual V, Banchereau J. Dendritic cells and cytokines in human inflammatory and autoimmune diseases. Cytokine Growth Factor Rev. 2008; 19 :41–52. doi: 10.1016/j.cytogfr.2007.10.004. [ PMC free article ] [ PubMed ] [ CrossRef ] [ Google Scholar ] Busch DH, Pilip IM, Vijh S, Pamer EG. Coordinate regulation of complex T cell populations responding to bacterial infection. Immunity. 1998; 8 :353–362. doi: 10.1016/S1074-7613(00)80540-3. [ PubMed ] [ CrossRef ] [ Google Scholar ] Dauer M, Obermaier B, Herten J, Haerle C, Pohl K, Rothenfusser S, Schnurr M, Endres S, Eigler A. Mature dendritic cells derived from human monocytes within 48 hours: a novel strategy for dendritic cell differentiation from blood precursors. J Immunol. 2003; 170 :4069–4076. [ PubMed ] [ Google Scholar ] Zobywalski A, Javorovic M, Frankenberger B, Pohla H, Kremmer E, Bigalke I, Schendel DJ. Generation of clinical grade dendritic cells with capacity to produce biologically active IL-12p70. J Transl Med. 2007; 5 :18. doi: 10.1186/1479-5876-5-18. [ PMC free article ] [ PubMed ] [ CrossRef ] [ Google Scholar ] Trinchieri G. Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu Rev Immunol. 1995; 13 :251–276. doi: 10.1146/annurev.iy.13.040195.001343. [ PubMed ] [ CrossRef ] [ Google Scholar ] Hsu FJ, Benike C, Fagnoni F, Liles TM, Czerwinski D, Taidi B, Engleman EG, Levy R. Vaccination of patients with B-cell lymphoma using autologous antigen-pulsed dendritic cells. Nat Med. 1996; 2 :52–58. doi: 10.1038/nm0196-52. [ PubMed ] [ CrossRef ] [ Google Scholar ] De Vries IJ, Krooshoop DJ, Scharenborg NM, Lesterhuis WJ, Diepstra JH, Van Muijen GN, Strijk SP, Ruers TJ, Boerman OC, Oyen WJ. et al. Effective migration of antigen-pulsed dendritic cells to lymph nodes in melanoma patients is determined by their maturation state. Cancer Res. 2003; 63 :12–17. [ PubMed ] [ Google Scholar ] Kawai T, Akira S. Antiviral signaling through pattern recognition receptors. J Biochem. 2007; 141 :137–145. [ PubMed ] [ Google Scholar ] Dauer M, Lam V, Arnold H, Junkmann J, Kiefl R, Bauer C, Schnurr M, Endres S, Eigler A. Combined use of toll-like receptor agonists and prostaglandin E(2) in the FastDC model: rapid generation of human monocyte-derived dendritic cells capable of migration and IL-12p70 production. J Immunol Methods. 2008; 337 :97–105. doi: 10.1016/j.jim.2008.07.003. [ PubMed ] [ CrossRef ] [ Google Scholar ] Larange A, Antonios D, Pallardy M, Kerdine-Römer S. TLR7 and TLR8 agonists trigger different signaling pathways for human dendritic cell maturation. J Leukoc Biol. 2009; 85 :673–83. doi: 10.1189/jlb.0808504. [ PubMed ] [ CrossRef ] [ Google Scholar ] Akira S, Takeda K, Kaisho T. Toll-like receptors: critical proteins linking innate and acquired immunity. Nat Immunol. 2001; 2 :675–680. doi: 10.1038/90609. [ PubMed ] [ CrossRef ] [ Google Scholar ] Iwasaki A, Medzhitov R. Toll-like receptor control of the adaptive immune responses. Nat Immunol. 2004; 5 :987–995. doi: 10.1038/ni1112. [ PubMed ] [ CrossRef ] [ Google Scholar ] Kawai T, Akira S. TLR signaling. Semin Immunol. 2007; 19 :24–32. doi: 10.1016/j.smim.2006.12.004. [ PubMed ] [ CrossRef ] [ Google Scholar ] Spranger S, Javorovic M, Burdek M, Wilde S, Mosetter B, Tippmer S, Bigalke I, Geiger C, Schendel DJ, Frankenberger B. Generation of Th1-polarizing dendritic cells using the TLR7/8 agonist CL075. J Immunol. 2010; 185 :738–747. doi: 10.4049/jimmunol.1000060. [ PubMed ] [ CrossRef ] [ Google Scholar ] Boullart AC, Aarntzen EH, Verdijk P, Jacobs JF, Schuurhuis DH, Benitez-Ribas D, Schreibelt G, van de Rakt MW, Scharenborg NM, de Boer A. et al. Maturation of monocyte-derived dendritic cells with Toll-like receptor 3 and 7/8 ligands combined with prostaglandin E2 results in high interleukin-12 production and cell migration. Cancer Immunol Immunother. 2008; 57 :1589–1597. doi: 10.1007/s00262-008-0489-2. [ PMC free article ] [ PubMed ] [ CrossRef ] [ Google Scholar ] Selenko-Gebauer N, Majdic O, Szekeres A, Hofler G, Guthann E, Korthauer U, Zlabinger G, Steinberger P, Pickl WF, Stockinger H. et al. B7-H1 (programmed death-1 ligand) on dendritic cells is involved in the induction and maintenance of T cell anergy. J Immunol. 2003; 170 :3637–3644. [ PubMed ] [ Google Scholar ] Czerniecki BJ, Koski GK, Koldovsky U, Xu S, Cohen PA, Mick R, Nisen-baum H, Pasha T, Xu M, Fox KR, Weinstein S, Orel SG, Vonderheide R, Coukos G, DeMichele A, Araujo L, Spitz FR, Rosen M, Levine BL, June C, Zhang PJ. Targeting HER-2/neu in early breast cancer development using dendritic cells with staged interleukin-12 burst secretion. Cancer Res. 2007; 67 :1842–52. doi: 10.1158/0008-5472.CAN-06-4038. [ PubMed ] [ CrossRef ] [ Google Scholar ] Roses RE, Xu S, Xu M, Koldovsky U, Koski G, Czerniecki BJ. Differential production of IL-23 and IL-12 by myeloid-derived dendritic cells in response to TLR agonists. J Immunol. 2008; 181 :5120–7. [ PubMed ] [ Google Scholar ] Muranski P, Restifo NP. Adoptive immunotherapy of cancer using CD4(+) T cells. Curr Opin Immunol. 2009; 21 :200–208. doi: 10.1016/j.coi.2009.02.004. [ PMC free article ] [ PubMed ] [ CrossRef ] [ Google Scholar ] Ali OA, Emerich D, Dranoff G, Mooney DJ. In situ regulation of DC subsets and T cells mediates tumor regression in mice. Sci Transl Med. 2009; 1 :8ra19. doi: 10.1126/scitranslmed.3000359. [ PMC free article ] [ PubMed ] [ CrossRef ] [ Google Scholar ] Gutcher I, Becher B. APC-derived cytokines and T cell polarization in autoimmune inflammation. J Clin Invest. 2007; 117 :1119–1127. doi: 10.1172/JCI31720. [ PMC free article ] [ PubMed ] [ CrossRef ] [ Google Scholar ] Lee JJ, Kook H, Park MS, Nam JH, Choi BH, Song WH, Park KS, Lee IK, Chung IJ, Hwang TJ, Kim HJ. Immunotherapy using autologous monocyte-derived dendritic cells pulsed with leukemic cell lysates for acute myeloid leukemia relapse after autologous peripheral blood stem cell transplantation. J Clin Apher. 2004; 19 :66–70. doi: 10.1002/jca.10080. [ PubMed ] [ CrossRef ] [ Google Scholar ] Draube A, Beyer M, Wolf J. Activation of autologous leukemia-specific T cells in acute myeloid leukemia: monocyte-derived dendritic cells cocultured with leukemic blasts compared with leukemia-derived dendritic cells. Eur J Haematol. 2008; 81 :281–288. doi: 10.1111/j.1600-0609.2008.01110.x. [ PubMed ] [ CrossRef ] [ Google Scholar ] Mailliard RB, Wankowicz-Kalinska A, Cai Q, Wesa A, Hilkens CM, Kapsenberg M, Kirkwood JM, Storkus WJ, Kalinski P. alpha-type-1 polarized dendritic cells: a novel immunization tool with optimized CTL-inducing activity. Cancer Research. 2004; 64 :5934–7. doi: 10.1158/0008-5472.CAN-04-1261. [ PubMed ] [ CrossRef ] [ Google Scholar ] Bogunovic D, Manches O, Godefroy E, Yewdall A, Gallois A, Salazar AM, Marie I, Levy DE, Bhardwaj N. TLR4 Engagement during TLR3-Induced Proinflammatory Signaling in Dendritic Cells Promotes IL-10-Mediated Suppression of Antitumor Immunity. Cancer Research. 2011; 71 :5467–76. doi: 10.1158/0008-5472.CAN-10-3988. [ PMC free article ] [ PubMed ] [ CrossRef ] [ Google Scholar ] Cheever MA, Allison JP, Ferris AS, Finn OJ, Hastings BM, Hecht TT, Mellman I, Prindiville SA, Viner JL, Weiner LM, Matrisian LM. The prioritization of cancer antigens: a national cancer institute pilot project for the acceleration of translational research. Clin Cancer Res. 2009; 15 :5323–5337. doi: 10.1158/1078-0432.CCR-09-0737. [ PMC free article ] [ PubMed ] [ CrossRef ] [ Google Scholar ] Rezvani K, Yong AS, Mielke S, Jafarpour B, Savani BN, Le RQ, Eniafe R, Musse L, Boss C, Kurlander R, Barrett AJ. Repeated PR1 and WT1 peptide vaccination in Montanide-adjuvant fails to induce sustained high-avidity, epitope-specific CD8+ T cells in myeloid malignancies. Haematologica. 2011; 96 :432–440. doi: 10.3324/haematol.2010.031674. [ PMC free article ] [ PubMed ] [ CrossRef ] [ Google Scholar ]
Articles from Journal of Translational Medicine are provided here courtesy of BioMed Central
Rowe JM. Optimal induction and post-remission therapy for AML in first remission. Hematology Am Soc Hematol Educ Program. 2009. pp. 396–405. [ PubMed ] [ Ref list ]
Brune M, Castaigne S, Catalano J, Gehlsen K, Ho AD, Hofmann WK, Hogge DE, Nilsson B, Or R, Romero AI. et al. Improved leukemia-free survival after postconsolidation immunotherapy with histamine dihydrochloride and interleukin-2 in acute myeloid leukemia: results of a randomized phase 3 trial. Blood. 2006; 108 :88–96. doi: 10.1182/blood-2005-10-4073. [ PubMed ] [ CrossRef ] [ Google Scholar ] [ Ref list ]
Kolb HJ. Graft-versus-leukemia effects of transplantation and donor lymphocytes. Blood. 2008; 112 :4371–4383. doi: 10.1182/blood-2008-03-077974. [ PubMed ] [ CrossRef ] [ Google Scholar ] [ Ref list ]
Scheibenbogen C, Letsch A, Thiel E, Schmittel A, Mailaender V, Baerwolf S, Nagorsen D, Keilholz U. CD8 T-cell responses to Wilms tumor gene product WT1 and proteinase 3 in patients with acute myeloid leukemia. Blood. 2002; 100 :2132–2137. doi: 10.1182/blood-2002-01-0163. [ PubMed ] [ CrossRef ] [ Google Scholar ] [ Ref list ]
Keilholz U, Letsch A, Busse A, Asemissen AM, Bauer S, Blau IW, Hofmann WK, Uharek L, Thiel E, Scheibenbogen C. A clinical and immunologic phase 2 trial of Wilms tumor gene product 1 (WT1) peptide vaccination in patients with AML and MDS. Blood. 2009; 113 :6541–6548. doi: 10.1182/blood-2009-02-202598. [ PubMed ] [ CrossRef ] [ Google Scholar ] [ Ref list ]
Van Tendeloo VF, Van de Velde A, Van Driessche A, Cools N, Anguille S, Ladell K, Gostick E, Vermeulen K, Pieters K, Nijs G. et al. Induction of complete and molecular remissions in acute myeloid leukemia by Wilms' tumor 1 antigen-targeted dendritic cell vaccination. Proc Natl Acad Sci USA. 2010; 107 :13824–13829. doi: 10.1073/pnas.1008051107. [ PMC free article ] [ PubMed ] [ CrossRef ] [ Google Scholar ] [ Ref list ]
Banchereau J, Palucka AK. Dendritic cells as therapeutic vaccines against cancer. Nat Rev Immunol. 2005; 5 :296–306. doi: 10.1038/nri1592. [ PubMed ] [ CrossRef ] [ Google Scholar ] [ Ref list ]
Steinman RM, Banchereau J. Taking dendritic cells into medicine. Nature. 2007; 449 :419–426. doi: 10.1038/nature06175. [ PubMed ] [ CrossRef ] [ Google Scholar ] [ Ref list ]
Jonuleit H, Kuhn U, Muller G, Steinbrink K, Paragnik L, Schmitt E, Knop J, Enk AH. Pro-inflammatory cytokines and prostaglandins induce maturation of potent immunostimulatory dendritic cells under fetal calf serum-free conditions. Eur J Immunol. 1997; 27 :3135–3142. doi: 10.1002/eji.1830271209. [ PubMed ] [ CrossRef ] [ Google Scholar ] [ Ref list ]
Sato A, Iwasaki A. Induction of antiviral immunity requires Toll-like receptor signaling in both stromal and dendritic cell compartments. Proc Natl Acad Sci USA. 2004; 101 :16274–16279. doi: 10.1073/pnas.0406268101. [ PMC free article ] [ PubMed ] [ CrossRef ] [ Google Scholar ] [ Ref l
Рыжая милфа с красивой грудью соснула хуй у мужа
Знойная рыжеволосая милфа
Большой член в киске красавицы Ариэллы Феррера

Галерея 3182913

Report Page