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v.2011; 2011



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Mediators Inflamm. 2011; 2011: 827565.
Published online 2011 May 25. doi: 10.1155/2011/827565
Find articles by Matthaios Speletas
Find articles by Nikoletta Argentou
Find articles by Konstantinos Ritis
1 Department of Immunology and Histocompatibility, Medical School, University of Thessaly, Biopolis 41110 Larissa, Greece
2 First Department of Internal Medicine, AHEPA Hospital, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece
3 Gastroenterology and Hepatology Division, Hippokration Hospital, Aristotle University of Thessaloniki, 54642 Thessaloniki, Greece
4 Department of Pathology, Hippokration Hospital, 54635 Thessaloniki, Greece
5 First Department of Internal Medicine, Medical School, Democritus University of Thrace, 68100 Alexandroupolis, Greece
*Matthaios Speletas: rg.htu.dem@lepsam
Received 2010 Dec 14; Accepted 2011 Feb 21.
Copyright © 2011 Matthaios Speletas et al.
This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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Articles from Mediators of Inflammation are provided here courtesy of Hindawi Limited
1. Zheng Y, Rudensky AY. Foxp3 in control of the regulatory T cell lineage. Nature Immunology . 2007; 8 (5):457–462. [ PubMed ] [ Google Scholar ] [ Ref list ]
2. Maloy KJ, Powrie F. Regulatory T cells in the control of immune pathology. Nature Immunology . 2001; 2 (9):816–822. [ PubMed ] [ Google Scholar ] [ Ref list ]
3. Kim JM, Rasmussen JP, Rudensky AY. Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice. Nature Immunology . 2007; 8 (2):191–197. [ PubMed ] [ Google Scholar ] [ Ref list ]
4. Jiang S, Camara N, Lombardi G, Lechler RI. Induction of allopeptide-specific human CD4 + CD25 + regulatory T cells ex vivo. Blood . 2003; 102 (6):2180–2186. [ PubMed ] [ Google Scholar ] [ Ref list ]
5. Aandahl EM, Michaëlsson J, Moretto WJ, Hecht FM, Nixon DF. Human CD4 + CD25 + Regulatory T Cells Control T-Cell Responses to Human Immunodeficiency Virus and Cytomegalovirus Antigens. Journal of Virology . 2004; 78 (5):2454–2459. [ PMC free article ] [ PubMed ] [ Google Scholar ] [ Ref list ]
6. Sugimoto K, Ikeda F, Stadanlick J, Nunes FA, Alter HJ, Chang KM. Suppression of HCV-specific T cells without differential hierarchy demonstrated ex vivo in persistent HCV infection. Hepatology . 2003; 38 (6):1437–1448. [ PubMed ] [ Google Scholar ] [ Ref list ]
8. Stoop JN, Van Der Molen RG, Baan CC, et al. Regulatory T cells contribute to the impaired immune response in patients with chronic hepatitis B virus infection. Hepatology . 2005; 41 (4):771–778. [ PubMed ] [ Google Scholar ] [ Ref list ]
9. Xu D, Fu J, Jin L, et al. Circulating and liver resident CD4 + CD25 + regulatory T cells actively influence the antiviral immune response and disease progression in patients with hepatitis B. Journal of Immunology . 2006; 177 (1):739–747. [ PubMed ] [ Google Scholar ] [ Ref list ]
11. Franzese O, Kennedy PTF, Gehring AJ, et al. Modulation of the CD8 + -T-cell response by CD4 + CD25 + regulatory T cells in patients with hepatitis B virus infection. Journal of Virology . 2005; 79 (6):3322–3328. [ PMC free article ] [ PubMed ] [ Google Scholar ] [ Ref list ]
10. Ward SM, Fox BC, Brown PJ, et al. Quantification and localisation of FOXP3+ T lymphocytes and relation to hepatic inflammation during chronic HCV infection. Journal of Hepatology . 2007; 47 (3):316–324. [ PubMed ] [ Google Scholar ] [ Ref list ]
12. Manigold T, Racanelli V. T-cell regulation by CD4 regulatory T cells during hepatitis B and C virus infections: facts and controversies. Lancet Infectious Diseases . 2007; 7 (12):804–813. [ PubMed ] [ Google Scholar ] [ Ref list ]
13. Kerr JFR, Cooksley WGE, Searle J, et al. The nature of piecemeal necrosis in chronic active hepatitis. Lancet . 1979; 2 (8147):827–828. [ PubMed ] [ Google Scholar ] [ Ref list ]
14. Rust C, Gores GJ. Apoptosis and liver disease. American Journal of Medicine . 2000; 108 (7):567–574. [ PubMed ] [ Google Scholar ] [ Ref list ]
15. Jonuleit H, Schmitt E. The regulatory T cell family: distinct subsets and their interrelations. Journal of Immunology . 2003; 171 (12):6323–6327. [ PubMed ] [ Google Scholar ] [ Ref list ]
16. Ishak K, Baptista A, Bianchi L, et al. Histological grading and staging of chronic hepatitis. Journal of Hepatology . 1995; 22 (6):696–699. [ PubMed ] [ Google Scholar ] [ Ref list ]
17. Brunt EM, Janney CG, Di Bisceglie AM, Neuschwander-Tetri BA, Bacon BR. Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions. American Journal of Gastroenterology . 1999; 94 (9):2467–2474. [ PubMed ] [ Google Scholar ] [ Ref list ]
18. Ludwig J, Dickson ER, McDonald GSA. Staging of chronic nonsuppurative destructive cholangitis (syndrome of primary biliary cirrhosis) Virchows Archiv . 1978; 379 (2):103–112. [ PubMed ] [ Google Scholar ] [ Ref list ]
19. Scheuer P. Primary biliary cirrhosis. Proceedings of the Royal Society of Medicine . 1967; 60 (12):1257–1260. [ PMC free article ] [ PubMed ] [ Google Scholar ] [ Ref list ]
20. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2T method. Methods . 2001; 25 (4):402–408. [ PubMed ] [ Google Scholar ] [ Ref list ]
21. Teodoro JG, Branton PE. Regulation of apoptosis by viral gene products. Journal of Virology . 1997; 71 (3):1739–1746. [ PMC free article ] [ PubMed ] [ Google Scholar ] [ Ref list ]
22. Galle PR, Hofmann WJ, Walczak H, et al. Involvement of the CD95 (APO-1/Fas) receptor and ligand in liver damage. Journal of Experimental Medicine . 1995; 182 (5):1223–1230. [ PMC free article ] [ PubMed ] [ Google Scholar ] [ Ref list ]
27. Lee JY, Chae DW, Kim SM, et al. Expression of FasL and perforin/granzyme B mRNA in chronic hepatitis B virus infection. Journal of Viral Hepatitis . 2004; 11 (2):130–135. [ PubMed ] [ Google Scholar ] [ Ref list ]
26. Tagashira M, Yamamoto K, Fujio K, et al. Expression of perforin and Fas ligand mRNA in the liver of viral hepatitis. Journal of Clinical Immunology . 2000; 20 (5):347–353. [ PubMed ] [ Google Scholar ] [ Ref list ]
28. Kern PA, Saghizadeh M, Ong JM, Bosch RJ, Deem R, Simsolo RB. The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase. Journal of Clinical Investigation . 1995; 95 (5):2111–2119. [ PMC free article ] [ PubMed ] [ Google Scholar ] [ Ref list ]
29. Copaci I, Micu L, Voiculescu M. The role of cytokines in non-alcoholic steatohepatitis. A systematic review. Journal of Gastrointestinal and Liver Diseases . 2006; 15 (4):363–373. [ PubMed ] [ Google Scholar ] [ Ref list ]
30. Chen Q, Galleano M, Cederbaum AI. Cytotoxicity and apoptosis produced by arachidonic acid in Hep G2 cells overexpressing human cytochrome P4502E1. Journal of Biological Chemistry . 1997; 272 (23):14532–14541. [ PubMed ] [ Google Scholar ] [ Ref list ]
33. Li Z, Oben JA, Yang S, et al. Norepinephrine regulates hepatic innate immune system in leptin-deficient mice with nonalcoholic steatohepatitis. Hepatology . 2004; 40 (2):434–441. [ PubMed ] [ Google Scholar ] [ Ref list ]
32. Feldstein AE, Can
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