Галерея 3098145

Галерея 3098145

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D R Dantzker et al.

Am Rev Respir Dis .

1986 Dec .

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Dantzker DR, D'Alonzo GE, Bower JS, Popat K, Crevey BJ.
Dantzker DR, et al.
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PMID: 17089876

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Liu SF, Chin CH, Tseng CW, Chen YC, Kuo HC.
Liu SF, et al.
Medicina (Kaunas). 2021 Oct 15;57(10):1110. doi: 10.3390/medicina57101110.
Medicina (Kaunas). 2021.

PMID: 34684147
Free PMC article.

O'Donnell DE, Elbehairy AF, Berton DC, Domnik NJ, Neder JA.
O'Donnell DE, et al.
Front Physiol. 2017 Feb 22;8:82. doi: 10.3389/fphys.2017.00082. eCollection 2017.
Front Physiol. 2017.

PMID: 28275353
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Vogiatzis I, Zakynthinos G, Andrianopoulos V.
Vogiatzis I, et al.
Pulm Med. 2012;2012:634761. doi: 10.1155/2012/634761. Epub 2012 Dec 12.
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PMID: 23365738
Free PMC article.

Zafar MA, Tsuang W, Lach L, Eschenbacher W, Panos RJ.
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Lung. 2013 Apr;191(2):177-82. doi: 10.1007/s00408-012-9443-3. Epub 2013 Jan 3.
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PMID: 23283384

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Int J Chron Obstruct Pulmon Dis. 2011.

PMID: 21660297
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The effect of low level, steady-state exercise on pulmonary gas exchange was studied in 7 patients with severe chronic obstructive pulmonary disease and pulmonary hypertension. Exercise led to a significant fall in the arterial PO2 from 76 +/- 10 to 63 +/- 8 mm Hg, a rise in the arterial PCO2 from 56 +/- 6 to 62 +/- 8 mm Hg, and a fall in the mixed venous PO2 from 38 +/- 2 to 32 +/- 2 mm Hg. There was, however, no significant change in the degree of ventilation-perfusion inequality as quantified by the multiple inert gas technique and no evidence that impaired O2 diffusion was playing a role in the increased hypoxemia. We conclude that the worsening hypoxemia with exercise in patients with severe COPD is due to an inadequate ventilatory response (leading to a rise in arterial PCO2) and the impact of a decreased mixed venous PO2 on the end-capillary PO2 of low VA/Q lung units and shunt.

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