Галерея 2989517
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Галерея 2989517
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G D Diana et al.
J Med Chem .
1985 Jun .
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Diana GD, McKinlay MA, Otto MJ, Akullian V, Oglesby C.
Diana GD, et al.
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The synthesis and evaluation of a series of 3,5-disubstituted isoxazoles as antipicornavirus agents have led to the discovery of several compounds effective in vitro against rhinovirus type 2 and poliovirus type 2. Compound 32 was found more effective than 4',6-dichloroflavan against both viruses and was evaluated orally in mice infected intracerebrally with polio-2. At 31 mg/kg bid, compound 32 showed a 53% survival rate as compared to 22% for the nonmedicated animals.
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