Галерея 2988795

Галерея 2988795
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1985 Jul .

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The envelope gene of HTLV-III, the retrovirus directly linked to AIDS, encodes a protein of 856 amino acids. Our sequence analysis of the cloned HTLV-III (HXB-3) env gene and its comparison with other isolates reveal significant divergence, especially in the external portion of this protein. A large segment of the env gene (1800 bp) was inserted into the expression vector pEV-vrf3, and a corresponding 68 kd protein, which encompasses both the extracellular and the membrane-associated regions of the native protein, was produced in E. coli. Several smaller polypeptides, which appear to be internal initiation products, were also produced. All 50 AIDS patient sera obtained from different locations in the United States specifically recognized the bacterially synthesized envelope proteins, as judged by Western blots. This suggests that these proteins will be useful for the diagnosis of HTLV-III infection and possibly as a vaccine against AIDS.

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Stocks making the biggest moves after hours: Silvergate Capital, MongoDB, Uber and more
Published Wed, Mar 8 2023 5:07 PM EST Updated Wed, Mar 8 2023 5:11 PM EST
Follow your favorite stocks CREATE FREE ACCOUNT
Pavlo Gonchar | Lightrocket | Getty Images
Check out the companies making headlines after the bell.
Uber — The ride-sharing platform's shares gained 2.5% after Bloomberg reported that the company is weighing a potential spinoff of its freight logistics unit.
Silvergate Capital — Shares slid 36% after the company announced it will wind down operations and liquidate Silvergate Bank. The news comes about a week after the bank warned it may not be able to continue operating and follows a series of financial challenges and government investigations in the aftermath of the collapse of FTX, which was a customer of the bank.
MongoDB — Shares of the database platform provider fell 8% after the bell. MongoDB offered weak guidance on revenue, but posted beats on the top and bottom lines for the fourth quarter.
SVB Financial — The financial services company's stock fell 6% after SVB Financial said that it intends to offer $1.25 billion of its common stock and $500 million of depositary shares.
LoanDepot — The mortgage lender's shares fell 2.6% after its fourth-quarter earnings report missed analysts' expectations. The company reported a loss of 46 cents per share and revenue of $169.7 million. Analysts polled by FactSet had estimated an earnings loss of 27 cents per share and revenue of $190.9 million.
Fossil — The fashion accessories company's shares rose 2%. Despite Fossil reporting a 17% drop in revenue for the fourth quarter, shares rose after CEO Kosta Kartsotis stated the company's commitment to improving its financials through its Transform and Grow strategy.
— CNBC's Darla Mercado and Tanaya Macheel contributed reporting
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Галерея 2988795

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