Галерея 2988022
Галерея 2988022
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R A Armstrong et al.
Prostaglandins .
1985 Apr .
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Armstrong RA, Jones RL, Peesapati V, Will SG, Wilson NH.
Armstrong RA, et al.
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Adv Exp Med Biol. 1985;192:67-81. doi: 10.1007/978-1-4615-9442-0_6.
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Review.
No abstract available.
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Circulation. 1980 Dec;62(6 Pt 2):V19-25.
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Review.
Braune S, Küpper JH, Jung F.
Braune S, et al.
Int J Mol Sci. 2020 Nov 27;21(23):9020. doi: 10.3390/ijms21239020.
Int J Mol Sci. 2020.
PMID: 33260972
Free PMC article.
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Crescente M, Menke L, Chan MV, Armstrong PC, Warner TD.
Crescente M, et al.
Br J Pharmacol. 2019 Apr;176(8):988-999. doi: 10.1111/bph.14196. Epub 2018 Apr 19.
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PMID: 29512148
Free PMC article.
Review.
Colas RA, Ashton AW, Mukherjee S, Dalli J, Akide-Ndunge OB, Huang H, Desruisseaux MS, Guan F, Jelicks LA, Matos Dos Santos F, Nagajyothi J, Zingman MA, Reyes J, Weiss LM, Serhan CN, Tanowitz HB.
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Free PMC article.
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The inhibition of human platelet aggregation produced by PGF2 alpha is not specific for thromboxane A2 mimetics. Aggregation waves induced by PAF and thrombin are also inhibited by PGF2 alpha (8 microM); ADP is unaffected. These effects are still seen in platelets from aspirin-treated donors and platelets desensitized to thromboxane-like agonists (e.g. 11,9-epoxymethano PGH2). In contrast the thromboxane receptor antagonist EP 045 (up to 20 microM) had no effect on primary aggregation induced by PAF, thrombin and ADP. We have previously shown that EP 045 (IC50 = 0.5 microM), but not PGF2 alpha (28 microM), displaces the specific binding of [3H] 9,11-epoxymethano PGH2 to washed human platelets. PGF2 alpha produces small increases in cAMP levels, and both this effect and the anti-aggregation are diminished by the adenyl cyclase inhibitor SQ 22536. The rise in cAMP induced by PGF2 alpha is inhibited to a greater extent by the presence of ADP than by thrombin, PAF or a thromboxane mimetic. The ability of aggregating agents to inhibit this increase correlates inversely with their sensitivity to inhibition by PGF2 alpha. We suggest that the very weak effect of PGF2 alpha on cyclic AMP production is sufficient to account for its inhibitory activity, and it is unlikely to be a competitive antagonist at the platelet thromboxane receptor as suggested by others.
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Очкастый ботан и соблазнительная пантера
Темнокожая Афина показала
Сексуальная телка стимулирует член парня своими красивыми ножками