Галерея 2982573
Галерея 2982573
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C D Scott et al.
Endocrinology .
1985 Mar .
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Bick T, Amit T, Barkey RJ, Hertz P, Youdim MB, Hochberg Z.
Bick T, et al.
Endocrinology. 1990 Apr;126(4):1914-20. doi: 10.1210/endo-126-4-1914.
Endocrinology. 1990.
PMID: 2318149
Maiter D, Walker JL, Adam E, Moatsstaats B, Mulumba N, Ketelslegers JM, Underwood LE.
Maiter D, et al.
Endocrinology. 1992 Jun;130(6):3257-64. doi: 10.1210/endo.130.6.1375898.
Endocrinology. 1992.
PMID: 1375898
Maiter D, Underwood LE, Maes M, Davenport ML, Ketelslegers JM.
Maiter D, et al.
Endocrinology. 1988 Aug;123(2):1053-9. doi: 10.1210/endo-123-2-1053.
Endocrinology. 1988.
PMID: 3396497
Herington AC, Cornell HJ, Kuffer AD.
Herington AC, et al.
Int J Biochem. 1983;15(10):1201-10. doi: 10.1016/0020-711x(83)90208-2.
Int J Biochem. 1983.
PMID: 6313443
Review.
Daughaday WH.
Daughaday WH.
Pediatr Nephrol. 2000 Jul;14(7):537-40. doi: 10.1007/s004670000334.
Pediatr Nephrol. 2000.
PMID: 10912514
Review.
Chen Y, Wang J, Li S, Li Y.
Chen Y, et al.
Heliyon. 2022 Oct 14;8(10):e11051. doi: 10.1016/j.heliyon.2022.e11051. eCollection 2022 Oct.
Heliyon. 2022.
PMID: 36281415
Free PMC article.
Lapadula D, Lam B, Terai M, Sugase T, Tanaka R, Farias E, Kadamb R, Lopez-Anton M, Heine CC, Modasia B, Aguirre-Ghiso JA, Aplin AE, Sato T, Benovic JL.
Lapadula D, et al.
Mol Cancer Ther. 2023 Jan 3;22(1):63-74. doi: 10.1158/1535-7163.MCT-22-0147.
Mol Cancer Ther. 2023.
PMID: 36223548
Yinghao L, Jing Y, Yongqi W, Jianming Z, Zeng G, Yiting T, Shuoqi L.
Yinghao L, et al.
J Int Med Res. 2021 Sep;49(9):3000605211039564. doi: 10.1177/03000605211039564.
J Int Med Res. 2021.
PMID: 34486432
Free PMC article.
Clinical Trial.
Sobrevals L, Enguita M, Quiroga J, Prieto J, Fortes P.
Sobrevals L, et al.
PLoS One. 2016 Sep 22;11(9):e0162955. doi: 10.1371/journal.pone.0162955. eCollection 2016.
PLoS One. 2016.
PMID: 27658043
Free PMC article.
Ishikawa M, Tachibana T, Yoshino G, Hashimoto H, Tanaka T.
Ishikawa M, et al.
Hum Cell. 2010 Nov;23(4):164-72. doi: 10.1111/j.1749-0774.2010.00097.x.
Hum Cell. 2010.
PMID: 21166888
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This study examines the regulation of insulin-like growth factor I (IGF I) and binding protein (BP) release by adult rat hepatocytes in primary culture. Increasing the density of plating of cells had a marked positive effect on the IGF I production rate per mg cell protein, with the highest rate, approximately 4 pmol/mg cell protein X 24 h, seen at densities of 1 X 10(5) cells/cm2 or higher. Cycloheximide (15 micrograms/ml) inhibited both IGF I and BP production by more than 90%, while actinomycin D (0.1 microgram/ml) caused less marked, but still significant, inhibition. Over the insulin range 30 pM-300 nM there was a 45% increase in IGF I production, but no effect on BP production. Bovine GH stimulated production of both peptides, significant effects (up to 50% stimulation) being seen at concentrations from 20-500 ng/ml. Cells from hypophysectomized rats, with serum IGF I and GH levels reduced more than 90% from normal, had IGF I and BP production rates only 7% of normal, measured after 48 h in culture. In vivo replacement with rat GH, 150 micrograms/day for 5 days by osmotic minipump, significantly restored the production of both peptides by hepatocytes. Cells isolated from rats bearing the GH-secreting tumor, MtT/W15, had IGF I and BP production rates approximately twice as high as normal. A significant stimulatory effect of bovine GH (200 ng/ml) in vitro was seen on cells from normal and hypophysectomized, GH-replaced rats, but not from unreplaced hypophysectomized, or tumor-bearing rats. The results in hypophysectomized, animals are consistent with known changes in hepatic GH receptors, while the lack of GH responsiveness in tumor-bearing rats indicates a persistence of maximal stimulation in culture. The reflection of in vivo GH status by hepatocytes cultured for 48 h suggests that messenger RNA turnover for IGF I and BP must be slow. The close parallel in the regulation of the two peptides under most conditions might be indicative of coordinated synthesis.
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