Галерея 2929287

Галерея 2929287




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Галерея 2929287

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Nat Rev Clin Oncol. Author manuscript; available in PMC 2010 Nov 1.
Deric L. Wheeler, Department of Human Oncology, University of Wisconsin Comprehensive Cancer Center, 1111 Highland Avenue Madison, WI 53705, USA;
Correspondence to: D. L. Wheeler ude.csiw@releehwld
The publisher's final edited version of this article is available at Nat Rev Clin Oncol
1. Cohen S. Isolation of a mouse submaxillary gland protein accelerating incisor eruption and eyelid opening in the new-born animal. J. Biol. Chem. 1962; 237 :1555–1562. [ PubMed ] [ Google Scholar ]
2. Cohen S. The stimulation of epidermal proliferation by a specific protein (EGF) Dev. Biol. 1965; 12 :394–407. [ PubMed ] [ Google Scholar ]
3. Carpenter G, Lembach KJ, Morrison MM, Cohen S. Characterization of the binding of 125-I-labeled epidermal growth factor to human fibroblasts. J. Biol. Chem. 1975; 250 :4297–4304. [ PubMed ] [ Google Scholar ]
4. Carpenter G, King L, Jr, Cohen S. Epidermal growth factor stimulates phosphorylation in membrane preparations in vitro . Nature. 1978; 276 :409–410. [ PubMed ] [ Google Scholar ]
5. Ullrich A, et al. Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells. Nature. 1984; 309 :418–425. [ PubMed ] [ Google Scholar ]
6. Eckhart W, Hutchinson MA, Hunter T. An activity phosphorylating tyrosine in polyoma T antigen immunoprecipitates. Cell. 1979; 18 :925–933. [ PubMed ] [ Google Scholar ]
7. Hunter T, Sefton BM. Transforming gene product of Rous sarcoma virus phosphorylates tyrosine. Proc. Natl Acad. Sci. USA. 1980; 77 :1311–1315. [ PMC free article ] [ PubMed ] [ Google Scholar ]
8. Yarden Y, Sliwkowski MX. Untangling the ErbB signalling network. Nat. Rev. Mol. Cell Biol. 2001; 2 :127–137. [ PubMed ] [ Google Scholar ]
9. Marmor MD, Skaria KB, Yarden Y. Signal transduction and oncogenesis by ErbB/HER receptors. Int. J. Radiat. Oncol. Biol. Phys. 2004; 58 :903–913. [ PubMed ] [ Google Scholar ]
10. Libermann TA, et al. Expression of epidermal growth factor receptors in human brain tumors. Cancer Res. 1984; 44 :753–760. [ PubMed ] [ Google Scholar ]
11. Libermann TA, et al. Amplification, enhanced expression and possible rearrangement of EGF receptor gene in primary human brain tumours of glial origin. Nature. 1985; 313 :144–147. [ PubMed ] [ Google Scholar ]
12. Libermann TA, et al. Amplification and overexpression of the EGF receptor gene in primary human glioblastomas. J. Cell Sci. Suppl. 1985; 3 :161–172. [ PubMed ] [ Google Scholar ]
13. Veale D, Ashcroft T, Marsh C, Gibson GJ, Harris AL. Epidermal growth factor receptors in non-small cell lung cancer. Br. J. Cancer. 1987; 55 :513–516. [ PMC free article ] [ PubMed ] [ Google Scholar ]
14. Weichselbaum RR, et al. Epidermal growth factor receptor gene amplification and expression in head and neck cancer cell lines. Head Neck. 1989; 11 :437–442. [ PubMed ] [ Google Scholar ]
15. Sato JD, et al. Biological effects in vitro of monoclonal antibodies to human epidermal growth factor receptors. Mol. Biol. Med. 1983; 1 :511–529. [ PubMed ] [ Google Scholar ]
16. Kawamoto T, et al. Growth stimulation of A431 cells by epidermal growth factor: identification of high-affinity receptors for epidermal growth factor by an anti-receptor monoclonal antibody. Proc. Natl Acad. Sci. USA. 1983; 80 :1337–1341. [ PMC free article ] [ PubMed ] [ Google Scholar ]
17. Honegger AM, et al. Point mutation at the ATP binding site of EGF receptor abolishes protein-tyrosine kinase activity and alters cellular routing. Cell. 1987; 51 :199–209. [ PubMed ] [ Google Scholar ]
18. Honegger AM, et al. A mutant epidermal growth factor receptor with defective protein tyrosine kinase is unable to stimulate proto-oncogene expression and DNA synthesis. Mol. Cell. Biol. 1987; 7 :4568–4571. [ PMC free article ] [ PubMed ] [ Google Scholar ]
19. Redemann N, et al. Anti-oncogenic activity of signalling-defective epidermal growth factor receptor mutants. Mol. Cell. Biol. 1992; 12 :491–498. [ PMC free article ] [ PubMed ] [ Google Scholar ]
20. Fry DW, et al. A specific inhibitor of the epidermal growth factor receptor tyrosine kinase. Science. 1994; 265 :1093–1095. [ PubMed ] [ Google Scholar ]
21. Osherov N, Levitzki A. Epidermal-growth-factor-dependent activation of the src-family kinases. Eur. J. Biochem. 1994; 225 :1047–1053. [ PubMed ] [ Google Scholar ]
22. Wakeling AE, et al. Specific inhibition of epidermal growth factor receptor tyrosine kinase by 4-anilinoquinazolines. Breast Cancer Res. Treat. 1996; 38 :67–73. [ PubMed ] [ Google Scholar ]
23. Bonner JA, et al. Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck. N. Engl. J. Med. 2006; 354 :567–578. [ PubMed ] [ Google Scholar ]
24. Herbst RS, et al. Gefitinib in combination with paclitaxel and carboplatin in advanced non-small-cell lung cancer: a phase III trial—INTACT 2. J. Clin. Oncol. 2004; 22 :785–794. [ PubMed ] [ Google Scholar ]
25. Thatcher N, et al. Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: results from a randomised, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer) Lancet. 2005; 366 :1527–1537. [ PubMed ] [ Google Scholar ]
26. Borner M, et al. Adding cetuximab to capecitabine plus oxaliplatin (XELOX) in first-line treatment of metastatic colorectal cancer: a randomized phase II trial of the Swiss Group for Clinical Cancer Research SAKK. Ann. Oncol. 2008; 19 :1288–1292. [ PubMed ] [ Google Scholar ]
27. Sobrero AF, et al. EPIC: phase III trial of cetuximab plus irinotecan after fluoropyrimidine and oxaliplatin failure in patients with metastatic colorectal cancer. J. Clin. Oncol. 2008; 26 :2311–2319. [ PubMed ] [ Google Scholar ]
28. Moore MJ, et al. Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group. J. Clin. Oncol. 2007; 25 :1960–1966. [ PubMed ] [ Google Scholar ]
29. Senderowicz AM, et al. Erlotinib/gemcitabine for first-line treatment of locally advanced or metastatic adenocarcinoma of the pancreas. Oncology (Williston Park) 2007; 21 :1696–1706. [ PubMed ] [ Google Scholar ]
30. Di Leo A, et al. Phase III, double-blind, randomized study comparing lapatinib plus paclitaxel with placebo plus paclitaxel as first-line treatment for metastatic breast cancer. J. Clin. Oncol. 2008; 26 :5544–5552. [ PMC free article ] [ PubMed ] [ Google Scholar ]
31. Jackman D, et al. Clinical definition of acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small-cell lung cancer. J. Clin. Oncol. 2010; 28 :357–360. [ PMC free article ] [ PubMed ] [ Google Scholar ]
32. Hynes NE, Lane HA. ERBB receptors and cancer: the complexity of targeted inhibitors. Nat. Rev. Cancer. 2005; 5 :341–354. [ PubMed ] [ Google Scholar ]
33. Klapper LN, et al. The ErbB-2/HER2 oncoprotein of human carcinomas may function solely as a shared coreceptor for multiple stroma-derived growth factors. Proc. Natl Acad. Sci. USA. 1999; 96 :4995–5000. [ PMC free article ] [ PubMed ] [ Google Scholar ]
34. Baselga J, Swain SM. Novel anticancer targets: revisiting ERBB2 and discovering ERBB3. Nat. Rev. Cancer. 2009; 9 :463–475. [ PubMed ] [ Google Scholar ]
35. Guy PM, Platko JV, Cantley LC, Cerione RA, Carraway KL., 3rd Insect cell-expressed p180erbB3 possesses an impaired tyrosine kinase activity. Proc. Natl Acad. Sci. USA. 1994; 91 :8132–8136. [ PMC free article ] [ PubMed ] [ Google Scholar ]
36. Wallasch C, et al. Heregulin-dependent regulation of HER2/neu oncogenic signaling by heterodimerization with HER3. EMBO J. 1995; 14 :4267–4275. [ PMC free article ] [ PubMed ] [ Google Scholar ]
37. Weihua Z, et al. Survival of cancer cells is maintained by EGFR independent of its kinase activity. Cancer Cell. 2008; 13 :385–393. [ PMC free article ] [ PubMed ] [ Google Scholar ]
38. Marti U, et al. Localization of epidermal growth factor receptor in hepatocyte nuclei. Hepatology. 1991; 13 :15–20. [ PubMed ] [ Google Scholar ]
39. Cao H, Lei ZM, Bian L, Rao CV. Functional nuclear epidermal growth factor receptors in human choriocarcinoma JEG-3 cells and normal human placenta. Endocrinology. 1995; 136 :3163–3172. [ PubMed ] [ Google Scholar ]
40. Lin SY, et al. Nuclear localization of EGF receptor and its potential new role as a transcription factor. Nat. Cell Biol. 2001; 3 :802–808. [ PubMed ] [ Google Scholar ]
41. Lo HW, Hsu SC, Hung MC. EGFR signaling pathway in breast cancers: from traditional signal transduction to direct nuclear translocalization. Breast Cancer Res. Treat. 2006; 95 :211–218. [ PubMed ] [ Google Scholar ]
42. Lo HW, Hung MC. Nuclear EGFR signalling network in cancers: linking EGFR pathway to cell cycle progression, nitric oxide pathway and patient survival. Br. J. Cancer. 2006; 94 :184–188. [ PMC free article ] [ PubMed ] [ Google Scholar ]
43. Lo HW, et al. Novel prognostic value of nuclear epidermal growth factor receptor in breast cancer. Cancer Res. 2005; 65 :338–348. [ PubMed ] [ Google Scholar ]
44. Psyrri A, et al. Quantitative determination of nuclear and cytoplasmic epidermal growth factor receptor expression in oropharyngeal squamous cell cancer by using automated quantitative analysis. Clin. Cancer Res. 2005; 11 :5856–5862. [ PubMed ] [ Google Scholar ]
45. Xia W, et al. Nuclear expression of epidermal growth factor receptor is a novel prognostic value in patients with ovarian cancer. Mol. Carcinog. 2009; 48 :610–617. [ PMC free article ] [ PubMed ] [ Google Scholar ]
46. Hanada N, et al. Co-regulation of B-Myb expression by E2F1 and EGF receptor. Mol. Carcinog. 2006; 45 :10–17. [ PubMed ] [ Google Scholar ]
47. Lo HW, et al. Nuclear interaction of EGFR and STAT3 in the activation of the iNOS/NO pathway. Cancer Cell. 2005; 7 :575–589. [ PubMed ] [ Google Scholar ]
48. Lo HW, Cao X, Zhu H, Ali-Osman F. Cyclooxygenase-2 is a novel transcriptional target of the nuclear EGFR-STAT3 and EGFRvIII-STAT3 signaling axes. Mol. Cancer Res. 2010; 8 :232–245. [ PMC free article ] [ PubMed ] [ Google Scholar ]
49. Hsu SC, Hung MC. Characterization of a novel tripartite nuclear localization sequence in the EGFR family. J. Biol. Chem. 2007; 282 :10432–10440. [ PubMed ] [ Google Scholar ]
50. Lo HW, et al. Nuclear-cytoplasmic transport of EGFR involves receptor endocytosis, importin beta1 and CRM1. J. Cell. Biochem. 2006; 98 :1570–1583. [ PubMed ] [ Google Scholar ]
51. Liao HJ, Carpenter G. Role of the Sec61 translocon in EGF receptor trafficking to the nucleus and gene expression. Mol. Biol. Cell. 2007; 18 :1064–1072. [ PMC free article ] [ PubMed ] [ Google Scholar ]
52. Hung LY, et al. Nuclear epidermal growth factor receptor (EGFR) interacts with signal transducer and activator of transcription 5 (STAT5) in activating Aurora-A gene expression. Nucleic Acids Res. 2008; 36 :4337–4351. [ PMC free article ] [ PubMed ] [ Google Scholar ]
53. Wang SC, et al. Tyrosine phosphorylation controls PCNA function through protein stability. Nat. Cell Biol. 2006; 8 :1359–1368. [ PubMed ] [ Google Scholar ]
54. Goldstein NI, Prewett M, Zuklys K, Rockwell P, Mendelsohn J. Biological efficacy of a chimeric antibody to the epidermal growth factor receptor in a human tumor xenograft model. Clin. Cancer Res. 1995; 1 :1311–1318. [ PubMed ] [ Google Scholar ]
55. Kimura H, et al. Antibody-dependent cellular cytotoxicity of cetuximab against tumor cells with wild-type or mutant epidermal growth factor receptor. Cancer Sci. 2007; 98 :1275–1280. [ PubMed ] [ Google Scholar ]
56. Van Cutsem E, et al. Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer. N. Engl. J. Med. 2009; 360 :1408–1417. [ PubMed ] [ Google Scholar ]
57. Saltz LB, et al. Randomized phase II trial of cetuximab, bevacizumab, and irinotecan compared with cetuximab and bevacizumab alone in irinotecan-refractory colorectal cancer: the BOND-2 study. J. Clin. Oncol. 2007; 25 :4557–4561. [ PubMed ] [ Google Scholar ]
58. Jonker DJ, et al. Cetuximab for the treatment of colorectal cancer. N. Engl. J. Med. 2007; 357 :2040–2048. [ PubMed ] [ Google Scholar ]
59. Cunningham D, et al. Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer. N. Engl. J. Med. 2004; 351 :337–345. [ PubMed ] [ Google Scholar ]
60. Vermorken JB, et al. Platinum-based chemotherapy plus cetuximab in head and neck cancer. N. Engl. J. Med. 2008; 359 :1116–1127. [ PubMed ] [ Google Scholar ]
61. Burtness B, Goldwasser MA, Flood W, Mattar B, Forastiere AA. Phase III randomized trial of cisplatin plus placebo compared with cisplatin plus cetuximab in metastatic/recurrent head and neck cancer: an Eastern Cooperative Oncology Group study. J. Clin. Oncol. 2005; 23 :8646–8654. [ PubMed ] [ Google Scholar ]
62. Yang XD, Jia XC, Corvalan JR, Wang P, Davis CG. Development of ABX-EGF, a fully human anti-EGF receptor monoclonal antibody, for cancer therapy. Crit. Rev. Oncol. Hematol. 2001; 38 :17–23. [ PubMed ] [ Google Scholar ]
63. Yang XD, et al. Eradication of established tumors by a fully human monoclonal antibody to the epidermal growth factor receptor without concomitant chemotherapy. Cancer Res. 1999; 59 :1236–1243. [ PubMed ] [ Google Scholar ]
64. Hecht JR, et al. A randomized phase IIIB trial of chemotherapy, bevacizumab, and panitumumab compared with chemotherapy and bevacizumab alone for metastatic colorectal cancer. J. Clin. Oncol. 2009; 27 :672–680. [ PubMed ] [ Google Scholar ]
65. Giusti RM, et al. U.S. Food and Drug Administration approval: panitumumab for epidermal growth factor receptor-expressing metastatic colorectal carcinoma with progression following fluoropyrimidine-, oxaliplatin-, and irinotecan-containing chemotherapy regimens. Clin. Cancer Res. 2008; 14 :1296–1302. [ PubMed ] [ Google Scholar ]
66. Van Cutsem E, et al. Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy-refractory metastatic colorectal cancer. J. Clin. Oncol. 2007; 25 :1658–1664. [ PubMed ] [ Google Scholar ]
67. Kris MG, et al. Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer: a randomized trial. JAMA. 2003; 290 :2149–2158. [ PubMed ] [ Google Scholar ]
68. Fukuoka M, et al. Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer (The IDEAL 1 Trial) J. Clin. Oncol. 2003; 21 :2237–2246. [ PubMed ] [ Google Scholar ]
69. Giaccone G, et al. Gefitinib in combination with gemcitabine and cisplatin in advanced non-small-cell lung cancer: a phase III trial—INTACT 1. J. Clin. Oncol. 2004; 22 :777–784. [ PubMed ] [ Google Scholar ]
70. Herbst RS, et al. TRIBUTE: a phase III trial of erlotinib hydrochloride (OSI-774) combined with carboplatin and paclitaxel chemotherapy in advanced non-small-cell lung cancer. J. Clin. Oncol. 2005; 23 :5892–5899. [ PubMed ] [ Google Scholar ]
71. Gatzemeier U, et al. Phase III study of erlotinib in combination with cisplatin and gemcitabine in advanced non-small-cell lung cancer: the Tarceva Lung Cancer Investigation Trial. J. Clin. Oncol. 2007; 25 :1545–1552. [ PubMed ] [ Google Scholar ]
72. Shepherd FA, et al. Erlotinib in previously treated non-small-cell lung cancer. N. Engl. J. Med. 2005; 353 :123–132. [ PubMed ] [ Google Scholar ]
73. Tsao MS, et al. Erlotinib in lung cancer—molecular and clinical predictors of outcome. N. Engl. J. Med. 2005; 353 :133–144. [ PubMed ] [ Google Scholar ]
74. Paez JG, et al. EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science. 2004; 304 :1497–1500. [ PubMed ] [ Google Scholar ]
75. Lynch TJ, et al. Activating mutations in the epidermal growth factor r
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