Галерея 2792142
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Галерея 2792142
Copyright Journal compilation © 2009 Blackwell Publishing Ltd
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γδ T cells are unresponsive to standard T-cell receptor stimulation via CD3/C28. (a) Box plot of proliferation index PI (−) of CD4 + T cells ( n = 6), CD8 + T cells ( n = 5), CD4 + CD25 + T cells ( n = 5) and γδ T cells ( n = 10) after stimulation via anti-CD3/CD28 (white boxes) and anti-CD3/CD28 + recombinant human interleukin-2 (rhuIL-2; grey boxes) and (b) bar chart (+ SEM) of PI (−) of CD4 + , CD8 + , γδ and CD4 + CD25 + T cells after stimulation with isopentenyl pyrophosphate + rhuIL-2. (NS, statistically not significant).
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1 Istituto Neurologico C. Besta, Milano, Italia.
V Scaioli et al.
Eur Neurol .
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1 Istituto Neurologico C. Besta, Milano, Italia.
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Brainstem auditory evoked potentials (BAEPs) were evaluated in a series of 15 patients with extra-axial cerebello-pontine angle tumors (3 cases), demyelinating plaques (11 cases), and intra-axial tumor (1 case), verified by magnetic resonance imaging (MRI). A satisfactory correlation between the location of the lesions and the type of BAEP abnormalities was found in 11 cases. In 2 other cases, definite MRI brainstem lesions located outside the acoustic pathways were associated with normal BAEPs. In the opposite situation (2 cases of BAEP abnormalities with normal MRI), the inability of MRI to detect demyelinating lesions may be due to the temporal evolution of the lesions themselves. The results of this BAEP-MRI comparative study confirm that BAEP is a sensitive diagnostic tool in revealing brainstem dysfunction, although its localizing power appears to be debatable. The most satisfactory MRI/BAEP topodiagnostic correlation was found with lesions involving the acoustic nerve in its intracranial tract or the caudal pons and bulbopontine junctions.
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