Галерея 2790163

Галерея 2790163




🛑 ПОДРОБНЕЕ ЖМИТЕ ЗДЕСЬ 👈🏻👈🏻👈🏻

































Галерея 2790163

Amphoe Mueang Rayong ist ein Landkreis in der Provinz Rayong. Die Provinz Rayong liegt im Osten der Zentralregion von Thailand. Wikipedia


Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue


Terms of Use
|
Privacy Policy
|
Accessibility Statement


2023 American Medical Association. All Rights Reserved

Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry

Top of Article

Key Points
Abstract
Introduction
Methods
Results
Discussion
Conclusions
Article Information
References



Figure 1. Data on Low-Density Lipoprotein (LDL) Cholesterol Levels and Healthy Lifestyle in the Case-Control Study (N = 10 175)
Figure 2. Risk of Coronary Artery Disease by Familial Hypercholesterolemia (FH) Variant Carrier Status and Adherence to Healthy Lifestyle in the Case-Control Study (N = 10 175)
Figure 3. Probability of Coronary Artery Disease (CAD) by Familial Hypercholesterolemia (FH) Variant Carrier Status and Adherence to Healthy Lifestyle in the Cohort Study (N = 39 920)
Table 1. Characteristics of Coronary Artery Disease Cases and Controls in the Case-Control Study
Table 2. Characteristics of FH Variant Carriers and Noncarriers in the Cohort Study
Sturm
 AC, Knowles
 JW, Gidding
 SS,
 et al; Convened by the Familial Hypercholesterolemia Foundation. Clinical genetic testing for familial hypercholesterolemia: JACC Scientific Expert Panel.  J Am Coll Cardiol . 2018;72(6):662-680. doi: 10.1016/j.jacc.2018.05.044 PubMed Google Scholar Crossref
Kastelein
 JJP, Reeskamp
 LF, Hovingh
 GK. Familial hypercholesterolemia: the most common monogenic disorder in humans.  J Am Coll Cardiol . 2020;75(20):2567-2569. doi: 10.1016/j.jacc.2020.03.058 PubMed Google Scholar Crossref
Khera
 AV, Won
 HH, Peloso
 GM,
 et al. Diagnostic yield and clinical utility of sequencing familial hypercholesterolemia genes in patients with severe hypercholesterolemia.  J Am Coll Cardiol . 2016;67(22):2578-2589. doi: 10.1016/j.jacc.2016.03.520 PubMed Google Scholar Crossref
Khera
 AV, Chaffin
 M, Zekavat
 SM,
 et al. Whole-genome sequencing to characterize monogenic and polygenic contributions in patients hospitalized with early-onset myocardial infarction.  Circulation . 2019;139(13):1593-1602. doi: 10.1161/CIRCULATIONAHA.118.035658 PubMed Google Scholar Crossref
Patel
 AP, Wang
 M, Fahed
 AC,
 et al. Association of rare pathogenic DNA variants for familial hypercholesterolemia, hereditary breast and ovarian cancer syndrome, and Lynch syndrome with disease risk in adults according to family history.  JAMA Netw Open . 2020;3(4):e203959. doi: 10.1001/jamanetworkopen.2020.3959 Article PubMed Google Scholar
Trinder
 M, Francis
 GA, Brunham
 LR. Association of monogenic vs polygenic hypercholesterolemia with risk of atherosclerotic cardiovascular disease.  JAMA Cardiol . 2020;5(4):390-399. doi: 10.1001/jamacardio.2019.5954 Article PubMed Google Scholar Crossref
Abul-Husn
 NS, Manickam
 K, Jones
 LK,
 et al. Genetic identification of familial hypercholesterolemia within a single U.S. health care system.  Science . 2016;354(6319):aaf7000. doi: 10.1126/science.aaf7000 PubMed Google Scholar
Beheshti
 SO, Madsen
 CM, Varbo
 A, Nordestgaard
 BG. Worldwide prevalence of familial hypercholesterolemia: meta-analyses of 11 million subjects.  J Am Coll Cardiol . 2020;75(20):2553-2566. doi: 10.1016/j.jacc.2020.03.057 PubMed Google Scholar Crossref
Nordestgaard
 BG, Chapman
 MJ, Humphries
 SE,
 et al; European Atherosclerosis Society Consensus Panel. Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: guidance for clinicians to prevent coronary heart disease: consensus statement of the European Atherosclerosis Society.  Eur Heart J . 2013;34(45):3478-90a. doi: 10.1093/eurheartj/eht273 PubMed Google Scholar Crossref
Campbell-Salome
 G, Jones
 LK, Masnick
 MF,
 et al. Developing and optimizing innovative tools to address familial hypercholesterolemia underdiagnosis: identification methods, patient activation, and cascade testing for familial hypercholesterolemia.  Circ Genom Precis Med . 2021;14(1):e003120. doi: 10.1161/CIRCGEN.120.003120 PubMed Google Scholar
deGoma
 EM, Ahmad
 ZS, O’Brien
 EC,
 et al. Treatment gaps in adults with heterozygous familial hypercholesterolemia in the United States: data from the CASCADE-FH Registry.  Circ Cardiovasc Genet . 2016;9(3):240-249. doi: 10.1161/CIRCGENETICS.116.001381 PubMed Google Scholar Crossref
Yu
 E, Malik
 VS, Hu
 FB. Cardiovascular disease prevention by diet modification: JACC Health Promotion Series.  J Am Coll Cardiol . 2018;72(8):914-926. doi: 10.1016/j.jacc.2018.02.085 PubMed Google Scholar Crossref
Lavie
 CJ, Laddu
 D, Arena
 R, Ortega
 FB, Alpert
 MA, Kushner
 RF. Healthy weight and obesity prevention: JACC Health Promotion Series.  J Am Coll Cardiol . 2018;72(13):1506-1531. doi: 10.1016/j.jacc.2018.08.1037 PubMed Google Scholar Crossref
Fletcher
 GF, Landolfo
 C, Niebauer
 J, Ozemek
 C, Arena
 R, Lavie
 CJ. Promoting physical activity and exercise: JACC Health Promotion Series.  J Am Coll Cardiol . 2018;72(14):1622-1639. doi: 10.1016/j.jacc.2018.08.2141 PubMed Google Scholar Crossref
Arnett
 DK, Blumenthal
 RS, Albert
 MA,
 et al. 2019 ACC/AHA guideline on the primary prevention of cardiovascular disease: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines.  Circulation . 2019;140(11):e596-e646. doi: 10.1161/CIR.0000000000000678 PubMed Google Scholar
Lloyd-Jones
 DM, Hong
 Y, Labarthe
 D,
 et al; American Heart Association Strategic Planning Task Force and Statistics Committee. Defining and setting national goals for cardiovascular health promotion and disease reduction: the American Heart Association’s Strategic Impact Goal through 2020 and beyond.  Circulation . 2010;121(4):586-613. doi: 10.1161/CIRCULATIONAHA.109.192703 PubMed Google Scholar Crossref
Mozaffarian
 D. Dietary and policy priorities for cardiovascular disease, diabetes, and obesity: a comprehensive review.  Circulation . 2016;133(2):187-225. doi: 10.1161/CIRCULATIONAHA.115.018585 PubMed Google Scholar Crossref
Khera
 AV, Emdin
 CA, Drake
 I,
 et al. Genetic risk, adherence to a healthy lifestyle, and coronary disease.  N Engl J Med . 2016;375(24):2349-2358. doi: 10.1056/NEJMoa1605086 PubMed Google Scholar Crossref
Marteau
 TM, French
 DP, Griffin
 SJ,
 et al. Effects of communicating DNA-based disease risk estimates on risk-reducing behaviours.  Cochrane Database Syst Rev . 2010;(10):CD007275. doi: 10.1002/14651858.CD007275.pub2 PubMed Google Scholar
Bycroft
 C, Freeman
 C, Petkova
 D,
 et al. The UK Biobank resource with deep phenotyping and genomic data.  Nature . 2018;562(7726):203-209. doi: 10.1038/s41586-018-0579-z PubMed Google Scholar Crossref
von Elm
 E, Altman
 DG, Egger
 M, Pocock
 SJ, Gøtzsche
 PC, Vandenbroucke
 JP; STROBE Initiative. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies.  Lancet . 2007;370(9596):1453-1457. doi: 10.1016/S0140-6736(07)61602-X PubMed Google Scholar Crossref
Fahed
 AC, Wang
 M, Homburger
 JR,
 et al. Polygenic background modifies penetrance of monogenic variants for tier 1 genomic conditions.  Nat Commun . 2020;11(1):3635. doi: 10.1038/s41467-020-17374-3 PubMed Google Scholar Crossref
UK Biobank. Definitions of acute myocardial infarction and main myocardial infarction pathological types: UK Biobank phase 1 outcomes adjudication. Published August 2017. Accessed June 1, 2020. https://biobank.ndph.ox.ac.uk/showcase/showcase/docs/alg_outcome_mi.pdf
Richards
 S, Aziz
 N, Bale
 S,
 et al; ACMG Laboratory Quality Assurance Committee. Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology.  Genet Med . 2015;17(5):405-424. doi: 10.1038/gim.2015.30 PubMed Google Scholar Crossref
Ye
 Y, Chen
 X, Han
 J, Jiang
 W, Natarajan
 P, Zhao
 H. Interactions between enhanced polygenic risk scores and lifestyle for cardiovascular disease, diabetes, and lipid levels.  Circ Genom Precis Med . 2021;14(1):e003128. doi: 10.1161/CIRCGEN.120.003128 PubMed Google Scholar
Said
 MA, Verweij
 N, van der Harst
 P. Associations of combined genetic and lifestyle risks with incident cardiovascular disease and diabetes in the UK Biobank Study.  JAMA Cardiol . 2018;3(8):693-702. doi: 10.1001/jamacardio.2018.1717 Article PubMed Google Scholar Crossref
Piercy
 KL, Troiano
 RP, Ballard
 RM,
 et al. The physical activity guidelines for Americans.  JAMA . 2018;320(19):2020-2028. doi: 10.1001/jama.2018.14854 Article PubMed Google Scholar Crossref
Cassidy
 S, Chau
 JY, Catt
 M, Bauman
 A, Trenell
 MI. Cross-sectional study of diet, physical activity, television viewing and sleep duration in 233,110 adults from the UK Biobank; the behavioural phenotype of cardiovascular disease and type 2 diabetes.  BMJ Open . 2016;6(3):e010038. doi: 10.1136/bmjopen-2015-010038 PubMed Google Scholar
Craig
 CL, Marshall
 AL, Sjöström
 M,
 et al. International physical activity questionnaire: 12-country reliability and validity.  Med Sci Sports Exerc . 2003;35(8):1381-1395. doi: 10.1249/01.MSS.0000078924.61453.FB PubMed Google Scholar Crossref
National Heart, Lung, and Blood Institute. The practical guide: identification, evaluation, and treatment of overweight and obesity in Adults. Published October 2000. Accessed April 28, 2021. https://www.nhlbi.nih.gov/files/docs/guidelines/prctgd_c.pdf
Price
 AL, Patterson
 NJ, Plenge
 RM, Weinblatt
 ME, Shadick
 NA, Reich
 D. Principal components analysis corrects for stratification in genome-wide association studies.  Nat Genet . 2006;38(8):904-909. doi: 10.1038/ng1847 PubMed Google Scholar Crossref
Foster
 HME, Celis-Morales
 CA, Nicholl
 BI,
 et al. The effect of socioeconomic deprivation on the association between an extended measurement of unhealthy lifestyle factors and health outcomes: a prospective analysis of the UK Biobank cohort.  Lancet Public Health . 2018;3(12):e576-e585. doi: 10.1016/S2468-2667(18)30200-7 PubMed Google Scholar Crossref
Mathur
 MB, VanderWeele
 TJ. R function for additive interaction measures.  Epidemiology . 2018;29(1):e5-e6. doi: 10.1097/EDE.0000000000000752 PubMed Google Scholar Crossref
Santos
 RD, Gidding
 SS, Hegele
 RA,
 et al; International Atherosclerosis Society Severe Familial Hypercholesterolemia Panel. Defining severe familial hypercholesterolaemia and the implications for clinical management: a consensus statement from the International Atherosclerosis Society Severe Familial Hypercholesterolemia Panel.  Lancet Diabetes Endocrinol . 2016;4(10):850-861. doi: 10.1016/S2213-8587(16)30041-9 PubMed Google Scholar Crossref
Gidding
 SS, Champagne
 MA, de Ferranti
 SD,
 et al; American Heart Association Atherosclerosis, Hypertension, and Obesity in Young Committee of Council on Cardiovascular Disease in Young, Council on Cardiovascular and Stroke Nursing, Council on Functional Genomics and Translational Biology, and Council on Lifestyle and Cardiometabolic Health. The agenda for familial hypercholesterolemia: a scientific statement from the American Heart Association.  Circulation . 2015;132(22):2167-2192. doi: 10.1161/CIR.0000000000000297 PubMed Google Scholar Crossref
Watts
 GF, Gidding
 S, Wierzbicki
 AS,
 et al. Integrated guidance on the care of familial hypercholesterolaemia from the International FH Foundation.  Int J Cardiol . 2014;171(3):309-325. doi: 10.1016/j.ijcard.2013.11.025 PubMed Google Scholar Crossref
Jones
 LK, Kulchak Rahm
 A, Manickam
 K,
 et al. Healthcare utilization and patients’ perspectives after receiving a positive genetic test for familial hypercholesterolemia.  Circ Genom Precis Med . 2018;11(8):e002146. doi: 10.1161/CIRCGEN.118.002146 PubMed Google Scholar
Denny
 JC, Rutter
 JL, Goldstein
 DB,
 et al; All of Us Research Program Investigators. The “All of Us” Research Program.  N Engl J Med . 2019;381(7):668-676. doi: 10.1056/NEJMsr1809937 PubMed Google Scholar
Schwartz
 MLB, McCormick
 CZ, Lazzeri
 AL,
 et al. A model for genome-first care: returning secondary genomic findings to participants and their healthcare providers in a large research cohort.  Am J Hum Genet . 2018;103(3):328-337. doi: 10.1016/j.ajhg.2018.07.009 PubMed Google Scholar Crossref
Karlson
 EW, Boutin
 NT, Hoffnagle
 AG, Allen
 NL. Building the Partners HealthCare Biobank at Partners personalized medicine: informed consent, return of research results, recruitment lessons and operational considerations.  J Pers Med . 2016;6(1):E2. doi: 10.3390/jpm6010002 PubMed Google Scholar
Parikh
 VN. Promise and peril of population genomics for the development of genome-first approaches in mendelian cardiovascular disease.  Circ Genom Precis Med . 2021;14(1):e002964. doi: 10.1161/CIRCGEN.120.002964 PubMed Google Scholar
Pérez de Isla
 L, Alonso
 R, Mata
 N,
 et al. Predicting cardiovascular events in familial hypercholesterolemia: the SAFEHEART registry (Spanish Familial Hypercholesterolemia Cohort Study).  Circulation . 2017;135(22):2133-2144. doi: 10.1161/CIRCULATIONAHA.116.024541 PubMed Google Scholar Crossref
Neil
 HA, Seagroatt
 V, Betteridge
 DJ,
 et al. Established and emerging coronary risk factors in patients with heterozygous familial hypercholesterolaemia.  Heart . 2004;90(12):1431-1437. doi: 10.1136/hrt.2003.022764 PubMed Google Scholar Crossref
Jansen
 ACM, van Aalst-Cohen
 ES, Tanck
 MW,
 et al. The contribution of classical risk factors to cardiovascular disease in familial hypercholesterolaemia: data in 2400 patients.  J Intern Med . 2004;256(6):482-490. doi: 10.1111/j.1365-2796.2004.01405.x PubMed Google Scholar Crossref
Besseling
 J, Kindt
 I, Hof
 M, Kastelein
 JJP, Hutten
 BA, Hovingh
 GK. Severe heterozygous familial hypercholesterolemia and risk for cardiovascular disease: a study of a cohort of 14,000 mutation carriers.  Atherosclerosis . 2014;233(1):219-223. doi: 10.1016/j.atherosclerosis.2013.12.020 PubMed Google Scholar Crossref
Tada
 H, Kawashiri
 MA, Nohara
 A, Inazu
 A, Mabuchi
 H, Yamagishi
 M. Impact of clinical signs and genetic diagnosis of familial hypercholesterolaemia on the prevalence of coronary artery disease in patients with severe hypercholesterolaemia.  Eur Heart J . 2017;38(20):1573-1579. doi: 10.1093/eurheartj/ehx004 PubMed Google Scholar Crossref
Pitsavos
 CH, Chrysohoou
 C, Panagiotakos
 DB,
 et al. Exercise capacity and heart rate recovery as predictors of coronary heart disease events, in patients with heterozygous familial hypercholesterolemia.  Atherosclerosis . 2004;173(2):347-352. doi: 10.1016/j.atherosclerosis.2003.12.027 PubMed Google Scholar Crossref
McGowan
 MP, Hosseini Dehkordi
 SH, Moriarty
 PM, Duell
 PB. Diagnosis and treatment of heterozygous familial hypercholesterolemia.  J Am Heart Assoc . 2019;8(24):e013225. doi: 10.1161/JAHA.119.013225 PubMed Google Scholar
Malhotra
 A, Shafiq
 N, Arora
 A, Singh
 M, Kumar
 R, Malhotra
 S. Dietary interventions (plant sterols, stanols, omega-3 fatty acids, soy protein and dietary fibers) for familial hypercholesterolaemia.  Cochrane Database Syst Rev . 2014;(6):CD001918. doi: 10.1002/14651858.CD001918.pub3 PubMed Google Scholar
Broekhuizen
 K, van Poppel
 MNM, Koppes
 LL, Kindt
 I, Brug
 J, van Mechelen
 W. No significant improvement of cardiovascular disease risk indicators by a lifestyle intervention in people with familial hypercholesterolemia compared to usual care: results of a randomised controlled trial.  BMC Res Notes . 2012;5:181. doi: 10.1186/1756-0500-5-181 PubMed Google Scholar Crossref
Broekhuizen
 K, van Poppel
 MNM, Koppes
 LL, Kindt
 I, Brug
 J, van Mechelen
 W. Can multiple lifestyle behaviours be improved in people with familial hypercholesterolemia? results of a parallel randomised controlled trial.  PLoS One . 2012;7(12):e50032. doi: 10.1371/journal.pone.0050032 PubMed Google Scholar
Fry
 A, Littlejohns
 TJ, Sudlow
 C,
 et al. Comparison of sociodemographic and health-related characteristics of UK Biobank participants with those of the general population.  Am J Epidemiol . 2017;186(9):1026-1034. doi: 10.1093/aje/kwx246 PubMed Google Scholar Crossref


Academic Medicine
Acid Base, Electrolytes, Fluids
Allergy and Clinical Immunology
Anesthesiology
Anticoagulation
Art and Images in Psychiatry
Bleeding and Transfusion
Cardiology
Caring for the Critically Ill Patient
Challenges in Clinical Electrocardiography
Clinical Challenge
Clinical Decision Support
Clinical Implications of Basic Neuroscience
Clinical Phar
Девушка со смуглой кожей не стесняется раздвигать ножки и показать красивую щелку перед камерой
Голые девушки очень любят выкладывать в сеть свои сексуальные фото
Приватный стриптиз пьяной женщины из Мьянмы

Report Page