Галерея 2758745

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Genes Dev

v.23(19); 2009 Oct 1

PMC2758745

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Genes Dev. 2009 Oct 1; 23(19): 2333–2344.
Global Health Institute, Ecole Polytechnique Federale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland
1 Corresponding authors.E-MAIL hc.lfpe@ertiamel.onurb ; FAX 41-21-693-17-90.
2 E-MAIL hc.lfpe@nohcub.salocin ; FAX 41-21-693-17-90.
Received 2009 Jun 2; Accepted 2009 Aug 25.
Copyright © 2009 by Cold Spring Harbor Laboratory Press
Keywords: Intestinal stem cell, proliferation, gut microbiota, JAK–STAT, JNK, pathogenic bacteria
Agaisse H, Petersen UM, Boutros M, Mathey-Prevot B, Perrimon N. Signaling role of hemocytes in Drosophila JAK/STAT-dependent response to septic injury. Dev Cell. 2003; 5 :441–450. [ PubMed ] [ Google Scholar ] Amcheslavsky A, Jiang J, Ip YT. Tissue damage-induced intestinal stem cell division in Drosophila . Cell Stem Cell. 2009; 4 :49–61. [ PMC free article ] [ PubMed ] [ Google Scholar ] Bach EA, Ekas LA, Ayala-Camargo A, Flaherty MS, Lee H, Perrimon N, Baeg GH. GFP reporters detect the activation of the Drosophila JAK/STAT pathway in vivo . Gene Expr Patterns. 2007; 7 :323–331. [ PubMed ] [ Google Scholar ] Basset A, Khush RS, Braun A, Gardan L, Boccard F, Hoffmann JA, Lemaitre B. The phytopathogenic bacteria Erwinia carotovora infects Drosophila and activates an immune response. Proc Natl Acad Sci. 2000; 97 :3376–3381. [ PMC free article ] [ PubMed ] [ Google Scholar ] Bates KL, Higley M, Letsou A. Raw mediates antagonism of AP-1 activity in Drosophila . Genetics. 2008; 178 :1989–2002. [ PMC free article ] [ PubMed ] [ Google Scholar ] Biteau B, Hochmuth CE, Jasper H. JNK Activity in somatic stem cells causes loss of tissue homeostasis in the aging Drosophila gut. Cell Stem Cell. 2008; 3 :442–455. [ PMC free article ] [ PubMed ] [ Google Scholar ] Brown S, Hu N, Hombria JC. Identification of the first invertebrate interleukin JAK/STAT receptor, the Drosophila gene domeless . Curr Biol. 2001; 11 :1700–1705. [ PubMed ] [ Google Scholar ] Buchon N, Broderick NA, Poidevin M, Pradervand S, Lemaitre B. Drosophila intestinal response to bacterial infection: Activation of host defense and stem cell proliferation. Cell Host Microbe. 2009; 5 :200–211. [ PubMed ] [ Google Scholar ] Chatterjee M, Ip YT. Pathogenic stimulation of intestinal stem cell response in Drosophila . J Cell Physiol. 2009; 220 :664–671. [ PMC free article ] [ PubMed ] [ Google Scholar ] Choi N, Kim J, Yang D, Kim Y, Yoo M. Age-related changes in Drosophila midgut are associated with PVF2, a PDGF/VEGF-like growth factor. Aging Cell. 2008; 7 :318–334. [ PMC free article ] [ PubMed ] [ Google Scholar ] Choi YJ, Hwang MS, Park JS, Bae SK, Kim YS, Yoo MA. Age-related upregulation of Drosophila caudal gene via NF-κB in the adult posterior midgut. Biochim Biophys Acta. 2008; 1780 :1093–1100. [ PubMed ] [ Google Scholar ] Cronin SJ, Nehme NT, Limmer S, Liegeois S, Pospisilik JA, Schramek D, Leibbrandt A, Simoes RD, Gruber S, Puc U, et al. Genome-wide RNAi screen identifies genes involved in intestinal pathogenic bacterial infection. Science. 2009; 325 :340–343. [ PMC free article ] [ PubMed ] [ Google Scholar ] Gregory L, Came PJ, Brown S. Stem cell regulation by JAK/STAT signaling in Drosophila . Semin Cell Dev Biol. 2008; 19 :407–413. [ PubMed ] [ Google Scholar ] Ha E, Oh C, Bae YS, Lee WJ. A direct role for dual oxidase in Drosophila gut immunity. Science. 2005a; 310 :847–850. [ PubMed ] [ Google Scholar ] Ha E, Oh C, Ryu J, Bae YS, Kang SW, Jang IH, Brey P, Lee WJ. An antioxidant system required for host protection against gut infection in Drosophila . Dev Cell. 2005b; 8 :125–132. [ PubMed ] [ Google Scholar ] Ha EM, Lee K, Park SH, Kim SH, Nam HJ, Lee HY, Kang D, Lee WJ. Regulation of DUOX by the Gαq-phospholipase Cβ-Ca 2+ pathway in Drosophila gut immunity. Dev Cell. 2009; 16 :386–397. [ PubMed ] [ Google Scholar ] Harrison DA, Perrimon N. Simple and efficient generation of marked clones in Drosophila . Curr Biol. 1993; 3 :424–433. [ PubMed ] [ Google Scholar ] Hooper LV. Bacterial contributions to mammalian gut development. Trends Microbiol. 2004; 12 :129–134. [ PubMed ] [ Google Scholar ] Hooper LV. Do symbiotic bacteria subvert host immunity? Nat Rev Microbiol. 2009; 7 :367–374. [ PubMed ] [ Google Scholar ] Iwai H, Kim M, Yoshikawa Y, Ashida H, Ogawa M, Fujita Y, Muller D, Kirikae T, Jackson PK, Kotani S, et al. A bacterial effector targets Mad2L2, an APC inhibitor, to modulate host cell cycling. Cell. 2007; 130 :611–623. [ PubMed ] [ Google Scholar ] Jiang H, Patel PH, Kohlmaier A, Grenley MO, McEwen DG, Edgar BA. Cytokine/Jak/Stat signaling mediates regeneration and homeostasis in the Drosophila midgut. Cell. 2009; 137 :1343–1355. [ PMC free article ] [ PubMed ] [ Google Scholar ] Krzemień J, Dubois L, Makki R, Meister M, Vincent A, Crozatier M. Control of blood cell homeostasis in Drosophila larvae by the posterior signaling centre. Nature. 2007; 446 :325–328. [ PubMed ] [ Google Scholar ] Lee T, Luo L. Mosaic analysis with a repressible cell marker (MARCM) for Drosophila neural development. Trends Neurosci. 2001; 24 :251–254. [ PubMed ] [ Google Scholar ] Liehl P, Blight M, Vodovar N, Boccard F, Lemaitre B. Prevalence of local immune response against oral infection in a Drosophila / Pseudomonas infection model. PLoS Pathog. 2006; 2 :e56. doi: 10.1371/journal. ppat.0020056. [ PMC free article ] [ PubMed ] [ CrossRef ] [ Google Scholar ] Macdonald TT, Monteleone G. Immunity, inflammation, and allergy in the gut. Science. 2005; 307 :1920–1925. [ PubMed ] [ Google Scholar ] Martín-Blanco E, Gampel A, Ring J, Virdee K, Kirov N, Tolkovsky AM, Martinez-Arias A. puckered encodes a phosphatase that mediates a feedback loop regulating JNK activity during dorsal closure in Drosophila . Genes & Dev. 1998; 12 :557–570. [ PMC free article ] [ PubMed ] [ Google Scholar ] Micchelli CA, Perrimon N. Evidence that stem cells reside in the adult Drosophila midgut epithelium. Nature. 2006; 439 :475–479. [ PubMed ] [ Google Scholar ] Mimuro H, Suzuki T, Nagai S, Rieder G, Suzuki M, Nagai T, Fujita Y, Nagamatsu K, Ishijima N, Koyasu S, et al. Helicobacter pylori dampens gut epithelial self-renewal by inhibiting apoptosis, a bacterial strategy to enhance colonization of the stomach. Cell Host Microbe. 2007; 2 :250–263. [ PubMed ] [ Google Scholar ] Ohlstein B, Spradling AC. The adult Drosophila posterior midgut is maintained by pluripotent stem cells. Nature. 2006; 439 :470–474. [ PubMed ] [ Google Scholar ] Park JS, Kim YS, Yoo MA. The role of p38b MAPK in age-related modulation of intestinal stem cell proliferation and differentiation in Drosophila . Aging. 2009; 1 :637–651. [ PMC free article ] [ PubMed ] [ Google Scholar ] Pedron T, Sansonetti PJ. Commensals, bacterial pathogens and intestinal inflammation: An intriguing ménage à trois. Cell Host Microbe. 2008; 3 :344–347. [ PubMed ] [ Google Scholar ] Radtke F, Clevers H. Self-renewal and cancer of the gut: Two sides of a coin. Science. 2005; 307 :1904–1909. [ PubMed ] [ Google Scholar ] Ren C, Webster P, Finkel SE, Tower J. Increased internal and external bacterial load during Drosophila aging without life-span trade-off. Cell Metab. 2007; 6 :144–152. [ PubMed ] [ Google Scholar ] Romeo Y, Lemaitre B. Drosophila immunity: Methods for monitoring the activity of toll and imd signaling pathways. Methods Mol Biol. 2008; 415 :379–394. [ PubMed ] [ Google Scholar ] Ryu J, Ha E, Oh C, Seol J, Brey P, Jin I, Lee D, Kim J, Lee D, Lee WJ. An essential complementary role of NF-κB pathway to microbicidal oxidants in Drosophila gut immunity. EMBO J. 2006; 25 :3693–3701. [ PMC free article ] [ PubMed ] [ Google Scholar ] Sansonetti PJ. War and peace at mucosal surfaces. Nat Rev Immunol. 2004; 4 :953–964. [ PubMed ] [ Google Scholar ] Vodovar N, Vinals M, Liehl P, Basset A, Degrouard J, Spellman P, Boccard F, Lemaitre B. Drosophila host defense after oral infection by an entomopathogenic Pseudomonas species. Proc Natl Acad Sci. 2005; 102 :11414–11419. [ PMC free article ] [ PubMed ] [ Google Scholar ] Wang MC, Bohmann D, Jasper H. JNK signaling confers tolerance to oxidative stress and extends lifespan in Drosophila . Dev Cell. 2003; 5 :811–816. [ PubMed ] [ Google Scholar ] Zaidman-Remy A, Herve M, Poidevin M, Pilifloury S, Kim MO, Blanot D, Oh BH, Ueda R, Mengin-Lecreulx D, Lemaitre B. The Drosophila amidase PGRP-LB modulates the immune response to bacterial infection. Immunity. 2006; 24 :463–473. [ PubMed ] [ Google Scholar ]
Articles from Genes & Development are provided here courtesy of Cold Spring Harbor Laboratory Press
Sansonetti PJ. War and peace at mucosal surfaces. Nat Rev Immunol. 2004; 4 :953–964. [ PubMed ] [ Google Scholar ] [ Ref list ]
Pedron T, Sansonetti PJ. Commensals, bacterial pathogens and intestinal inflammation: An intriguing ménage à trois. Cell Host Microbe. 2008; 3 :344–347. [ PubMed ] [ Google Scholar ] [ Ref list ]
Micchelli CA, Perrimon N. Evidence that stem cells reside in the adult Drosophila midgut epithelium. Nature. 2006; 439 :475–479. [ PubMed ] [ Google Scholar ] [ Ref list ]
Ohlstein B, Spradling AC. The adult Drosophila posterior midgut is maintained by pluripotent stem cells. Nature. 2006; 439 :470–474. [ PubMed ] [ Google Scholar ] [ Ref list ]
Buchon N, Broderick NA, Poidevin M, Pradervand S, Lemaitre B. Drosophila intestinal response to bacterial infection: Activation of host defense and stem cell proliferation. Cell Host Microbe. 2009; 5 :200–211. [ PubMed ] [ Google Scholar ] [ Ref list ]
Zaidman-Remy A, Herve M, Poidevin M, Pilifloury S, Kim MO, Blanot D, Oh BH, Ueda R, Mengin-Lecreulx D, Lemaitre B. The Drosophila amidase PGRP-LB modulates the immune response to bacterial infection. Immunity. 2006; 24 :463–473. [ PubMed ] [ Google Scholar ] [ Ref list ]
Ha E, Oh C, Bae YS, Lee WJ. A direct role for dual oxidase in Drosophila gut immunity. Science. 2005a; 310 :847–850. [ PubMed ] [ Google Scholar ] [ Ref list ]
Biteau B, Hochmuth CE, Jasper H. JNK Activity in somatic stem cells causes loss of tissue homeostasis in the aging Drosophila gut. Cell Stem Cell. 2008; 3 :442–455. [ PMC free article ] [ PubMed ] [ Google Scholar ] [ Ref list ]
Chatterjee M, Ip YT. Pathogenic stimulation of intestinal stem cell response in Drosophila . J Cell Physiol. 2009; 220 :664–671. [ PMC free article ] [ PubMed ] [ Google Scholar ] [ Ref list ]
Ha EM, Lee K, Park SH, Kim SH, Nam HJ, Lee HY, Kang D, Lee WJ. Regulation of DUOX by the Gαq-phospholipase Cβ-Ca 2+ pathway in Drosophila gut immunity. Dev Cell. 2009; 16 :386–397. [ PubMed ] [ Google Scholar ] [ Ref list ]
Ha E, Oh C, Ryu J, Bae YS, Kang SW, Jang IH, Brey P, Lee WJ. An antioxidant system required for host protection against gut infection in Drosophila . Dev Cell. 2005b; 8 :125–132. [ PubMed ] [ Google Scholar ] [ Ref list ]
Amcheslavsky A, Jiang J, Ip YT. Tissue damage-induced intestinal stem cell division in Drosophila . Cell Stem Cell. 2009; 4 :49–61. [ PMC free article ] [ PubMed ] [ Google Scholar ] [ Ref list ]
Gregory L, Came PJ, Brown S. Stem cell regulation by JAK/STAT signaling in Drosophila . Semin Cell Dev Biol. 2008; 19 :407–413. [ PubMed ] [ Google Scholar ] [ Ref list ]
Bach EA, Ekas LA, Ayala-Camargo A, Flaherty MS, Lee H, Perrimon N, Baeg GH. GFP reporters detect the activation of the Drosophila JAK/STAT pathway in vivo . Gene Expr Patterns. 2007; 7 :323–331. [ PubMed ] [ Google Scholar ] [ Ref list ]
Brown S, Hu N, Hombria JC. Identification of the first invertebrate interleukin JAK/STAT receptor, the Drosophila gene domeless . Curr Biol. 2001; 11 :1700–1705. [ PubMed ] [ Google Scholar ] [ Ref list ]
Lee T, Luo L. Mosaic analysis with a repressible cell marker (MARCM) for Drosophila neural development. Trends Neurosci. 2001; 24 :251–254. [ PubMed ] [ Google Scholar ] [ Ref list ]
Agaisse H, Petersen UM, Boutros M, Mathey-Prevot B, Perrimon N. Signaling role of hemocytes in Drosophila JAK/STAT-dependent response to septic injury. Dev Cell. 2003; 5 :441–450. [ PubMed ] [ Google Scholar ] [ Ref list ]
Wang MC, Bohmann D, Jasper H. JNK signaling confers tolerance to oxidative stress and extends lifespan in Drosophila . Dev Cell. 2003; 5 :811–816. [ PubMed ] [ Google Scholar ] [ Ref list ]
Martín-Blanco E, Gampel A, Ring J, Virdee K, Kirov N, Tolkovsky AM, Martinez-Arias A. puckered encodes a phosphatase that mediates a feedback loop regulating JNK activity during dorsal closure in Drosophila . Genes & Dev. 1998; 12 :557–570. [ PMC free article ] [ PubMed ] [ Google Scholar ] [ Ref list ]
Basset A, Khush RS, Braun A, Gardan L, Boccard F, Hoffmann JA, Lemaitre B. The phytopathogenic bacteria Erwinia carotovora infects Drosophila and activates an immune response. Proc Natl Acad Sci. 2000; 97 :3376–3381. [ PMC free article ] [ PubMed ] [ Google Scholar ] [ Ref list ]
Hooper LV. Bacterial contributions to mammalian gut development. Trends Microbiol. 2004; 12 :129–134. [ PubMed ] [ Google Scholar ] [ Ref list ]
Choi N, Kim J, Yang D, Kim Y, Yoo M. Age-related changes in Drosophila midgut are associated with PVF2, a PDGF/VEGF-like growth factor. Aging Cell. 2008; 7 :318–334. [ PMC free article ] [ PubMed ] [ Google Scholar ] [ Ref list ]
Park JS, Kim YS, Yoo MA. The role of p38b MAPK in age-related modulation of intestinal stem cell proliferation and differentiation in Drosophila . Aging. 2009; 1 :637–651. [ PMC free article ] [ PubMed ] [ Google Scholar ] [ Ref list ]
Ren C, Webster P, Finkel SE, Tower J. Increased internal and external bacterial load during Drosophila aging without life-span trade-off. Cell Metab. 2007; 6 :144–152. [ PubMed ] [ Google Scholar ] [ Ref list ]
Vodovar N, Vinals M, Liehl P, Basset A, Degrouard J, Spellman P, Boccard F, Lemaitre B. Drosophila host defense after oral infection by an entomopathogenic Pseudomonas species. Proc Natl Acad Sci. 2005; 102 :11414–11419. [ PMC free article ] [ PubMed ] [ Google Scholar ] [ Ref list ]
Liehl P, Blight M, Vodovar N, Boccard F, Lemaitre B. Prevalence of local immune response against oral infection in a Drosophila / Pseudomonas infection model. PLoS Pathog. 2006; 2 :e56. doi: 10.1371/journal. ppat.0020056. [ PMC free article ] [ PubMed ] [ CrossRef ] [ Google Scholar ] [ Ref list ]
Jiang H, Patel PH, Kohlmaier A, Grenley MO, McEwen DG, Edgar BA. Cytokine/Jak/Stat signaling mediates regeneration and homeostasis in the Drosophila midgut. Cell. 2009; 137 :1343–1355. [ PMC free article ] [ PubMed ] [ Google Scholar ] [ Ref list ]
Bates KL, Higley M, Letsou A. Raw mediates antagonism of AP-1 activity in Drosophila . Genetics. 2008; 178 :1989–2002. [ PMC free article ] [ PubMed ] [ Google Scholar ] [ Ref list ]
Ryu J, Ha E, Oh C, Seol J, Brey P, Jin I, Lee D, Kim J, Lee D, Lee WJ. An essential complementary role of NF-κB pathway to microbicidal oxidants in Drosophila gut immunity. EMBO J. 2006; 25 :3693–3701. [ PMC free article ] [ PubMed ] [ Google Scholar ] [ Ref list ]
Iwai H, Kim M, Yoshikawa Y, Ashida H, Ogawa M, Fujita Y, Muller D, Kirikae T, Jackson PK, Kotani S, et al. A bacterial effector targets Mad2L2, an APC inhibitor, to modulate host cell cycling. Cell. 2007; 130 :611–623. [ PubMed ] [ Google Scholar ] [ Ref list ]
Mimuro H, Suzuki T, Nagai S, Rieder G, Suzuki M, Nagai T, Fujita Y, Nagamatsu K, Ishijima N, Koyasu S, et al. Helicobacter pylori dampens gut epithelial self-renewal by inhibiting apoptosis, a bacterial strategy to enhance colonization of the stomach. Cell Host Microbe. 2007; 2 :250–263. [ PubMed ] [ Google Scholar ] [ Ref list ]
Cronin SJ, Nehme NT, Limmer S, Liegeois S, Pospisilik JA, Schramek D, Leibbrandt A, Simoes RD, Gruber S, Puc U, et al. Genome-wide RNAi screen identifies genes involved in intestinal pathogenic bacterial infection. Science. 2009; 325 :340–343. [ PMC free article ] [ PubMed ] [ Google Scholar ] [ Ref list ]
Hooper LV. Do symbiotic bacteria subvert host immunity? Nat Rev Microbiol. 2009; 7 :367–374. [ PubMed ] [ Google Scholar ] [ Ref list ]
Macdonald TT, Monteleone G. Immunity, inflammation, and allergy in the gut. Science. 2005; 307 :1920–1925. [ PubMed ] [ Google Scholar ] [ Ref list ]
Radtke F, Clevers H. Self-renewal and cancer of the gut: Two sides of a coin. Science. 2005; 307 :1904–1909. [ PubMed ] [ Google Scholar ] [ Ref list ]
Harrison DA, Perrimon N. Simple and efficient generation of marked clones in Drosophila . Curr Biol. 1993; 3 :424–433. [ PubMed ] [ Google Scholar ] [ Ref list ]
Romeo Y, Lemaitre B. Drosophila immunity: Methods for monitoring the activity of toll and imd signaling pathways. Methods Mol Biol. 2008; 415 :379–394. [ PubMed ] [ Google Scholar ] [ Ref list ]

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Global Health Institute, Ecole Polytechnique Federale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland
Global Health Institute, Ecole Polytechnique Federale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland
Global Health Institute, Ecole Polytechnique Federale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland
Global Health Institute, Ecole Polytechnique Federale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland
Gut homeostasis is controlled by both immune and developmental mechanisms, and its disruption can lead to inflammatory disorders or cancerous lesions of the intestine. While the impact of b
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Галерея 2758745

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