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Leave No Trace Trainer Course (Camp Teetonkah)
Map of Event $ View Pricing Coords: 42.208412, -84.2394752 3710 Burkhart Road Jackson, Michigan 49201 Registration Closes: 04-16-2023 11:59 PM
The Michigan Crossroads Council is sponsoring this special Trainer course for all individuals, youth and adult, wanting to be verified as Trainers of Leave No Trace. Youth, 14 and older will need this course to fulfill the requirements of their units new BSA Outdoor Ethics Position of Responsibility.
Units are encouraged to have both an adult and youth trainer to deliver a complete LNT program - multiple registrations from the same unit will receive a $10/person discount. Ask your Committee to support their unit by covering the cost of this unique course!
An updated BSA Annual Health Form A&B is required for all Participants
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Genome Biol
v.8(6); 2007
PMC2394752
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Published online 2007 Jun 6. doi: 10.1186/gb-2007-8-6-r104
1 The Hamner Institutes for Health Sciences, 6 Davis Drive, PO Box 12137, Research Triangle Park, NC 27709-2137, USA
2 Genomics Institute of the Novartis Research Foundation, 10675 John J. Hopkins Drive, San Diego, CA 92121, USA
3 Institute for Translational Medicine and Therapeutics, 810 Biomedical Research Building, University of Pennsylvania School of Medicine, 421 Curie Boulevard, Philadelphia, PA 19104-6160, USA
4 Almac Diagnostics, 801-1 Capitola Drive, Durham, NC 27713, USA
Thomas A Halsey: gro.renmaheht@yeslaht ; Longlong Yang: gro.renmaheht@gnayl ; John R Walker: gro.fng@reklawj ; John B Hogenesch: ude.nnepu.dem.liam@csenegoh ; Russell S Thomas: gro.renmaheht@samohtr
Received 2006 Jan 9; Revised 2007 Apr 3; Accepted 2007 Jun 6.
Copyright © 2007 Thomas et al.; licensee BioMed Central Ltd.
Additional data file 1 A complete list of positive NFκB modulators identified using the gain-of-function full-length gene screens.
GUID: 1930B040-3948-40B9-8D28-85C408C3E849
Additional data file 2 A complete list of negative NFκB modulators identified using the loss-of-function full-length gene screens.
GUID: 4E3AEBEC-9AF5-42F4-A775-6B1508601D4A
Additional data file 3 A table listing the reduction in NFκB activation by the positive modulators using the IKBKB, IKBKG, MAP3K7, and TRAF2 dominant-negative mutants.
GUID: 8B2B3641-FD7E-492C-9A31-6A746A848099
Additional data file 4 A table listing the reduction in NFκB activation by a constitutively active IKBKB mutant using the negative NFκB modulators.
GUID: 0014435B-EB24-47B4-8E43-E353E0CE9E85
Additional data file 5 A figure of the overlap and location of positive and negative modulators identified in the cell-based screens within the canonical TNF (A) and IL1 (B) signaling pathways. The signaling pathways were obtained from the Human Protein Reference Database and visualized using GenMAPP 2.1. The green shaded boxes represent positive modulators and red shaded boxes represent negative modulators. Green shaded boxes with red borders represent modulators that were identified as both positive and negative.
GUID: 0D70F9B7-9F51-4CED-B6ED-14A5703D2151
Additional data file 6 A figure showing the overlap and location of positive and negative modulators identified in the cell-based screens within the canonical B-cell receptor (A) and T-cell receptor (B) signaling pathways. The signaling pathways were obtained from the Human Protein Reference Database and visualized using GenMAPP 2.1. The green shaded boxes represent positive modulators and red shaded boxes represent negative modulators. Green shaded boxes with red borders represent modulators that were identified as both positive and negative.
GUID: 5F9DC9EE-6DE6-44CD-8FF4-44A6AD7B0E26
Additional data file 7 A figure showing a network map of the NFκB modulators. An adjacency matrix was constructed on the basis of the orientation flags from the dominant-negative and constitutively active screens (that is, upstream, downstream, or unclassified). The adjacency matrix containing the experimental data was merged with a separate adjacency matrix containing members of the currently accepted NFκB signaling network. Based on the combined adjacency matrix, a network map was constructed as a rooted tree with the NFκB complex serving as the obligate root node. The longest path was calculated from each terminal node to the root node. Peach nodes = positive modulators; green nodes = negative modulators; pink nodes = genes identified as both positive and negative modulators; orange nodes = members of the known NFκB signaling network; red nodes = dominant-negative mutants (plus TRAF2); blue nodes = positive modulators whose network location was adjusted based on the currently accepted NFκB network structure.
GUID: A4D70202-E68D-4860-9CB3-8315D46C8193
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