Foliber sekmesi, 28 adet.
hAYtEdmrPSiteye Git (Ürün Sayfası) »
doğurganlık çağındaki kadınlarda gebelik planlama aşamalarında (gebe kalmadan en az 1 ay önce) folik asit ve B12 vitamini eksikliğinin önlenmesi; Gebeliğin ilk üç ayında fetüste nöral tüp defektlerinin gelişmesini önlemek için. İlacın bileşenlerine aşırı duyarlılık İlaç, glikoz veya galaktoz emilimi, galaktozemi veya laktaz eksikliği olan hastalarda, ilaç tablet başına 23 mg laktoz içerdiğinden dikkatli kullanılmalıdır. 1 sekme. folik asit (vit. Bc) 400 mcg siyanokobalamin (vit. B12) 2 mcg Yardımcı maddeler: sodyum karboksinişasta tip A, magnezyum stearat, laktoz monohidrat, mikrokristalin selüloz, trisodyum sitrat, sitrik asit, maltodekstrin. Tabletler düz, yuvarlak ve sarıdır. Emilim Folik asit jejunumda hızla emilir, indirgenir ve portal dolaşımda bulunan 5-metiltetrahidrofolata metilasyona uğrar. Kan plazmasındaki Cmax 30-60 dakika sonra gözlenir. Ayrıca B12 vitamini, midenin parietal hücreleri tarafından salgılanan bir glikoprotein olan “iç Kale faktörü” ile midede etkileşime girdikten sonra emilebilir. Plazmadaki Cmaks, 8-12 saat sonra gözlenir. Folik asitte olduğu gibi, B12 vitamini önemli ölçüde enterohepatik resirkülasyona uğrar. B12 vitamini ve metaboliti 5-metiltetrahidrofolat büyük oranda plazma proteinlerine bağlanır, fazlası karaciğerde birikir. B12 vitamini plasentadan geçer. B12 vitamini ve folat anne sütüne geçmektedir. Atılım Her gün folik asit, 10-formiltetrahidrofolat ve 5-metiltetrahidrofolat formunda 4-5 mcg folat idrarla atılmaktadır. B12 vitamininin ortalama T1/2'si yaklaşık 6 gündür. Uygulanan dozun bir kısmı ilk 8 saat içinde idrarla atılır, ancak çoğu safrayla atılır. %25'i dışkıyla atılır. İlaç hamilelik sırasında endikasyonlara göre kullanılır. İlaç yemeklerden önce günde 1 tablet alınmalıdır. Olası: alerjik reaksiyonlar Foliber, metotreksat ile kombinasyon halinde kullanılmamalıdır, çünkü metotreksat, folik asit antagonisti olarak etki göstererek hidrofolat redüktaz enzimini inhibe eder. Foliber, hidantoin grubundan antiepileptik ilaçlarla birlikte kullanıldığında ikincisinin etkilerini azaltabilir. . Doz aşımı ile ilgili veriler sağlanmamıştır. Trafiği yönetme becerisi üzerindeki etkisi
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