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It was , and we thought of the drug as Ecstasy , or Molly, and associated it with raves. But something about his demeanor made us think that he was upset. Was he sure that everything was fine? Did he want to tell us what had happened? John closed the toilet lid, sat down, and began to talk. He was a serious musician who played in both an orchestra and a rock band; he said that, earlier that day, a friend of his had asked why he bothered with the band. As he told us about it, he started to tear up. Her comment, I sensed, had pricked a tender spot in his idea of himself. At the time, I thought of John as a friend but not necessarily a close confidant—but I was on empathy overdrive, and it felt intolerable to see him hurting. We got to work trying to help him sort things out, reminding him what a talented musician we knew him to be. Some key elements of therapy were involved: we listened, with focussed attention, while John told us what was bothering him, and we asked why the remark had hurt so much. When he confessed his anxieties, we tried to validate and reassure him. In my memory, John left the bathroom feeling better, and so did I; I remember that conversation as a turning point in our friendship. Strangely, a chemical seemed to facilitate this connection. In recent years, growing numbers of scientists have been asking whether MDMA could become a recognized, official part of psychotherapy. Rachel Yehuda, who runs a lab at Mount Sinai focussed on post-traumatic stress disorder, or P. Such a development would force us to change our idea of the drug. Many people still think of MDMA as a chemical that makes you feel good when you go out dancing all night long. But what if its greatest power is an ability to inspire empathetic conversations? The meaning of MDMA is changing. What kind of a drug is it going to be? MDMA takes its name from its chemical formula: 3,4-methylenedioxymethamphetamine. But, as others began to synthesize and share it, Shulgin feared that it would become known as a recreational drug and the D. It proved successful enough there that, one day, he visited Bob McMillen, who had been a major marijuana distributor in California. He told McMillen that he had been using a drug that was going to be a big deal, and he wanted to sell it on the West Coast. Clegg even had a name for the molecule: Therapy. After some cajoling, McMillen agreed to sample it. He put on an album by the New Age instrumentalist Deuter and sat on his couch, under a sheet. How much can I get? He chose the name of the Deuter album, and in four days he sold five thousand units of Ecstasy. MDMA was gaining a sort of split personality, as a potentially therapeutic chemical on the one hand and as pleasure in pill form on the other. In part for this reason, in , the D. In the decades that followed, a research and advocacy organization, the Multidisciplinary Association for Psychedelic Studies, or MAPS , tried to make psychedelics acceptable and accessible to the public. In a Phase 2 clinical trial started in , a hundred and seven people with a P. When the study concluded, fifty-six per cent of those given MDMA and therapy no longer met the diagnostic criteria for the disorder, more than twice as many as those in the placebo group. One downside of such studies is their small size; another is that they do not test MDMA without therapy, making it difficult to disentangle the impacts of the drug from the sessions. Now that Mithoefer and his colleagues have completed an additional Phase 3 trial, his team plans to submit an application for prescription use to the F. No one is suggesting that patients take MDMA every day, like Wellbutrin, or as needed to combat acute distress, like Xanax. Instead, MDMA is a drug that one might take in combination with therapy, during sessions—less a treatment than a treatment enhancer. The exact mechanisms through which MDMA works are not well understood. In one, researchers mistakenly administered methamphetamine to subjects, yet reported the results as coming from MDMA. He claimed in legal filings that the relationship was consensual; MAPS cut ties with both therapists. If the F. A substance that has long been associated with parties could be mainstreamed and medicalized; many more people might try a new category of mental-health care, which could come with new kinds of risks. There could come a day when MDMA is associated less with feeling good than with trying to get better. In the late nineteen-nineties, a psychiatrist named Charles Grob published a study showing that MDMA could be safely administered in a medical setting. His researchers administered the drug at a hospital to volunteers who, per the F. The only person who had a problem with the tests, he reported, was the head nurse. She was annoyed that her nurses were neglecting their duties, instead choosing to spend time with the study participants. One of the peculiarities of MDMA is that it turns its users into listeners. When someone takes MDMA in the presence of a therapist, they might feel more supported and secure in this bond, and more able to dredge up painful feelings or hard memories without being overwhelmed by fear or shame. When I took it, I felt my bond with John a little more powerfully. Therapy helps, in part, because human connection is good for us. It matters when someone listens to you, and when you listen. Recently, I reached out to John to ask him how he recalled our encounter in the dorm bathroom. When I asked about that day, he laughed and told me that he remembered our conversation as a soothing one. But he never suspected that we were on MDMA. In order to function properly, Democracy needs the loser. What happens to all the stuff we return? When the piano world got played. The Vogue model who became a war photographer. The age of Instagram face. Sign up for our daily newsletter to receive the best stories from The New Yorker. Save this story Save this story. New Yorker Favorites. At first, scientists just wanted to figure out the best way to kill these pests. Then they decided that studying rat society could reveal the future of our own. By Elizabeth Kolbert. Annals of Psychology. By Eren Orbey. Open Questions. By Joshua Rothman. Does Anyone Really Know You? Our yearning to be fully known is inevitable—and, perhaps, misleading. Book Currents. Don Luigi Ciotti leads an anti-Mafia organization, and for decades he has run a secret operation that liberates women from the criminal underworld. Is It Time to Torch the Constitution? By Louis Menand. Pop Music. By Amanda Petrusich. A Reporter at Large. Four daughters in the royal family were kept drugged and imprisoned for almost two decades. A physician who tried to free them speaks out for the first time. By Heidi Blake. The Lede. Treating political violence as a contagion could help safeguard the future of American democracy. By Michael Luo. The Relentlessness of Florida Hurricane Season. For residents still picking through the destruction caused by Hurricane Helene, the arrival of Milton was met with anxiety, horror, and, in some cases, weary acceptance. By Carolyn Kormann. By Michael Schulman.

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Leslie has taken pills to Nass festival that are stronger than he has ever used before. Ecstasy, or MDMA, is becoming more readily available to buy, particularly on the so-called 'dark web'. And this has seen the drug grow in popularity, and in strength. Leslie - not his real name - is 18, and has come with friends to Nass festival in Somerset - an event that celebrates music, skating and BMX riding. It has a zero-tolerance policy on drugs, but it is clear to see that this is being defied. The drug of choice appears to be MDMA. He says it is the first time he has ever been scared of what he is using. Festival organiser Ryan Matthews is clear that 'if people are caught with any illegal drugs on site, they are ejected'. But there are other worries too, of which Leslie is well aware. Many illegal drugs are diluted with other cutting agents - in some cases, horse tranquilliser or rat poison. Without a middleman, he says, the purity of the drug is maintained. The devastating effects of ecstasy, however, are well documented. There has been a fourfold increase in British female clubbers seeking emergency medical treatment in the past three years, according to the Global Drug Survey Michelle Shevlin's year-old daughter, Stephanie, died in June after taking a pill in a nightclub. Michelle Shevlin is finding it difficult to come to terms with her daughter's death. Ms Shevlin has a clear message for the dealer who supplied the drug that caused her daughter's death. The single pill that ultimately killed Stephanie was almost certainly weaker than just one of the three or four pills Leslie took at the festival. And this is why Trevor Shine, from Tictac Drug Identification, believes that taking illegal, unregulated drugs is a 'lottery' - with people's bodies affected in different ways. He measures the strength of Leslie's drugs, and finds they are worryingly pure. The ecstasy tablet he examines contains mg of MDMA, whereas 'traditionally, the average dose in an ecstasy tablet would have been mg'. Trevor Shine believes the strength of Leslie's pills is dangerous. Mr Shine warns users of the dangers of taking the same amount of pills when the strength is so much purer, as they would with a lower dose. Other class-A drugs - in particular cocaine and crack cocaine - have also seen a recent increase in strength, according to Tictac pharmaceutical analyst Anca Frinculescu. After the festival, we reconvene with Leslie to discuss the findings. He is unable to remember his evenings at the festival, but knows - on the night we met him - he had to take 'quite a few more' tablets to replicate 'the same effects of the first one'. He appears visibly moved when told of Ms Shevlin's loss of her daughter. Danger from ecstasy 'greater than ever'. Ecstasy and MDMA is 'getting stronger'. By James Longman. BMX contests are held as part of the festival. Find out more. It can cause serious health risks. More on this story.

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