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Clinical trials that are designed to help inform practice in the real world are called pragmatic trials. They are often described as a focus on the practical aspects of designing a study which include the recruitment and consent process, as well as adherence and the use of routinely available equipment.

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Another example of a practical trial is the Home Blood Pressure Management (HBPM) study, which employed various investigators and included participants from various geographical areas. This type of heterogeneity, which is essential for a pragmatic trial to be valid and lessen the chance of bias, is also necessary. However excessive heterogeneity could cause problems with the design of the trial.

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Pragmatic Play has earned a name for itself by providing top-quality games and an outstanding user experience. Its software is designed to work with mobile devices and is compatible with multiple languages. It has established itself as one of the most popular casino gaming platforms despite its relatively young age. The most recent releases include Wolves 5 reel video slot that has a healthy RTP and stunning graphics. Other notable games include Wolf Gold and Chilli Heat.

The purpose of pragmatic trials is to mimic real-life scenarios and gain maximum validity externally. Usually, they are commissioned by policymakers and practitioners to help inform their decisions. They can be used to determine the causal relationship between an intervention and its results. However, they should not be used to replace explanation studies.

The concept of pragmatism is controversial, and there are questions about whether pragmatic trials can replace tests for explanations or if they should serve as an addition to them. Schwartz and Lellouch1 proposed a distinction between explanatory studies, which prove a physiological hypothesis or clinical hypothesis, as well as pragmatic trials, that inform the decision-making process for policy and practice. They also proposed a framework called PRECIS for pragmatic trials.2 The tool was designed to define the elements of a practical study, including recruitment, design, delivery of the intervention and its follow-up.

The number of pragmatic trials is increasing. A recent Medline query that used the words naturalistic and pragmatic, restricted to randomised controlled trials (RCTs), returned 34 articles. These are shown in red on Figure 2. This indicates that the health sciences community has become more aware of the importance of pragmatic thinking. It is important to note that the majority were conducted in primary-care settings.