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It is a colorless oil that is soluble in organic solvents. This substance is used in the manufacture of methamphetamine and amphetamine , where it is commonly known as P2P. Due to the illicit uses in clandestine chemistry , it was declared a schedule II controlled substance in the United States in From Wikipedia, the free encyclopedia. Benzyl methyl ketone; Methyl benzyl ketone; Phenylpropanone. Metabolic pathways of amphetamine in humans \\\\\\\\\\\\\[sources 1\\\\\\\\\\\\\]. Department of Justice , Drug Enforcement Administration. United States Food and Drug Administration. Retrieved 30 December The simplest unsubstituted phenylisopropylamine, 1-phenylaminopropane, or amphetamine, serves as a common structural template for hallucinogens and psychostimulants. Amphetamine produces central stimulant, anorectic, and sympathomimetic actions, and it is the prototype member of this class The phase 1 metabolism of amphetamine analogs is catalyzed by two systems: Amphetamine can also undergo aromatic hydroxylation to p -hydroxyamphetamine. Stereochemical course of the reaction' PDF. Retrieved 6 November Hydroxyamphetamine was administered orally to five human subjects The lack of effect of administration of neomycin to one patient indicates that the hydroxylation occurs in body tissues. Unfortunately, at the present time one cannot be completely certain that the hydroxylation of hydroxyamphetamine in vivo is accomplished by the same enzyme which converts dopamine to noradrenaline. Glycine conjugation of benzoic acid. The glycine conjugation pathway consists of two steps. CoA ligases and requires energy in the form of ATP. In addition to the factors listed in the boxes, the levels of ATP, CoASH, and glycine may influence the overall rate of the glycine conjugation pathway. Relationship to hypertension and sympathetic activity'. The percent of the drug hydroxylated to hydroxynorephedrine was comparable in all subjects 6. In species where aromatic hydroxylation of amphetamine is the major metabolic pathway, p -hydroxyamphetamine POH and p -hydroxynorephedrine PHN may contribute to the pharmacological profile of the parent drug. Following systemic administration of amphetamine to rats, POH has been found in urine and in plasma. Retrieved from ' https: Amphetamine Ketones Phenyl compounds Benzyl compounds. Views Read Edit View history. This page was last edited on 5 October , at By using this site, you agree to the Terms of Use and Privacy Policy. Other names Benzyl methyl ketone; Methyl benzyl ketone; Phenylpropanone.

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